Development Of The Kidney Vasculature
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Endoplasmic reticulum stress in the pathogenesis of hypertension
points to ER stress in diverse cardioregulatory systems, including the brain, kidney and vasculature, as central to the development of hypertension. Here, these recent ﬁndings from essential and obesity-related forms of hypertension are highlighted in an integrative manner,
Generate vascularized kidney organoids for studying kidney
surrounding vasculature. Right panel focused on the detail structures of glomerular capillary. Mammalian Kidney Development Mammalian kidney development proceeds through three successive phases, pronephros, mesonephros, and metanephros, reminiscent of the evolution of this organ. In mammals, the
Farnesoid X Receptor Activation Prevents the Development of
Farnesoid X Receptor Activation Prevents the Development of Vascular Calcification in ApoE / Mice With Chronic Kidney Disease Shinobu Miyazaki-Anzai, Moshe Levi, Adelheid Kratzer, Tabitha C. Ting, Linda B. Lewis, Makoto Miyazaki Rationale: Vascular calcification is highly associated with cardiovascular morbidity and mortality, especially in
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Three-dimensional organization of the developing vasculature
Kidney function without an intact vessel system is unthinkable. In this context it is of great interest to know the mechanisms behind the development of the renal vascular system. In contrast to the vascular system, the development of the organ parenchyma of the kidney has been investigated intensively (Saxén 1987). Renal orga-
Vascularized human cortical organoids model cortical
vasculature in the cerebral organoids (vOrganoids). And the vascularized cerebral organoids mimicked the lamination progress and circuitry formation of human cortical development well and sharing similar molecular properties with human foetal prefrontal cortical cells. Finally, we intracerebrally implanted the vOrganoids into
The Study of Nitric Oxide Synthase Expression, Function, and
FUNCTION, AND REGULATION IN THE RENAL VASCULATURE DURING POSTNATAL RENAL DEVELOPMENT Brian Blake Ratliff Old Dominion University / Eastern Virginia Medical School, 2006 Director: Dr. Michael J. Solhaug The newborn kidney is vulnerable to vasomotor acute renal failure (ARF) from adverse perinatal events or complications of prematurity.
Paladin (X99384) Is Expressed in the Vasculature and Shifts
sion during mouse development and human tumor angiogenesis. Paladin is expressed in the vasculature, but is also found in hematopoietic cells and other nonvascular cells. Interestingly, the expression is dynamic and ini-tially detected in developing endothe-lial cells, whereas in adult tissues it is found predominantly in the mural cells of the
Kidney - Introduction
toward the papilla. The distribution of the renal vasculature is uniquely suited to supply more blood to the energy-active cortex. Each area of the kidney contains defined segments of the nephron, the functional unit of the kidney, and portions of the collecting duct system. It is imperative for pathologists to understand the
Reconstitution of the embryonic kidney identifies a donor
kidney identies a donor cell contribution to the renal vasculature upon transplantation Vascular development is limited in the reconstituted kidney organoids in vitro.
Paracrine PDGF-B/PDGF-Rβsignaling controls mesangial cell
morphological stages during their development, referred to as comma -, S - and cup -shaped. In addition to the nephric duct- and metanephrogenic mesenchyme-derived epithelial cell types, a third important component of the metanephrogenic kidney is the vasculature. In the glomerulus, this consists of a
Case Report Bilateral Malrotation and a Congenital Pelvic
and th weeks of intrauterine life, the kidney ascends to the lumber region, along the dorsal aorta. e exact mechanism is unknown. e role of an inductive substance secreted by the kidney is invoked . e second opinion says that the kidney undergoes a pseudoascension caused by the fast development of the caudal extremity of the fetus [ , , ].
Development of vascular renin expression in the kidney
nephric kidney development, renin expression in the renal vasculature begins in larger vessels, shifting to smaller vessels and ﬁnally remain- ing restricted to the terminal portions of afferent arterioles at the
Clinical Appropriateness Guidelines: Arterial Ultrasound
IVC, iliac vasculature and associated bypass grafts Selection of the optimal diagnostic imaging for evaluation of disease of the abdominal aorta, IVC or iliac vasculature should be made within the context of other available modalities (which include CT angiography (CTA), Magnetic
Generation of Human PSC-Derived Kidney Organoids with
Cell Stem Cell Article Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network Jian Hui Low,1,13 Pin Li,1,13 Elaine Guo Yan Chew,1,2,13 Bingrui Zhou,1 Keiichiro Suzuki,3,4 Tian Zhang,1,5
Renin Cells, the Kidney, and Hypertension
Apr 04, 2021 ized kidney functions that maintain homeostasis. Thus, the proper and timely assembly of these nephron-vas-cular units is a crucial morphogenetic event leading to the formation of a functioning kidney necessary for inde-pendent extrauterine life. The mechanisms that govern the development of the kidney vasculature are poorly understood.
