Cutaneous Capillary Changes In Lupus Erythematosus

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Digital Ulcers as an Initial Manifestation of Systemic Lupus

systemic lupus erythematosus (SLE) and never present as an initial manifestation of disease. In this case re-port DUs appear as the initial manifestation of SLE in a young woman with a capillaroscopic scleroderma pattern and elevated systolic pulmonary arterial pressure.

Cutaneous Manifestations of Rheumatologic Disease

Apr 01, 2014 Lupus Erythematosus Acute Cutaneous Lupus Erythematosus Malar rash Nail fold capillary changes Shawl-like rash

ميحرلا نمحرلا الله مسب

Classification of cutaneous LE spectrum Chronic cutaneous LE (DLE) I) Well defined scarring discoid lesions -ve serology More in females (2:1) No systemic lesions 1. Localized 2.Generalized 3.Hypertrophic 4.Lupus profundus 5.Erosive palmoplantar

Ocular involvement in cutaneous connective tissue disease

lupus erythematosus.3 Lesions of acute cutaneous lupus erythematosus include a transient photo-distributed eruption, malar erythema, and inflammatory discoid lesions. Subacute lupus erythematosus has photo-distributed annular or papulosquamous nonscarring plaques. Lastly, chronic cuta-neous lupus erythematosus encompasses discoid lupus and

Herbal medication triggering lupus nephritis - a case report

sitis, cutaneous, or hematologic involvement. This by itself does not fulfill the usual Systemic Lupus International Collaborating Clinics Classification Criteria for Systemic Lupus Erythematosus (SLICC) [8]criteriaforthediagno-sis of SLE, however the positive renal biopsy showing evi-dence of class V lupus nephritis (LN) is sufficient. The

Systemic Lupus Erythematosus Choroidopathy

Systemic Lupus Erythematosus (SLE) Systemic lupus erythematosus (SLE) is a chronic, systemic, immunologically mediated disease of unknown etiology. Production of a number of pathogenic autoantibodies and immune complexes and an inability to suppress or clear them are the underlying abnormalities in SLE. The revised 11

Cutaneous manifestations in Moyamoya angiopathy: A review

mentioning the cutaneous association in MA and published between 1994 and October 2020. Conclusion: The present review summarizes the cutaneous associations as well as the coincidental dermatological findings seen in MA patients. Those include changes in the epidermis, dermis, or skin appendages for example café-au-lait spots, hypomelanosis of

Posterior Reversible Encephalopathy Syndrome in Systemic

systemic lupus erythematosus: four new cases and review of the literature. Lupus 17(2):139-147. 17. Gatla N, Annapureddy N, Sequeira W, Jolly M (2013) Posterior reversible encephalopathy syndrome in systemic lupus erythematosus. J Clin Rheumatol 19(6): 334-340. This work is licensed under Creative Commons Attribution 4.0 License

Ruxolitinib Attenuates Cutaneous Lupus Development in a Mouse

Mar 19, 2015 cutaneous manifestations at some point in their disease course, and an addi-tional population of patients exists who experience cutaneous lupus but do not meet the criteria for SLE. Discoid lupus erythematosus (DLE), a common lupus-specific skin manifestation, is often a source of disfigurement and scarring alopecia. Currently, there are no

NAILFOLD CAPILLARY MICROSCOPY IN MIXED CONNECTIVE TISSUE DISEASE

* MCTD = mixed connective tissue disease; SLE = systemic lupus erythematosus; SD scleroder- ma. t NS = not significant. susestive of SD displayed all or some of the following morphologic changes: enlargement of capillary loops, loss of capillaries, disruption of the orderly appearance of the

Diseases Of The Skin: Management Of Cutaneous Lupus Erythematosus

skin appendages. There is capillary dilatation, but otherwise gross vascular changes are unusual. Lupus Erythematosus Profundus (Kapo si-Ir gang).?This is a rare variety in which epidermal changes are usually absent. Histological diagnosis is difficult, but often there is a necrobiotic zone deep in the dermis surrounded by a non-specific inflam

BLIND EVALUATION THE DIAGNOSTIC SPECIFICITY OF NAILFOLD

An attempt to compare the degree of capillary changes with the extent of cutaneous disease failed to show a correlation. Of the 5 patients with only modest capillary changes, 3 were in advanced stages of their cu- taneous disease. Conversely, 3 patients with advanced capillary changes of scleroderma were in the early

Pathology of the Cutaneous Vasculitides: A Comprehensive Review

be a manifestation of connective tissue diseases such as systemic lupus erythematosus or Sjögren s syndrome or be associated with viral infections, serum sickness, drug reactions, and exercise (Carlson & Chen, 2006). Cutaneous findings which help to distinguish UV from chronic urticaria include burning,

