Effects Of Hypericum Extract On The Expression Of Serotonin Receptors

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Patronat: Polskie Towarzystwo Lekarskie, Komisja Młodych

Abstract: St John's Wort (Hypericum perforatum) has been used to treat anxiety and depression for thou-sands of years. H. perforatumextract inhibits the MAO and the reuptake of serotonin, dopamine and other monoamines, and possibly increases the expression of serotonin receptors. Due to these mechanisms, as shown

Effects of a Rhodiola rosea L. extract on acquisition and

of dopamine and serotonin (Brown et al., 2002; Kelly, 2001). Therefore, we have here determined whether pre-treatment with a hydroalcoholic root extract of R. rosea (RHO) can counter both the acquisition and the expression of tolerance and dependence induced by morphine use in mice. Experimental procedures Animals

Interaction of Plant Extracts with Central Nervous System

In contrast, Salviae milthiorrhizae and Zizphi spinose showed the highest affinity to BDZ and serotonin 5-HT1A receptors, respectively. Generally, each plant extract interacted with at least two receptors and in several cases with as many as four receptors, indicating the large spectrum of action of plant extracts in the CNS.

Herbs for Neurology in Restorative Medicine

effects Epigenetic alteration, for example, Hypericum perforatum modulates similar genetic expressions to a conventional antidepressant Sarris J, Panossian A. Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol. 2011

ReView aRticles Plants and their chemical compounds affecting

polyphenols (i.e. flawonoids) are known to exhibit wide spectrum of beneficial effects on brain functioning and to protect against neurodegenerative processes [1, 2]. it seems that influence on β-amyloid is a promising point of pharmacological action of these plant components, because this protein is a major biological risk factor contributing

The effect of Hypericum perforatum on isolated rat aorta

Hypericum compound has also drawn the attention of scientific researches for more than 50 years. It has been demonstrated in the cell culture studies that the antide-pressant effect of HP itself or its ingredients is not only mediated via serotonin receptor (Muller & Rossol, 1994), RESEARCH ARTICLE

Possible Protective Effect of St John s Wort in Brain Damage

effects, beneficial effects have been demonstrated with the addictive behaviour models 7,8. Besides, SJW is used as an antioxidant and anti-inflammatory agent and for stress reduction, immune system booster, and menopausal symptoms 9. It demonstrates by regulating the activity of neurotransmitters such as serotonin, dopamine,


Hypericum triquetrifolium Turra which inhibited paw swelling induced by 1% carrageenin in rats (8). Another plant with anti-inflammatory activity is Curcuma amada an ethanol extract of rhizome which showed inhibitory activity on various acute phases of inflammation and on the formation of granuloma tissue (9). Some studies in Thailand

St. John s Wort

able Hypericum extract (2700mg/kg LI160).There was a significant down-regulation ofβ-receptors without a change in receptor affinity,an up-regulation of5-HT 1A post synaptic receptors without a change in receptor affinity, and an up-regulation of 5-HT 2 receptors (Müller etal.1997;Teufel-Mayer&Gleitz 1997). 5-HT

Hypericum perforatum chronic treatment affects cognitive

of serotonin reuptake.4 Hypericum also has an effect on various neurotransmitter systems via the up-regulation of brain levels of serotonin, norepinephrine, and dopamine. 5,6 Furthermore, this medicinal plant causes down-regulation of D2 receptors and up-regulation of 5-HT2A and BDZ receptors,7 and can increase the levels of intracellular


receptor expression, resulting in reduction and detoxification of highly estrogenic compounds as well as a reduction in excess estrogen production. RESVERATROL This bioflavonoid found naturally in grapes works as a potent antioxidant that binds to estrogen receptors and helps reduce expression and production of excess estrogen.

