Mutational Analysis Of The Subgroup A Avian Sarcoma And Leukosis Virus Putative Fusion Peptide Domain

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oleh SG Shome 2001 Dirujuk 17 kali analysis of a G91 deletion mutant indicated that G91 was crucial for the Key Words: membrane fusion; alphavirus; Semliki Forest virus; fusion peptide; the domain of E1 that interacts with the target membrane Mutations in the putative fusion peptide of SFV. (TBE), and on the retrovirus avian leukosis and sarcoma.

Route of Entry-Dependent Blocks to Retroviral Replication

oleh ER Gray 2008 The block to replication caused by the putative factor Lv2 was also analysed. analysis). 3.3.3 Co-localisation of fluorescent ASLV Env pseudotyped virions with alpharetroviruses (avian sarcoma and leucosis virus, ASLV); betaretroviruses (mouse host range, FP - fusion peptide, MSD - membrane spanning domain.

Identification and characterization of two novel syncytin-like

oleh M Funk 2018 identified in other mammalian placentas and their role in trophoblast fusion has integrity, a subset of binucleated placental cells cross the maternal epithelium and migrate peptides and domains between the three canonical proteins in a virus anemia virus, ALV: avian leukosis virus, RSV: Rous sarcoma virus, AMV: 

Genetic Analysis of the Rous Sarcoma Virus Subgroup D env

oleh C BOVA-HILL 1991 Dirujuk 30 kali Subgroup D avian sarcoma and leukosis viruses can penetrate a variety of Sequences derived from the gp85-coding domain within the env gene of by either receptor-mediated endocytosis or direct fusion at (allowing interaction with a putative receptor on mammalian transmembrane protein (the fusion peptide).

A General Model for the Transmembrane Proteins of HIV and Other

virus (MMTV), and Rous sarcoma virus (RSV).11-18 The peptide sequence for influenza Effect of specific amino acid substitutions in the putative fusion peptide of structural the loop domain of the S2 SARS-CoV virus protein with model membranes. Mutational Analysis of the Subgroup A Avian Sarcoma and Leukosis.

Aberrant Cell Growth Induced by Avian Winged Helix Proteins'

oleh BS Freyaldenhoven 1997 Dirujuk 34 kali served DNA binding domain of 101 aa that consists of three a-helices, f3-sheets, and The retroviral oncogene v-qin was isolated from the genome of avian sarcoma virus 31. analyzed by using the Universityof Wisconsin Genetics Computer Group com winged helix domain, as well as putative transcriptional regulation.

Cell-specific targeting of lentiviral vectors mediated by fusion

oleh XY Zhang 2010 Dirujuk 20 kali of the avian sarcoma/leukosis virus subgroup A or B receptors receptors due to the leakiness of the mutations that independent fusion domain derived from VSV-G [28,29] A Western blot analysis of cell culture supernatants It encodes 66 amino acids including the signal peptide for the E2 protein.

Pedro Miguel Baptista de Matos - Repositório da

oleh P Matos 2013 Interaction of HIV-1 fusion inhibitor peptides with membranes 13 however showed strong preference for rigid membrane domains, mimicked by However, mutation of the tryptophan rich region of enfuvirtide at its The Avian Sarcoma and Leukosis Virus (ASLV) is an alpharetrovirus that,.

Amino acid residues Tyr-67, Asn-72, and Asp-73 of - CORE

oleh S Klucking 2004 Dirujuk 19 kali important for subgroup E avian sarcoma and leukosis virus interaction receptor interactions as a model system to study the mech- anism of globulin fusion protein undergo extensive cell death in a ogenicity when putative cellular survival factors are signal peptide, extracellular domain, membrane-spanning domain 

Cellular Determinants of Coronavirus Entry Routes - Loyola

oleh JT Earnest 2017 its hydrophobicity, the fusion peptide will insert into the hydrophobic region of the cell's molecular clock analysis of the HCoV-OC43 S protein suggests the virus I fusion glycoproteins are characterized by their helical fusion domains [1, Melikyan, G.B., et al., Low pH Is Required for Avian Sarcoma and Leukosis Virus.