Vascular instruction of pancreas development
development and regeneration. Studies of the lung vasculature and its impact on lung morphogenesis provide additional evidence of vascular signaling. Studies driven by the clinical need for therapies to ameliorate lung development in premature infants (Northway et al., 1967) have identified endothelial signals in the lung that appear simultaneously
Kidney Organoids and Tubuloids - MDPI
May 26, 2020 in nephrology. Next, we will discuss renal development, homeostasis, and regeneration, as these processes guide organoid culture. Finally, we will focus on the nature of PSC and ASC-derived kidney organoids and their current and future applications in science and medicine. 2. Kidney Physiology, Development and Regeneration 2.1. Renal Anatomy
Anatomical and Clinical Aspects of Horseshoe Kidney: A Review
applications. The search terms included: horseshoe kidney , kidney fusion , kidney vascular and surgery In total, 41 articles in journals were refreshed. The search was limited to articles in English with no date limit. Finally, 25 references were included in the manuscript. Morphology and topography of horseshoe kidney.
Hemovascular Progenitors in the Kidney Require Sphingosine-1
all the necessary precursors for the development of the kidney vasculature.12 In addition, we observed hematopoietic cells budding from the endothelium in embryonic mouse kidneys growninculture,13 suggesting thatthedeveloping kidney gen-erates its own vessels and blood during early development. Althoughwe recently identiﬁed the earliest
Mammalian Kidney Development: Principles, Progress, and
PROCESSES IN METANEPHRIC KIDNEY DEVELOPMENT The kidney eliminates nitrogenous waste, maintains the volume, composition, and pressure of the blood, and the density of our bones. The workhorse of this complex ma-chine is the nephron: a human kidney comprises 200,000 to 1.8 million of these intricately patterned and functional-
Evaluations of the Renal Cell Carcinoma Model Caki-1 Using a
The growth of RCC Caki-1 growing in mouse kidney is illus-trated in Figures 2c and 2d. Differences between normal and tumor vasculature are clearly evident. Figure 2d shows that the tumor vasculature displays many abnormalities including blind ends, loops, and general undulating variations in ves-sel diameter.
Chapter 18: Acute Kidney Injury in the Elderly
Elderly patients are at higher risk for the development of AKI Specific hemodynamic, metabolic, and molecular changes lead to in-creased susceptibility to injury in the aged kidney Certain causes of AKI are more common in the elderly: postrenal obstructive disease, ischemic ATN, and hemodynamically mediated AKI In: elderly.
The earliest metanephric arteriolar progenitors and their
ing kidney. The mechanisms involved in the development of the kidney vasculature are not well understood, but they are intimately linked to nephrogenesis, the formation of the epi-thelial nephron. Nephrogenesis of the deﬁnitive kidney in mammals occurs by the reciprocal inductive interaction of two
Ablation of the Renal Stroma Defines Its Critical Role in
Development of the mature kidney involves complex interac-tions between the metanephric mesenchyme and the ureteric epithelium [1,2]. Subsequently, much of the focus in the field of kidney development has centered on the interactions between these two critical cell types. However, there is an equally important
Refuting the Hypothesis that Semaphorin‐3f/Neuropilin‐2
requires a complex vasculature that must be assembled accurately during development. Mouse metanephric (permanent) kidney development begins at embryonic day (E) 10.5, when the ureteric bud, the precursor of the collecting duct and ureter, evaginates from the caudal end of the Wolfﬁan/nephric duct in response to glial cell line derived
CD146+ cells are essential for kidney vasculature development
culture successfully depicted the dynamics of kidney vasculature development and the correlation of the process with the CD31D EC network. Depletion of Tie1D or CD31D ECs from embryonic kidneys, with either Tie1Cre-induced diphtheria toxin susceptibility or cell surface marker based sorting in a novel dissociation and reaggregation
Immunologic Effects of the Renin-Angiotensin System
heart, kidney, and vasculature that is at-tributable to Ang II (Figure 1). Accord-ingly, ACE inhibition not only amelio-rates cardiac damage after myocardial infarction and slows the progression of proteinuric kidney disease, but also re-duces circulating and urinary levels of inﬂammatory markers. 5,44 48. Early studies investigating the
Pathophysiologic Mechanisms in Diabetic Kidney Disease: A
levels of vessel dilation, rendering the kidney vasculature more sensi-tive to vasoconstriction mediated by other factors, such as endothelin-1.16 The hemodynamic changes observed in diabetes may predispose DKD patients to acute kidney injury (AKI).17 Indeed, sev-eral studies have shown that diabetes is an independent risk factor for AKI.
