Pharmacological Preconditioning In Rabbit Myocardium Is Blocked By Chloride Channel Inhibition

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MECHANISMS OF DELAYED PRECONDITIONING WITH A ADENOSINE

later [6]. Furthermore, inhibition of PKC- translo-cation (activation) by chelerythrine chloride blocked the beneficial effects of late preconditioning. Thus, activation of PKC after preconditioning was iso-form selective and PKC- appears to be the specific PKC isotype responsible for the development of delayed protection [42].

Mitochondrial K ATP Channels

blocked by either administering glibenclamide or 5-HD during the preconditioning stimulus or during the 90-minute hypoxic period. These in vitro data provide evidence that the KATP channel is involved as both a trigger and mediator of IPC or PPC. Perhaps more important are the preliminary findings

ISCHEMIC PRECONDlTlONlNG OF THE

Pharmacological preconditioning by direct activation of angiotensin II ATi and adenosine A1/A3 receptors and by stimulation of PKC was abolished by CI- channel inhibition in both the isolated rabbit ventricular myocyte and buffer-perfused whole heart model. In addition, IK1 channel inhibition blocked the protection

Am J Physiol Heart Circ Physiol 283: H1263 H1269, 2002

this drug is blocked by 5-hydroxydecanoate (5-HD), a selective blocker of the mitoK ATP channel (14). By using our in situ rabbit model of myocardial infarction, for the first time, we demonstrate that sildenafil in-duced both acute and delayed cardioprotective effects, which are dependent on the opening of mitoK ATP chan-nel. MATERIALS AND

Selective Inhibition of Inward Rectifier K + Channels (Kir2.1

Selective Inhibition of Inward Rectifier K Channels (Kir2.1 or Kir2.2) Abolishes Protection by Ischemic Preconditioning in Rabbit Ventricular Cardiomyocytes Roberto J. Diaz,* Carsten Zobel,* Hee Cheol Cho, Michelle Batthish, Alina Hinek, Peter H. Backx, Gregory J. Wilson

THE NUCLEAR FACTOR κB IN THE SURVIVAL SIGNALS OF THE

infarct size. This protection, termed classic preconditioning, appears to be an acute and immediate response lasting not more than a few hours. Soon, however, a variety of preconditioning stimuli were uncovered including hypoxia5, rapid cardiac pacing6, 7 , thermal stress8, stretch9, and various pharmacological agents. Also various endpoints of