Morphological Changes In The Golgi Complex Correlate With Actin Cytoskeleton Rearrangements

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goes a series of morphological changes called evagination, ever-sion and elongation, during which the wing blade pushes out of the imaginal disc. These processes are dependent upon mechani - cal forces and cell rearrangements as the tissue organizes itself into the structures of the adult thorax and wing.23 Later in pupal


at the centrioles inversely correlate with neuronal cilia length, and mutations that disrupt Fbxo41 targeting or assembly into SCF-complexes also disturb its function in cilia disassembly. Fbxo41 promotes cilia disassembly through Aurora A kinase activation and requires rearrangements of the actin-cytoskeleton.

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function, BBS proteins play an essential role in actin cytoskeleton rearrangements, transcrip-tional regulation, and endosomal trafficking [16 18]. An area of growing interest is the molecular role of BBS proteins in cognition. The majority of individuals with BBS experience developmental disabilities ranging from mild cognitive

CELL BIOLOGY Copyright © 2020 Actin modulates shape and

However, the orchestration of morphological changes needs pauses and shape stabilization processes that are often neglected (1). Moreover, experiments on living cells show that the actin cyto-skeleton is associated with tubular membrane intermediates. But how actin is involved in tube fate remains an open question (, 7). An at6 -

2006 The Authors 308 323 Blackwell Munksgaard Vaccinia Virus

complex way wtVV interacts with the host cell to co-ordinate the distinct steps of its life cycle, is known to lead to pronounced changes in cell morphology, collec-tively called cytopathic effect (21). Changes in cell shape and size are likely correlated with rearrangements of the host cytoskeleton, known to occur during wtVV infection.


Amann, K. J. and Pollard, T. D., 2001, The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments: Nature Cell Biology, 3, 306-310. Apodaca, G., 2001, Endocytic traffic in polarized epithelial cells: role of the actin and

Early events in endothelial flow sensing

or branching, mean FSS is lower and undergoes complex changes in direction during the cardiac cycle, which we collectively term dis-turbed flow These flow patterns in vivo correlate with activation of inflammatory pathways and increased susceptibility to atherosclerosis10 13 (Figure 1a). In vitro, unidirectional high laminar

Aldolase directly interacts with ARNO and modulates cell

Mar 08, 2010 aldolase forms a complex with ARNO/Arf6 and the V-ATPase and that it may contribute to remodeling of the actin cytoskeleton and/or the trafficking and redistribution of V-ATPase-dependent acidic com-partments via a combination of protein-protein interaction and gene expression mechanisms.