Inhibition Of Neural Activity Depletes Orexin From Rat Hypothalamic Slice Culture

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An anti-Parkinson drug ropinirole depletes orexin from rat

(Katsuki and Akaike, 2004). On the other hand, we also found that inhibition of neural activities led to reversible depletion of orexin immunoreactivity from hypothalamic slice culture (Michinaga et al., 2010). These findings suggest that alterations of neuronal excitability in either direction can lead to dysfunction of orexin neurons.