Retroviral Restriction Factors and Their Viral Targets - MDPI

oleh G Boso 2020 Dirujuk 1 kali HIV: Human Immunodeficiency Virus; MLV: Murine Leukemia Virus; SIV: Simian fusion peptide of the transmembrane domain of env, so virions that A subset of the TRIM family of proteins, including TRIM5, also contains a fourth restriction, since capsid-specific replacement mutations can escape 

Structural and Functional Insights into the Molecular - TSpace

Structures of class I viral fusion proteins revealed that electrostatic 2.1 Summary Summary of retroviral fusion protein mutations. Summary of SARS-CoV S2 HR2 peptide mimics. However, avian sarcoma leukosis virus ASLV is an α-retrovirus that undergoes a Putative Fusion Domain of Ebola Virus Glycoprotein.


Subsequent sequence analysis has revealed that at least three retroviruses have subsequently been divided into three subgroups based on pathogenicity. MA from avian sarcoma leukosis virus (ASLV) and murine leukaemia domains while TM contains the fusion peptide and is required for the process of membrane.

ABSTRACT JIA, BIN. Role of the Cytoplasmic Tail of Equine

oleh B Jia 2004 Dirujuk 4 kali Equine infectious anemia virus (EIAV) is a macrophage-tropic lentivirus of horses. mutations affecting the p6 gag protein on human immunodeficiency virus particle terminal hydrophobic fusion peptide, an extracellular domain, a hydrophobic Pfizer monkey virus (MPMV), Rous sarcoma virus (RSV), feline leukemia 

CAR1, a TNFR Related Protein, Is a Cellular - Cell Press

oleh J Brojatsch 1996 Dirujuk 319 kali by subgroups B and D avian leukosis sarcoma viruses CAR1 bound to a viral Env fusion protein, predicted to contain a signal peptide, an extracellular domain with two putative N-linked glycosylation sites, (B) Northern blot analysis of total RNA from chicken cells that were homozygous for tv-bs3 was performed 

Review Article Retrovirus Entry by Endocytosis -

oleh Y Kubo Dirujuk 34 kali acidification. Ecotropic murine leukemia virus entry requires cathepsin proteases activated by the endosome acidification. CD4- domain of the TM subunit called fusion peptide is exposed In case of avian leukosis virus (ALV) infection, there [35] Y. Kubo and H. Amanuma, Mutational analysis of the R.


oleh N Hussain 2009 Feline leukemia viruses (FeLVs) are pathogenic retroviruses of the domestic cat. 1.3.4 Pseudotyped viruses to study envelope receptor interactions 3.4.6 Fusion of NIH3T3/Receptor cells to MD cells rescues FeLV infection. particular the subgroup C FeLV efficiently infect human hematopoietic stem cells making.

Characterization of a structural intermediate of - HAL-Inria

oleh K Stiasny 2007 Dirujuk 91 kali Viral membrane fusion proceeds through a sequence of steps that are driven by triggered conformational application of different triggers (avian sarcoma and leukosis Abbreviations: D, domain; FP, fusion peptide; TBE, tick-borne encephalitis; TM, the analysis by sucrose density gradient centrifugation.

Avian leukosis virus‐receptor interactions

oleh JAT Young 1998 Dirujuk 9 kali Cellular receptors for subgroups A, B, D and E avian leukosis virus (ALV) have been identified and possess a cytoplasmic death domain and have been shown to induce cell result in exposure of the fusion peptide region of Mutations introduced at A putative murine ecotropic retrovirus receptor gene encodes a.

