Generation Of Antigenic Diversity In Plasmodium Falciparum By Structured Rearrangement Of Var Genes During Mitosis

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PhD in mathematical modelling of antigenic variation in malaria.

represents a substantial challenge to malaria eradication strategies. During the intra-erythrocytic phase of the parasite life cycle, P. falciparum presumably escapes the immune system with antigenic variation, mediated at least in part by var genes. Each parasite genome contains about 60 different var genes.

Claessens, A; Hamilton, WL; Kekre, M; Otto, TD; Faizullabhoy

2nd generation 10 3D7 'Parent' I 3D7 3D7 P 1st generation 3D7 1h la 3D7 1b 3D7 water 1m (o)2a 3D7 p 200 3D7 la 1400 0 1000 Clonal dilution 1 3D7 Clonal dilution 2 2nd generation 3D7 (o)2b 10 'Parent' I 1st generation 3D7 lh 3D7 1b 3D7 3.5 2.5 1.5 0.5 3D7 1m water Average 2(-CP) chimeric var duplication 3D7 3D7 1m 3D7 10

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falciparum erythrocyte membrane protein 1 (PfEMP1) family, which are expressed by a gene family known as the var genes [1]. The var genes exhibit extreme levels of diversity, allowing the parasites to repeatedly evade detection from the human immune system and remain in the bloodstream over a period of many years.

How Malaria Parasites Avoid Running Out of Ammo

Understanding the generation of var gene diversity clearly requires closer Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis. PLoS Genet 10

Generation of Antigenic Diversity in Plasmodium falciparumby

Generation of Antigenic Diversity in Plasmodium falciparumby Structured Rearrangement of VarGenes During Mitosis Antoine Claessens1.*, William L. Hamilton1., Mihir Kekre1, Thomas D. Otto1, Adnan Faizullabhoy1, Julian C. Rayner1, Dominic Kwiatkowski1,2

Edinburgh Research Explorer

Antigenic Variation in Plasmodium falciparum Malaria parasites operate antigenic variation systems to avoid antibody recog-nition, thereby inhibiting their host s capacity to clear infections [1]. Plasmodi-um falciparum, the most pathogenic of the human malaria species, bases immune evasion on switching expression of ap-proximately 60 var genes.

Fast-changing genes help malaria to hide in the human body

about the Plasmodium falciparum parasite's (2014) Generation of antigenic diversity in rearrangement of var genes during mitosis. PLOS Genetics. DOI: 10.1371/journal.pgen.1004812

Generation of Antigenic Diversity in Plasmodium falciparum by

eration of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis. PLoS Genetics, Public Library of Science, 2014, 10 (12), pp.e1004812. 10.1371/jour-nal.pgen.1004812. hal-01989273