Pattern of Nailfold Capillaroscopy in Patients With Systemic

Conclusion: The results of our study showed that capillary changes were very common in patients with SLE, which seem to associate with disease activity and RP condition. Keywords: Nailfold capillaroscopy, Raynaud s phenomenon, systemic lupus erythematosus. Systemic lupus erythematosus (SLE) is considered a multi-factorial autoimmune disease,

Acquired poikiloderma: Proposed classification and diagnostic

lupus erythematosus. Cases of poikilodermatous subacute cutaneous lupus erythematosus are rarely reported.1 In one case report from Bulgaria, the patient developed poikilodermatous subacute cutaneous lupus eryth-ematosus after an episode of sunburn, suggesting a role for ultraviolet radiation in the development of this poikiloderma.20

D e rm a t o my o s i t i s - The Lancet

from subacute cutaneous lupus erythematosus (SCLE). The lesions of dermatomyositis differ slightly in their distribution, occurring more over bony prominences, and they are frequently accompanied by severe pruritus. The lesions of lupus erythematosus, however, generally occur between the knuckles and seldom have accompanying symptoms.

APortable Digital Microphotography Unit for Rapid

visible capillary abnormalities in Raynaud s disease/ Raynaud s phenomenon and scleroderma/systemic sclerosis (SSc), a similar association exists in dermatomyositis (DM) and to a lesser extent in systemic lupus erythematosus (SLE). It has been the author s experience as well as that of others2 that nailfold capillary changes are as

RHEUMATOLOGY REVIEW AND UPDATE

SYSTEMIC LUPUS ERYTHEMATOSUS & RELATED DISORDERS Systemic Lupus Erythematosus (SLE) §Chronic inflammatory disease §Immunologic abnormalities §Presence of autoantibodies §Can affect any organ system §Women > men prevalence SLE Classification Criteria 1.Malar rash 2.Discoid rash 3.Photosensitivity 4.Oral ulcers 5.Arthritis 6.Serositis 7

The Role of Dendritic Cells in Cutaneous Lupus Erythematosus

DDCs are located in the papillary dermis predominantly around the capillary vessels (Teunissen et al.1997).In lesional dermis of LE,DDCs can be present in higher num-bers than in perilesional dermis or normal skin (Mori et al. 1994). The Role of Dendritic Cells in Cutaneous Lupus Erythematosus 287

Review of the cutaneous manifestations of autoimmune

Cutaneous lupus erythematosus can be categorized into three major forms which are described as acute, subacute CLE (SCLE) and chronic cutaneous lupus[21]. Within the chronic category, several subtypes are included: discoid lupus erythematosus (DLE), lupus erythematosus tumidus (tumid lupus), lupus panniculitis, and chilblain lupus erythematosus.

Capillaroscopic observations rheumatic diseases*

rheological and morphological cutaneous capillary changes observed in rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), localized sclero-derma (LS), systemic lupus erythematosus (SLE), psoriatic arthritis, anddermatomyositis. Since a review of the literature has shown the needfor amoreuniform terminology, an attempt is

Familial Chilblain Lupus A Monogenic Form of Cutaneous

capillary microscopy showed no patho-logical findings. Although a skin biopsy was not performed at that time, the diag-nosis of cutaneous lupus erythematosus was suspected. Under stringent cold pro-tection and skin care with urea-contain-ing ointments, the patient experienced improvement of skin symptoms during

A Physician s Guide to Myositis

connective tissue diseases, such as systemic lupus erythematosus, scleroderma, Sjögren s disease, or mixed connective tissue disease. The most significant distinguishing feature of DM one that has a significant negative impact on patients quality of life is the presence of cutaneous involvement. Skin changes can precede, coincide

An update in the diagnosis and management of juvenile

and eyelid capillary telangiectasia [38]. Patients with eyelid rash often also have a facial rash that may mimic the malar rash seen in systemic lupus erythematosus. Gottron s papules are papulo-squamous areas of skin with a red appearance and are especially common over the extensor surfaces of the proximal interphalangeal, meta-

EDITORIAL Kidney disease in lupus is not always lupus nephritis

malities in patients with lupus erythematosus (LE). LE can manifest as cutaneous LE or as a systemic disorder (systemic lupus erythematosus, or SLE) [2]. In patients with LE, renal abnormalities, such as elevated serum creatinine levels or urinary abnormalities, require further diagnostic work-up because they may indicate renal