Characterization of a structural intermediate of flavivirus

oleh K Stiasny 2007 Dirujuk 91 kali Viral membrane fusion proceeds through a sequence of steps that are driven by triggered conformational application of different triggers (avian sarcoma and leukosis Abbreviations: D, domain; FP, fusion peptide; TBE, tick-borne encephalitis; TM, the analysis by sucrose density gradient centrifugation.

Improvement of retroviral vectors for efficient gene transfer

oleh F Šenigl 2009 triggers conformational changes of the envelope that result in fusion of viral and avian sarcoma and leucosis viruses and foamyviruses (see chapter 2.1 defined shortly after the first description of viral subgroup C (Duff and Vogt 1969, terminal part of the molecule (signal peptide and extracellular domain), but lacks the.

Respiratory Syncytial Virus and Coronaviruses - Open

oleh W Surya 2013 Dirujuk 15 kali lication of viruses, their absence results in attenuated or weakened viruses or niscent of the two separate domains reported for the amyloid peptide [137], where tide of the avian leukosis and sarcoma virus subgroup a envelope glycoprotein. Mutational analysis of the putative fusion domain of Ebola virus glycoprotein.

Retroviral RNA Splicing: Implication for Mechanisms of - NCBI

oleh RA Katz 1988 Dirujuk 116 kali provides a powerful genetic method for selection and analysis of mutations that affect The avian sarcoma-leukosis virus RNA leader consists of Fusion with the env splice Since quail cells are resistant to subgroup B virus, little, detection assay to map putative suppressor mutations near the env splice acceptor site.

Potential retroviruses in plants - Iowa State University Digital

oleh DA Wright 2000 Dirujuk 3 kali and has putative transmembrane domains reminiscent of a retroviral env gene. Ellermann and Bang were studying Avian Leukosis Virus (ALV) Temin linked these observations with an RNA/DNA hybridization study that suggested Rous Sarcoma domains may act as the fusion and anchor sites for a TM peptide.

ALK - DiVA portal

oleh D Chand Dirujuk 1 kali (ALK) mutations in Neuroblastoma. Abstract. Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that was first reported as a fusion 

Structure of a Conserved Golgi Complex-targeting Signal in

oleh Y Li 2014 Dirujuk 73 kali extramembrane domains in CoV E proteins is available. 1A), reminiscent of viral internal fusion peptides (40 42). didate internal fusion peptide of the avian leukosis and sarcoma virus subgroup a envelope glycoprotein. Mutational analysis of the putative fusion domain of Ebola virus glycopro- tein.

Viral gene products and replication of the human

leukemia (202,203), and a second T-cell leukemia virus, scriptase (RT)] in virions of Rous sarcoma virus, while, lentivirus subgroup that includes retroviruses, which with the DNA polymerase domain of p66 in heterodimer fusion peptide of HA then is to facilitate the formation of Mutational analysis has shown.

Computational analysis of envelope glycoproteins from

oleh A Pluta 2018 Dirujuk 9 kali highly conserved peptide motifs Background: Bovine leukemia virus (BLV) is a deltaretrovirus infecting bovine B cells in epitopes D D′, E‑E′, CD8+ T‑cell epitopes, neutralizing domain 1 and CD4+ the fusion of viral and cellular membranes necessary for Rous sarcoma virus and Avian Leukosis Virus subgroup.

thesis.pdf - KI Open Archive - Karolinska Institutet

oleh SR Wu 2009 facilitates the analysis of the virus and the spikes in their intact form, free from e.g. staining artifacts. outward rotation of the top domain of the chaperone subunit. Location of a putative receptor binding site and the fusion peptide loop in avian sarcoma and leukosis virus HTLV-1 human T-cell leukemia virus type 1.

The transmembrane proteins contribute to - NATAP

oleh J Denner 2014 Dirujuk 35 kali immunosuppressive (isu) domain of the transmembrane envelope protein of leukemia virus (FeLV) [29], deltaretroviruses such as the carefully analyzed (for review see [34]). C-terminal helical region; FP, fusion peptide; FPPR, fusion avian leukosis virus subgroup J-mediated immunosuppression.

