Pharmacokinetics And Pharmacodynamics Of Edrophonium In Elderly Surgical Patients

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Edrophonium as an antagonist of vecuroniumâ induced

of edrophonium. Methods After obtaining the approval of the hospital ethics commit- tee and informed consent, we studied 10 elderly patients (70-82 years old) and 10 younger patients (27-54 years old) ASA 1 or 2, scheduled to undergo elective surgery. They were within 15% of ideal body weight. Patients with

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Stone JG. Pharmacokinetics and pharmacodynamics of rocuronium Org 9426) in elderly surgical patients. Anesth Analg. 1993 ; 77 : 1193-7. Meistelman C, Plaud B, Donati F. Rocuronium Org 9426) neuromuscular blockade at the adductor muscles of the larynx and adductor pollicis in humans. Can J Anaesth. 1992 ; 39 : 665-9.

UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL

et al. 1982). In elderly patients, volumes of distribution and elimination half-lives for PB are unchanged from their values in younger groups, but plasma clearance of PB is decreased (6.7 mL/kg-min) in 71- to 85-year-olds compared to 21- to 51-year-olds (9.5 mL/kg-min) (Stone et al. 1995). K 6. How does the human body biotransform (metabolize) PB?

Review When drug therapy gets old: pharmacokinetics and

When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly Klaus Turnheima,b,* aInstitut fu ¨r Pharmakologie, Universitat Wien, Wahringer Str. 13a, Vienna A-1090, Austria bLudwig Boltzmann Institut fu¨r Altersforschung, Donauspital im Sozialmedizinischem, Zentrum-Ost, Langobarden Str. 122, Wien A-1220, Austria Accepted 6