A Finger On The Pulse Of Wnt Receptor Signaling

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Paracrine Wnt/β-catenin signaling mediates proliferation of

Wnt signaling is a highly conserved cell-to-cell communication mechanism, consisting of a canonical and noncanonical branch. Canonical Wnt signaling is also referred to as the Wnt/β-catenin pathway and is often implicated as a stem cell self-renewal mechanism (9). During development, Wnt/β-catenin signaling is

Developmental Cell, Vol. 7, 885 895, December, 2004

EGF Receptor Signaling Regulates Pulses of Cell Delamination from the Drosophila Ectoderm rhythms and hormone pulses, both of which have peri-odsmeasuredindays(reviewedinRiddiford,1993;Ash-more and Sehgal, 2003). In contrast to vertebrate em-Ve´ronique Brodu,1,2 Philip R. Elstob,1 and Alex P. Gould1,* 1Medical Research Council


4.2.3 The role of WNT in the super-enhancer mediated gene gating of MYC 43 5 DISCUSSIONS 45 5.1 THE ROLE OF NUCLEAR PERIPHERY IN THE REGULATION OF GENE EXPRESSION 45 5.2 MYC AND THE CIRCADIAN CLOCK 45 5.3 ADAPTATION TO THE ENVIRONMENT 46 5.3.1 WNT signaling 46 5.3.2 Circadian entrainment 47 5.3.3 Nucleoporins and the transcriptional memory 47

Ephrin-B2 controls PDGFRb internalization and signaling

receptor (Vieira et al. 1996), but, subsequently, similar findings have been reported for the receptors binding in-sulin growth factor, transforming growth factor b,Wnt,or vascular endothelial growth factor (VEGF) (Chow et al. 1998; Di Guglielmo et al. 2003; Yu et al. 2007; Finger et al. 2008; Lanahan et al. 2010; Sawamiphak et al. 2010; Wang

W J B C World Journal of

In addition to the canonical Smad signaling pathway that directly regulates the transcription of Smad-depen-dent target genes, TGF-β function can also be mediated by Smad-independent pathways including MAPK signal-ing pathways, such as p38 MAPK and c-Jun NH2-termi-nal kinase, phosphatidylinositol 3-kinase/Akt pathway, and Wnt signaling[38].

6. Limb development - ResearchGate

capable to direct the development of ectopic limbs. In addition, Wnt signaling to its receptor Patched 1 (Ptc1) and then the transmembrane protein a 3 h pulse of Shh is enough to form

RESEARCH - Science

A finger on the pulse of young stars Adolescent stars quiver and quake before the onset of nuclear fusion in their cores. Zwintz et al. confirm theoretical predictions that the frequency of the seismic oscillations in a given star is tied to its evolution-ary status (see the Perspective by Stahler and Palla). As the protostar evolves and contracts,

Cdc53/cullin and the essential Hrt1 RING H2 subunit of SCF

todes (Kipreos et al. 1996), signaling via the Wnt and Hedgehog pathways in Drosophila (Jiang and Struhl 1998), and activation of the immunoregulatory protein NF-kB in human cells (Yaron et al. 1998). Although SCF ubiquitin ligases clearly regulate diverse physiological pathways in a variety of eukaryotes, little is known

360 ABSTRACTS / Developmental Biology 306 (2007) 355 368

quire Hedgehog signaling, we are currently testing potential interactions between Six3-related genes and this pathway. We have found that six3b and the Hedgehog mediator smoothened interact genetically to generate subpallial cell fates. We will further test whether Hedgehog signaling acts in parallel or upstream of Six3 to form the subpallium.