Heterologous Avian System for Quantitative Analysis of

oleh K Stafl 2021 receptor, Syncytin-1 triggers cell-cell fusion and formation of a multinuclear syncytiotrophoblast layer of ASCT2 can be simulated by entry of a chimeric avian leukosis-based virus the cytoplasmic domain of Syncytin-1 to 16 amino acids (10) (Fig. the SU glycoprotein of subgroup A avian leukosis and sarcoma viruses.


oleh IV Justice 2015 Avian leukosis virus (ALV) is a simple retrovirus that infects chicken and integrates subgroup-A (ALV-A) or ALV subgroup-J (ALV-J) during embryogenesis often develop In this thesis, I analyze ALV-induced tumors with high-throughput related viruses, are collectively referred to as the avian sarcoma/leukosis viruses.

Activation and BTN2A2 Are Both Inhibitors of T Cell BTN1A1

Immobilized BTN-Fc fusion proteins, but not MOG-Fc protein, inhibited the rodents with a preparation of the IgV domain of bovine BTN1A1 has subgroup C avian sarcoma and leukosis viruses (20). Detection of BTN2A2 by flow cytometric analysis. Expression of a putative receptor for BTN1A1 and BTN2A2 on.

Virology Journal - ScienceOpen

oleh B Manicassamy 2009 Dirujuk 43 kali GP-mediated viral entry, which is mostly likely due to receptor Detailed mapping analysis strongly suggests that the fusion subunit placed apposed to the transmembrane domain. contains an N-terminal putative fusion peptide followed group-determining region of the subgroup A avian sarcoma.

Structure and membrane interaction of the internal fusion

oleh SF Cheng 2004 Dirujuk 21 kali fusion peptide of avian sarcoma leukosis virus fusion peptide (IFP) fragment of the avian sarcoma and leucosis virus (ASLV) envelope glycoprotein was studied by an array of hydrophobic FP domain to destabilize the cell membrane preceding the supported by a mutational study on ASLV fusion protein in which the 


oleh T Postler 1 Summary 4.2.4 Effect of the Cytoplasmic Domain of gp41 on the Levels of Activated Nuclear Serum from a rabbit inoculated with a peptide corre- membrane and conducts the fusion of viral and target cell membrane (26, 81, 143). ALV, avian leukosis virus (genus Alpharetrovirus); MMTV, mouse mammary tumor 

ProQuest Dissertations - Bibliothèque et Archives Canada

oleh EK Clancy 2009 Dirujuk 1 kali peptide. Supporting this hypothesis, specific point mutations of this gleaned from the study of enveloped viral fusion proteins that mediate a different membrane avian sarcoma and leukosis virus putative fusion peptide domain. J Virol protein effects membrane fusion from a subset of membrane microdomains. J Biol.


oleh I Madu 2010 Summary of effects of S2 mutations on SARS-CoV S fusion activity. 49. Figure 2.8 structural proteins S, E, M, N and a fifth protein HE is only encoded in a subset of internal fusion peptide of avian sarcoma/leukosis virus envelope glycoprotein. S HR1 domain as a putative fusion peptide basedon sequence analysis (6).

Efficient method to optimize antibodies using avian leukosis virus

antibody binding affinity avian leukosis virus polypeptide display and single-domain], antigen-binding affinity, specificity, and valency of the single-chain Fv antibodies and the virus fusion proteins in subgroup A envelope glycoprotein (ranging from an 8-aa peptide to detecting avian leukosis-sarcoma viruses.

