Glycemic Control And Bone Metabolism In Postmenopausal Women With Type 2 Diabetes Mellitus

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Good Long-Term Glycemic Compensation Is Associated With

of good bone mineral density in Type 2 Diabetes (T2DM) patients is the fracture risk elevated. It is due to reduced bone quality. To determine the effect of glycemic compensation on bone density and trabecular bone score (TBS) in T2DM. We analyzed a cohort of 105 postmenopausal women with T2DM. For all patients,

o f t l ab r u o siol Journal of Diabetes and Metabolism m

atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab 94: 45-49. 3. Kanazawa I, Yamaguchi T, Tada Y, Yamauchi M, Yano S, et al. (2011) Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes. Bone 48: 270-275. 4.

Lack of relationship between glycemic control and bone

density (BMD) and bone remodeling in patients with type 2 diabetes mellitus. We investigated 42 patients with type 2 diabetes under stable control for at least 1 year, 22 of them with good metabolic control (GMC: mean age = 48.8 ± 1.5 years, 11 females) and 20 with poor metabolic control (PMC: mean age = 50.2 ± 1.2 years, 8 females), and


Insulin resistance and cortical bone geometry CONTEXT: In type 2 diabetes mellitus, fracture risk is increased despite preserved areal bone mineral density. Although this apparent paradox may in part be explained by insulin resistance affecting bone structure and/or material properties, few studies have investigated the association

Diabetes and Bone Fragility - Springer

action and bone metabolism [1]. Therefore, both type 1 (T1D) and type 2 diabetes (T2D) are associated with a higher risk of fractures. Nonetheless, the mechanisms of the effects on bone in T1D and T2D may be different and do not necessarily involve a reduction in bone mineral density (BMD) [2]. Several studies show that BMD is lower among

Relationship between glycemic control and OPG gene

6 to 20 years old. Glycemic control, serum parameters of bone metabolism and BMD were evaluated. T1DM patients showed low BMD, poor glycemic control and decreased total calcium values when compared to controls (p < 0.05). For all the polymorphisms studied, the genotype and allele frequencies

Journal of Diabetes and Metabolism - Longdom

Several investigators have reported higher bone mass in type 2 diabetic patients [13,14]. While, other investigators have reported that individuals with type 2 diabetes had lower bone density relative to nondiabetic control subjects [15-17]. Thus contradictory results were obtained in the bone density in type 2 diabetes.

Does Vertebral Bone Marrow Fat Content Correlate With

markers in postmenopausal women with and without type 2 diabetes mellitus (T2DM). Materials and Methods: Thirteen postmenopausal women with T2DM and 13 age- and body mass index-matched healthy controls were included in this study. All subjects underwent 1H-MRS of L1 L3 to quantify verte-bral bone marrow fat content (FC) and unsaturated lipid

Osteoporosis risk in Type 2 diabetes patients

patients with diabetes. J. Bone Miner. Res. 27(2), 301 308 (2012). 3 Janghorbani M, Van Dam RM, Willett WC, Hu FB. Systematic review of Type 1 and Type 2 diabetes mellitus and risk of fracture. Am. J. Epidemiol. 166(5), 495 505 (2007). 4 Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with Type 1 and Type

Pathophysiology and Management of Type 2 Diabetes Mellitus

Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility QUS parameters and poor glycemic control or peripheral in T2DM postmenopausal women with fragility fractures [21].

Abaloparatide in Postmenopausal Women With Osteoporosis and

Type 2 diabetes mellitus (T2DM) increases fracture risk despite normal or increased BMD. Abaloparatide reduces fracture risk in patients with postmenopausal osteoporosis (PMO); however, its efficacy in women with T2DM is unknown. This post hoc analysis evaluated the efficacy and safety of abaloparatide in patients with T2DM.

CURRICULIM VITAE PERSONAL DAT A: Work Address: Box 3470, 303

osteoporosis in postmenopausal women at high risk for fracture, defined adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. with low bone

Impact of non-insulin dependent diabetes mellitus on bone

mact o noninsulin deendent diabetes mellitus on bone structure biomarkers in ostmenoausal obese omen 219 Coyright: 201 iri et al. Citation: Jiffri EH, Al Dahr MHS. Impact of non-insulin dependent diabetes mellitus on bone structure biomarkers in postmenopausal obese women.