The Developing Kidney in Toxicity Tests
effects relatively easy to monitor. In vivo, the developing kidney is a sensitive target for harmful effects of biological, physical and chemical factors (see Monie, 1977). Recently, in vitro techniques have been elaborated to study the development and differentiation of the kidney and its components. These techniques have been de-
Multiple renal vascular variations: A case series
of renal vasculature development and to readily identify their anomalies in order to prevent adverse bleeding effects. With the increasing demand for kidney transplantation, living donor grafts have become major source for maintaining donor pool and successful allograft with multiple arteries has been observed.
Quantitative changes in the canine glomerular vasculature
Kidney International, Vol. 20 (1981), pp. 223 229 Quantitative changes in the canine glomerular vasculature during development: Physiologic implications EUNICE JOHN, DAVID I. GOLDSMITH, and ADRIAN SPITZER Department of Pediatrics, Division of Nephrology, Albert Einstein College of Medicine, Bronx, New York
embryonic kidney development is driven by the branching ureteric bud (UB) that originates from the nephric duct on the 5th week of gestation in humans (embryonic day E10.5 in mice) . Throughout its iterative branching, each UB tip induces nephron progenitors to form nephrons, thus forming the metanephric kidney . UB itself will form
Embryonic Kidney Development, Stem Cells and the Origin of
Feb 23, 2021 and vasculature [19 24]. While the innervation and vascular network formation are es‐ sential features of functional kidney development and recent studies indicate a presence of endothelial precursors in embryonic kidney, these topics are not discussed here (for insights, see [25 33]). Figure 2.
Intussusceptive angiogenesis and expression of Tie receptors
maturation of the vasculature was achieved by intussusceptive pruning and branching remodeling. IA is a type of new blood vessel formation in which a capillary is longitudinally split into two vascular Intussusceptive angiogenesis and expression of Tie receptors during porcine metanephric kidney development
Development of the Renal Arterioles
Development of the Renal Arterioles opment of the kidney vasculature are poorly understood. In this brief review, we discuss the anatomical development, embryological origin, lineage relation-
Role of the T cell in the genesis of angiotensin II induced
relative contributions of the vasculature, kidney, and central nervous system to the development of hypertension. In most cases of human h yper-tension, systemic vascular resistance is increased, and genetically altered mice with increased vascu-lar tone are hypertensive, suggesting that blood vessel constriction is a cause of hypertension ( 7
Aldosterone and the Vasculature: Mechanisms Mediating
heart, vasculature, and brain has raised speculation that aldosterone may directly mediate its detrimen-tal effects in these target organs independent of the regulatory roles of angiotensin II and aldosterone in kidney function and blood pressure (BP).14 Endothelial Dysfunction The vascular endothelium plays a fundamental role
Retroaortic left renal vein developmental and clinical
kidney, is clearly visible. The celiac trunk and dissected edge of the superior mesenteric artery is also seen branching from the abdominal aorta. The left suprarenal and gonadal veins, branches of the left renal vein are indicated. b) Dissection of the right kidney shows the dissected edge of the right renal vein draining into the inferior
Engineering neurovascular organoids with 3D printed
Jan 09, 2021 2 FabLab Leuven, KU Leuven Research & Development Belgium 3 Stem Cell and Developmental Biology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium * email: [email protected] Abstract The generation of tissues and organs requires close interaction with vasculature from the earliest moments of embryonic development.