St. John sWort: A Success Story

receptor radio-ligand binding studies, crude HP extract showed significant receptor affinity for adenosine, GABA , GABA , serotonin, benzodiazepine, inositol triphosphate (IP ), and MAO-A, B (42). Conversely, synthetic hypericin (95%) (a component of HP extract previously associated with the antidrepressant activity of HP extract) lacked

Natural Vitamin & Protein

® (St. John's Wort) extract bound with high affinity at GABAA, GABAB, adenosine, benzodiazepine, inositol, triphosphate, and MAO-A & MAO-B receptors. This may inhibit uptake of several neurotransmitters, neuropeptides & neurosteroids. May also inhibit 5-hydroxytryptamine (5HT, serotonin) receptor expression resulting


Traditional and alternative medicine J.2 3 IACAPAP Textbook of Child and Adolescent Mental Health Table J.2.1. Summary of common herbal/medicinal complementary and alternative treatments used in developed countries for psychiatric conditions in children and adolescents (Rey et al, 201

Herbal Medicine for Pain Management: Efficacy and Drug

Feb 11, 2021 beneficial effects [9,10]. Hypericin can inhibit serotonin, norepinephrine, and dopamine reuptake, weakly inhibits monoamine oxidases (MAOIs) A and B and the crude extracts have a high affinity for gamma-aminobutyric acid (GABA) receptors. This has led to its role as an anxiolytic, sedative, antidepressant, and analgesic [11].

St. John s Wort Promotes Adipocyte Differentiation and

wort (SJW), or Hypericum perforatum, promotes adipocyte differentiation. SJW, a perennial herb, has been used for the treatment of depression in several countries.18,19) SJW inhib-its the serotonin and noradrenaline reuptake, and one of the active consituent of SJW is believed to be hyperforin.20,21)


GREEN TEA EXTRACT Green tea has long been used traditionally to help increase metabolism, prevent disease and reduce the harmful effects of free radicals from the environment. The active components of green tea extract work to decrease aromatization of estrogen to unfavorable and toxic metabolites. It has

Pereira AnaMaria S et al. Isolation and Identification of

The hydroethanolic extract from leaves of A. polystachya was submitted to ultra-performance liquid chromatography-mass spec-trometry (UPLC-MS), and the chromatogram so obtained is pre - sented in Fig. 1a. The main components of the extract were pu-rified by column chromatography and reversed-phase high-perfor-

Hypericum perforatUln: Nature's mood stabilizer

after administration of 300 mg/kg Hypericum extracts to rats. Other proposed mechanisms involve effects on serotonin. Muller and Rossol53 reported that Hypericum extract inhibits serotonin receptor expression at 50 f.!M (-25 flg/mL) and Perovic and Muller54 reported inhibition of serotonin uptake (IC 50 = 6.2 flg/ml). The concentration required

The Aqueous Crude Extracts of Volume 23: 1-12 The Author(s

is, Hypericum perforatum, with reputed antidepressant proper-ties. Nowadays, Hypericum perforatum is used at clinical level exerting anxiolytic and antidepressant effects in humans,4-6 with probed effects on animal models similar to fluoxetine and other clinically effective antidepressant drugs.7-9 Nonetheless, long-

Update and Critique of Natural Remedies as Antidepressant

wort(hypericum),S-adenosylmethionine(SAMe),andtheomega-3fattyacidseicosa-pentaenoic acid (EPA) and docosahexaenoic acid (DHA). ST JOHN S WORT Hypericum is an extract of the flower of St John s wort (Hypericum perforatum L.) that

St John s wort and imipramine-induced gene expression

take of serotonin, noradrenaline, and dopamine;10 12 it also produces monoamine reinhibition and long-term changes in receptors.10 However, there is con-troversy as to the exact mechanism of action for the antidepressant effects of SJW. It is probable that both hypericin and hyperforin have antidepressant proper-ties.

In Vitro Receptor Binding and Enzyme Inhibition by Hypericum

In Vitro Receptor Binding and Enzyme lnhibition by Hypericum pe, rforatum Extract Pharmacopsychiat. 30 (1997) (Supplement) 111 Other proposed mechanisms involve effects on serotonin.