Diabetes & Bone Health A Forgotten Complication

1. Dhaliwal R, Cibula D, Ghosh C,Weinstock RS, Moses AM. Bone quality assessment in type 2 diabetes mellitus. Osteoporos Int 2014;25:1969 73. 2. Leslie WD, Aubry-Rozier B, Lamy O, Hans D. TBS (trabecular bone score) and diabetes-related fracture risk. J Clin Endocrinol Metab 2013;98:602 9.

LifePak Abdulla, M., Behbehani, A., and Dashti, H. Dietary

Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr 1998;17:109-15. Chavance M, Herbeth B, Fournier C, Janot C, Vernhes G. Vitamin status, immunity and infections in an elderly population. Eur.J Clin Nutr 1989;43:827-35. Cheng NZ, Zhu XX, Shi HL et al. Follow-up survey of people in China with type 2 diabetes mellitus consuming supplemental

Redefi ning the role of thiazolidinediones in the management

potential implications for maintaining long-term glycemic control in type 2 diabetes. Altering the natural history of type 2 diabetes TZDs and durable glycemic control Type 2 diabetes is a progressive condition characterized by a combination of two fundamental defects: insulin resistance and impaired β-cell function.

Original article Mechanism of action study to evaluate the

women with type 2 diabetes mellitus: rationale, Serum markers of bone metabolism and indices of glycemic control were assessed within and bone effects in a population of postmenopausal

Type 2 Diabetes Mellitus, Insulin Resistance, and Vitamin D

insulin resistance/insulin secretion, glycemic indices, and complications of type 2 diabetes. Pathophysiologic, bystander, pre-ventive, and treatment roles of vitamin D have all been proposed. In this focused review, we attempt to organize and clarify our current information in this area.

Update - CiteSeerX

Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362:1575-85. [PMID: 20228401] Background: Type 2 diabetes mellitus is a substantial risk factor for cardiovascular complications (5), and blood pres-sure control reduces cardiovascular events in persons with type 2 diabetes mellitus (6, 7). Among the 10

Effect of Antidiabetic Treatment on Bone

with Type 2 diabetes (T2DM) usually have normal or higher than expected BMD values et al. 2016, (Hough Vestergaard 2007, Vestergaard et al. 2009). Research over several decades has supported a primary role for insulin and insulin like growth factor-1 (IGF-1) in bone formation (Cimrmanova et al. 2017).

Association of the roles of advanced glycation end products

teocalcin, which is a marker of bone formation and pro-duced by mature osteoblasts, significantly decreased in pa-tients with diabetes compared to non-diabetic subjects27).We previously demonstrated that serum osteocalcin levels sig-nificantly increased after intensive glycemic control in T2DM, while bone-specific alkaline phosphatase (BAP),

Association between glycosylated hemoglobin A1c and bone

Conclusions: Our study found that bone formation was inhibited in postmenopausal women with T2DM, but bone resorption was not affected, and poor glycemic control was related to lower levels of bone formation, may increase the risk of bone fracture in postmenopausal women with T2DM. Keywords: HbA1c, N-MID osteocalcin, PINP, PTH, β-CTX, 25(oh)D 3

Santa Fe Bone Symposium -

bone disease in CKD. Serum levels are higher in diabetics-could explain the low bone formation seen in diabetics. Serum levels higher in younger patients with fragility fractures (pre-menopausal and visceral fat). GLP 1 agonists reduce serum sclerostin levels- might explain a bone potential anabolic effect of GLP 1 agonists on bone.

Diabetes and Menopause

Postmenopausal type II diabetic women are also at higher risk for cardiovascular disease and osteoporosis. Postmenopausal women experience more type 2 diabetes and cardiovascular diseases than their premenopausal counterparts. After menopause there is an increase in dyslipidemia, especially reduced levels of HDL.

The role of enteric hormone GLP-2 in the response of bone

The role of enteric hormone GLP-2 in the response of bone markers to a mixed meal in postmenopausal women with type 2 diabetes mellitus Laura S Girão Lopes1*, Rubens Prado Schwartz2, Bruno Ferraz-de-Souza3,4, Maria Elizabeth Rossi da Silva1,3, Pedro Henrique Silveira Corrêa4 and Márcia Nery1 Abstract

The Interplay Between Bone and Glucose Metabolism

Type 2 diabetes mellitus (T2DM) is characterized by normal-high bone mineral density (BMD) and increased fracture risk (1, 2). Several bone-derived factors may be altered during perturbation of the glucose metabolism and are reported in Table1. The main mechanisms involved in the