Functional analysis of a novel baculovirus envelope fusion

oleh M Westenberg Dirujuk 3 kali Chapter 6 Functional analysis of the putative fusion domain of the putative N-terminal fusion peptide of the SeMNPV F protein it is investigated what the Mutational analysis of the AcMNPV heptad repeat revealed that it was essential at a 1992), Avian sarcoma and leukosis virus Pr95 (Dorner and Coffin, 1986), and the.


oleh TMC BARBOSA Dirujuk 2 kali Reticuloendotheliosis virus (REV) infection is associated with runting, mortality, Members of the avian leukosis sarcoma group (ALSV) are classified as these, myelocytomatosis is frequently caused by avian leukosis virus subgroup J (ALV-J) synthetic peptide homologous to a conserved domain within retroviral 

The Many Mechanisms of Viral Membrane Fusion Proteins

sion protein to fold back upon itself, thereby bringing its fusion peptide and its transmembrane Mutations that prevent (1) globular head domain separation. (Godley et al. The protein used for the analysis contained a mixture of fusion peptide of the avian leukosis and sarcoma virus subgroup A envelope gly- coprotein.


oleh H Wang 2004 Dirujuk 1 kali Mutation of either motif (i.e., PPPY changed to APPY or PTAP changed nucleocapsid domains of the bovine leukemia virus Gag polyprotein Development of a VLP System for Analysis of BLV Assembly and proteins or peptides or may be absent altogether. protein (p19gag) of avian sarcoma and leukemia viruses.

Identification of the Fusion Peptide-Containing - Specsci

oleh X Ou 2016 Dirujuk 58 kali tad repeat domains (called the N-terminal and C-terminal heptad repeats, HR-N virus and the envelope protein (Env) of avian sarcoma leukosis virus (ASLV) mutational, biochemical, and biophysical analyses of this region of the S internal fusion peptide of the avian leukosis and sarcoma virus subgroup A envelope 

Retroviral DNA Integration - ACS Publications - American

oleh P Lesbats 2016 Dirujuk 142 kali ABSTRACT: The integration of a DNA copy of the viral RNA genome into is known today as the avian sarcoma-leukosis virus (ASLV).1,2 abundance of HIV-1 IN mutations with pleiotropic phenotypes common to all retroviral genera: the N-terminal domain For example, a LEDGF/p75-based fusion.

Fusion Peptide Domain Putative Avian Sarcoma and Leukosis

Dirujuk 16 kali All Rights Reserved. Mutational Analysis of the Subgroup A Avian Sarcoma and. Leukosis Virus Putative Fusion Peptide Domain. JOHN W. BALLIET, KRISTIN 

Aromatic and polar residues spanning the candidate fusion

oleh N Cifuentes-Munoz 2011 Dirujuk 37 kali previously predicted fusion peptide of ANDV Gc were substituted and mutant proteins tested in fusion and infection analysis of the candidate internal fusion peptide of the avian leukosis and sarcoma virus subgroup A envelope glycoprotein. Mutational analysis of the putative fusion domain of Ebola virus glycoprotein.

Activation of a Retroviral Membrane Fusion Protein: Soluble

oleh LD Hernandez 1997 Dirujuk 150 kali tional change is exposure of the fusion peptide and con- comitant conversion of Abbreviations used in this paper: ALSV, avian leukosis and sarcoma vi- rus; API, GPI-linked ALSV subgroup A Env glycoprotein; BHA, brome- lain-released domain hydrophobic as measured by a liposome binding assay.

Truncated oncoproteins of retroviruses and hepatitis B virus

oleh J Minarovits 2019 Dirujuk 2 kali The best characterised fusion proteins of acute RNA tumor viruses are listed in. Table 2. The genome of Hardy-Zuckerman 2 feline sarcoma virus (HZ2- sequences coding for the signal peptide located to the Env domain in- Fu-J virus (subgroup J Avian Leukosis Virus-associated acutely transforming.

Identification and Characterization of a Shared TNFR-Related

oleh HB ADKINS 2000 Dirujuk 110 kali Receptor for Subgroup B, D, and E Avian Leukosis Viruses immunoglobulin fusion proteins were bound to this cellular receptor before viral challenge.