Efficacy Of Intradermal Administration Of Herpes Simplex Virus Subunit Vaccine

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c i nes V aoc a l c n in u o r n aoi Journal of Vaccines

Edward Jenner tested the first vaccine that was aimed at small pox in 1796. Overall, vaccination has been a very successful approach for disease prevention. However, more than two centuries after the first vaccine use, there still remain diseases and conditions that cannot be effectively prevented or treated by vaccination. Unfortunately, the

Microneedle-based intradermal delivery of stabilized dengue virus

titis C,42 polio,43,44 herpes simplex,45,46 human papillomavirus,47,48 rotavirus,49 measles and rubella,50 52 rabies,53 HIV,54,55 Ebola,56 chikun-gunya, and West Nile virus.57 However despite extensive advances in MN-based vaccines, there are limited studies addressing the delivery of LAVs. With the exception of measles and rubella, the

The Journal of Infectious Diseases

Ultrastructural Study of Lesions Induced in Rabbit Cornea by Herpes Simplex Virus Types 1 and 2. J. B. HUDSON, M. J. HOLLENBERG, J. S. WILKIE, and B. J. LEWIS 367 Clinical Significance of Lancefield Groups L-T Streptococci Isolated from Blood and Cerebro-spinal Fluid. CLAIRE V. BROOME, ROBERT C. MOELLERING, JR., and BARBARA K. WATSON 382

One does not fit all: new adjuvants are needed and vaccine

ensures controlled intradermal delivery of the vaccine. It is per-ceived as pain-free and the nanopatches are independent of the cold chain. In one example, nanopatches were used to deliver a herpes simplex virus-2 DNA vaccine directly to the cells in the skin. The method was highly efficient and required only small

DNA Vaccine Delivery-Porter-Final

compared IM delivery of a herpes simplex virus type 2 (HSV-2) DNA vaccine to delivery using a nanopatch of densely packed DNA vaccine coated silicone MN array. After 2 vaccinations of a 1 µg dose of DNA, 50% and 92% of the mice seroconverted by IM and MN delivery respectively. Protection from challenge was

Increase in DNA vaccine efficacy by virosome delivery and co

administration technique, which involves placing drops of liquid on the nares and allowing the mouse to inhale. The level of anaesthesia affects the respiration rate and the efficiency of vaccine delivery, and lightly anesthetised mice may swallow, rather than inhale, an aliquot of the vaccine dose. Pretreatment of the nasal passages with lysopho-

Herpes Simplex Virus Vaccines - JSTOR

Herpes Simplex Virus Vaccines Clinical illness caused by herpes simplex virus (HSV), especially the disability associated with recurrent infections, is a significant health prob-lem that cannot be prevented at present [1]. HSV is transmitted horizontally and therefore is sub-ject to control by the host's immune defense sys-tem.