Patterns of finger capillary abnormalities in connective

punched-out lesions in systemic lupus erythematosus. Skin lesions are prominent features of rheu- matic or connective tissue diseases. A variety of clinically recognizable cutaneous changes have been described, most of which include altera- tions at the microcirculatory level (I, 2). Many investigators have observed these changes mi-

r eV ieW Vascular manifestations of systemic lupus erythematosis

It has to be stressed that cutaneous lupus vasculopathy is the most common manifestation of SLE, and is reported in 94% of patients with lupus vasculitis.19,20 Mild forms are characterised by purpura, urticaria lesions or bullous lesions of extremities, and livedo reticularis on the trunk. It has been demonstrated that internal organ vessels are

Remission Achieved with Tacrolimus in a Patient with ISN-RPS

Systemic Lupus Erythematosus (SLE) is a devastating disease that can target various organ systems including the nervous system, heart, lungs, hematopoietic system, and kidneys.3 Variation in the disease of lupus range from cutaneous-only manifestations to severe life threatening diseasesuch as lupus -

Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema

initial manifestation of chronic cutaneous lupus erythematosus. Pan Afr Med J 2012;12:57. 10. Arrico L, Abbouda A, Abicca I, Malagola R. Ocular complications in cutaneous lupus erythematosus: A systematic review with a meta-analysis of reported cases. J Ophthalmol 2015;2015:254260.

DERMATOLOGIC THERAPY Autoimmune disorders: nail signs

Skin changes on the fingers can include petechiae (FIG. 17) as well as psoriasiform lesions (FIG. 18). Leukoderma can also occur, secondary to scleroderma skin changes (FIG. 25). Differential diagnosis of scleroderma nail and periungual pathology Nail fold capillaroscopy of a patient with systemic lupus erythematosus (lupus) reveals a marked

aspects of skin disease in lupus erythematosus

Systemic lupus erythematosus Up to 1872 lupus erythematosus had been considered only as a cutaneous disease. It was Kaposi, son-in-law of Hebra, who in 187214 noted that some patients had severe constitutional symptoms and might die of the disease. Later in 18755 he divided lupus erythematosus into two types: a discoid form consisting of large

Capillaroscopy findings in lupus erythematosus Achados

lupus erythematosus (37 with chronic cutaneous lupus erythematosus and 33 with systemic lupus erythemato- sus) were studied by the technique of capillary microscopy and compared to 32 controls. R ESULTS - The presen-

A subset of systemic sclerosis but not of systemic lupus

such as systemic lupus erythematosus (SLE) and SSc (2, 3). Anti-Ku antibodies are usually asso-ciated with Raynaud s phenomenon, arthritis and myositis, independently from the underlying autoimmune dis-ease (2, 4). Within SSc, anti-Ku are found in about 2 5% of cases (2,5), frequently with a limited cutaneous ex -

Papulonodular mucinosis, Guillain-Barré syndrome and

uncommon changes, is essential for diagnosis and effective management of patients. Case presentation: A 26-year-old Chinese man with SLE initially manifested cutaneous papulonodular mucinosis and developed acute Guillain-Barré syndrome and class V lupus nephritis 2 years later.

Diagnosis and treatment of cutaneous leukocytoclastic vasculitis

Gota Calabree Diagnosis & treatment of cutaneous leukocytoclastic vasculitisREVIEW surrounding tissue [8]. The diagnosis of LCV can be made with certainty if the first two are present (Figure 3) [4]. Thrombi in the lumina of blood vessels can be detected in patients with severe lesions [10]. The histologic changes in LCV evolve and

Criteria for the Classification of Early Systemic Sclerosis

requirement that the patient be both capillary and serology positive (a serology selective for SSc). Two conditions, dermatomyositis and polyarteritis nodosa, can be associated with scleroderma-like nailfold capillary abnormalities and RP. The cutaneous features of these 2 diseases distinguish them from SSc10. It is likely that the experienced

Livedoid vasculopathy current aspects of diagnosis and

lupus erythematosus as well as in tumors. However, these changes develop as a secondary phenomenon [7, 8]. Histology Histologically, characteristically capillary vessels in the upper and middle dermis are occluded by fi brin thrombi as well as fi brinoid degeneration of the vessel walls in the sense of a vasculopathy.

Pulmonary Changes Occurring in Disseminated Lupus Erythematosus

changes as seen on roentgenologic examination of their patients with disseminated lupus erythematosus. Clinically, pleuropulmonary and cardiac disturbances are frequently encounteredindisseminated lupus erythematosus, becoming more prevalent toward the terminal stages of the disease. In the presence of such dis­