Current Health Sciences Journal Vol. 45, No. 1, 2019 January

osteocalcin in type 2 diabetes [10]. Thus, there is a complex relationship between adipose tissue-bone-glycemic metabolism [10]. The major utility of metabolic syndrome in clinical practice is to predict the risk of developing type 2 diabetes along with the cardiovascular disease risk, especially in the

The Impact of Antiosteoporotic Drugs on Glucose Metabolism

Mar 02, 2021 and of the so-called bone quality. Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with impaired bone quality and increased fracture risk. Patients with T1DM have an overall reduced BMD and multifold increased risk for fractures compared with individuals without diabetes. Low bone turnover with reduced bone formation

Bone mass in Type 1 diabetes mellitus - OAText

Several recent studies suggest that diabetes mellitus is an underlying disease for secondary osteoporosis. Furthermore, the risk of fracture is increased in diabetic patients irrespective of their diabetic clinical type. The objective of this is study was to evaluate the bone mineral mass of children with Type 1 Diabetes Mellitus and

Coumarin Ameliorates Impaired Bone Turnover by Inhibiting the

Jul 15, 2020 Optimal glycemic control and prevention of diabetic complications are therapeutic mainstays to lower fracture risk, although thiazolidinediones enhance fracture risk in postmenopausal women diagnosed with type 2 diabetes [23]. Insulin has an anabolic e ect on bone [23]. However, the fracture risk


computed tomography (pQCT) have revealed that type 2 diabetes is associated with microscopic changes in bone structure and marrow composition. A minimally invasive technique called microindentation, which is performed on the tibia under local anesthesia, revealed that women who have type 2 diabetes have compromised bone strength (Farr et al. 2013).


antioxidant effect has role in prevention of type 2 diabetes. 14 The role of Vitamin D in DM is also suggested by a seasonal variation in glycemic control reported in patients with type 2 diabetes being worse in the winter which may be due to prevalence of hypovitaminosis D as a result of reduced sunlight. 13

MECHANISMS IN ENDOCRINOLOGY Mechanisms and evaluation of bone

Subjects with type 1 diabetes mellitus (T1DM) have decreased bone mineral density and an up to sixfold increase in fracture risk. Yet bone fragility is not commonly regarded as another unique complication of diabetes. Both animals with experimentally induced insulin deficiency syndromes and patients with T1DM have impaired osteoblastic bone

REVIEW ARTICLE PEN CCESS Laboratory diagnosis of pre and post

concentration correlated positively with bone mass, whereas glycemic control, BMI, or duration of diabetes did not correlate with bone mass or urinary N-Telopeptide Crosslinks (NTx) concentration in postmenopausal women with T2DM (24). Serum DHEA-S level seemed to be associated

Diabetes Mellitus-induced Bone Fragility

models showed that diabetes induces bone loss and impaired bone strength with a decreased bone formation rate (25, 26). Furthermore, serum osteocalcin levels were reported to be increased after intensive glycemic control in T2DM, whereas bone-specific alkaline phosphatase (BAP) level was de-creased (27, 28).

Effects of vitamin D-fortified low fat yogurt on glycemic

Type 2 diabetes mellitus Vitamin D fortification Low fat yogurt Glycemic status Inflammation Bone turnover summary Background & aims: Low levels of serum 25-hydroxy vitamin D (25(OH)D) are common in type 2 diabetic patients and cause several complications particularly, in postmenopausal women due to their senile and physiological conditions.

Serum undercarboxylated osteocalcin levels are inversely

are associated with glycemic status and insulin resistance in the general Japanese population. were able to walk without aid from others and lived at home in four cities of Nara Prefecture. We excluded participants with a history of diseases or medications that affect bone metabolism, other than type 2 diabetes mellitus (T2DM).

Serum markers of bone fragility in type-2 diabetes mellitus

Keywords diabetes mellitus, bone fragility, markers of fracture risks Highlights Patients with type 2 diabetes mellitus have significantly higher scores in over-vigilance and inhibition schematic domains. Epidemiological studies do not provide unitary information on the association between

The Impact of Diabetes and Diabetes Medications on Bone Health

(2). Adjustment for diabetes complication-related vari-ables did not attenuate the increased risk of fracture. The Women s Health Initiative Observational Study included 93 000 postmenopausal women, of whom 5285 subjects had T2DM. During 7 years of follow-up, women with diabetes had a significantly higher risk of fracture after


injection, submitted by Novo Nordisk, as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. 11/4/2015 Osteoporosis Drug Development: Moving Forward.