Antileukemic Effect Of Alkyl Phospholipids

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DEPARTMENT OF BIOCHEMISTRY AND MICROBIOLOGY

growth. Cu(TAAB)Cl2 possesses an antileukemic activity which at the dose 10 mg/kg of body weight is not accompanied by side toxic effects on mice. Seventeen synthetic 1-substituted 1,2,4-triazoles exerted a significant effect on the bacteria B. subtilis, S. aureus, E. coli and P. aeruginosa.

Coadministration of Histone Deacetylase Inhibitors and

may represent a novel antileukemic strategy. (Cancer Res 2005; 65(6): 2422-32) Introduction Alkyl-lysophospholipids represent a novel class of antitumor agents that target cell membranes and induce tumor cell apoptosis while sparing their normal counterparts (1, 2). Alkyl-lysophospholi-pids include several clinically relevant compounds including

Formulation, Stability, and Antitumor Activity of 1-ß-D

of 1,2-diacyl (1-8), 1-O-alkyl (ether) (9), and 1-5-alkyl (thioether) phospholipids (10, 11). These conjugates have ara-C substituted for cytidine or both ara-C and ether (or thioether) lipid substituted for cytidine and diacylglyceride in cytidine diphosphate diacylglyceride, a precursor for membrane phos-phatidylinositol and cardiolipin (12).

Purging Murine Leukemic Marrow With Alkyl-Lysophospholipids

CONCISE REPORT 1288 Blood,Vol64.No6(December),1984:pp1288-1291 Purging Murine Leukemic Marrow With Alkyl-Lysophospholipids ByLewis Glasser, Lewis B.Somberg, andWilliam R.Vogler

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Phospholipids and Membranes 1971, 93, 314-326 Structural Characterization of n-Alkyl Thiol Monolayers 47 1249 Kosower, E. M. The Effect of Solvent on Spectra

8.Review article Miltefosine a breakthrough in treatment of

phosphocholine and sn-l-alkyl-2-lyso-glycero-3-phosphocholine acyltransferase. The initating steps in the ether lipid metabolism occur in glycosomes. Miltefosine inhibits this glycosomal alkyl-specific-acyl CoA acyltransferase in a dose dependent manner. 14 Miltefosine also stimulates (in vitro) T cells and