Comments and adverse effects St John s Wort (Hypericum perforatum) Depression Anxiety ADHD As an extract. Active compounds are thought to be hypericin and/or hyperforin Open label trials have indicated children with (mostly mild) depression improve significantly. More rigorous larger trials showed no significant benefit.

Understanding adaptogenic activity: specificity of the

modulate receptor expression via other mecha-nisms. However, adaptogens exhibit multitarget action and the shared use of a number of different receptors, including receptors for corticosteroid, mineralocorticoid, progestin, estrogen, serotonin (5-HT), N-methyl-d-aspartate, and nicotinic acetylcholine, receptor tyrosine kinases, and many

Eskaloft - OakwayNaturals.com

ST. JOHN S WORT EXTRACT (FLOWER)(HYPERICUM PERFORATUM)(.3% hypericin, 3% hyperforin) acts to enhance mood as well as inhibit norepinephrine reuptake. In this way, St. John s wort supports the mood regulatory effects of both serotonin and norepinephrine neurotransmitters.*

St. John s Wort

funded a three-year, multi-center trial comparing the effects of a standardized extract of SJW and the selective serotonin reuptake inhibitor (SSRI), sertraline (Zoloft ®). Since 1979, there have been more than 35 controlled clinical studies of SJW extracts for the treatment of mild to moderate depression. Several meta-analyses

Appendix A. CAM Substances with Evidence of Hormonal Activity

Estrogen-like effects exerted by an unknown mechanism 1-3 Animal studies suggest it might suppress pituitary secretion of luteinizing hormone (LH) 4 Might also act as a partial agonist at serotonin receptors including 5HT-1A, 5HT-1D, and 5HT-7 receptors5 which may play a role in reducing menopausal symptoms Curcumin Curcuma longa Dyspepsia,

Saint John s wort, an herbal inducer of the cyto- chrome

Saint John s wort (SJW) is a standardized extract of hypericum perforatum L that is used to treat mild to moderate depression in adults and children older than six years of age. The usual adult dosage is 300 mg three times daily. SJW is considered to be a fairly safe drug and is devoid of serious side effects (37). SJW is an inducer of the CYP3A4

Efficacy and safety of St. John's wort for the treatment of

5-hydroxytryptamine-1 A (5HT1 A) and 5HT2 A receptors after prolonged administration of hypericum extracts (2700 mg kg21 LI 160 for 26 weeks) to rats, similar to the expression levels of these receptors by synthetic anti-depressants. These results emphasize the importance of serotonin in the antidepressant action mechanism of hypericum11.


effects are the detailed reasons that lead to backsliding to alcohol use. Withdrawal symptoms generally show up inside 6-24 h of restraint from alcohol [10]. Manifestations incorporate a rise in blood pressure, anxiety, agitation, hyperreflexia, tremors, queasiness or heaving, sleep


identification of neurotransmitter systems and their respective synaptic receptors utilized by potential anxiolytic compounds (Sheehan & Sheehan 2007b). As well, there are other CNS structures, than the well-studied ones mentioned above, that play a role in the expression of anxiety, such as the nucleus accumbens (Lopes et al. 2007).

Medicinal herbs with anti-depressant effects

Hypericum perforatum L. is an herbaceous perennial plant serotonin receptors. It also changes the concentration been stated that the plant extract adjusts the expression

An overview on Hypericum perforatum Linn.

expression of serotonin receptors27. The antidepressant activity of hyperforin is attributed to its inhibition of neuronal uptake of serotonin, norepinephrine and dopamine like many other antidepressants and also inhibits GABA and α-glutamate uptake28. The antidepressant activity of hypericum is not only limited to hypericin

Neonatal Development and Memory of Rat Pups Treated with

Hypericum perforatum L. extract is used as treatment for depression and there are few studies on its safe usage during pregnancy. Objective: The aim of this study was to evaluate the effects of Hypericum perforatum on the neonatal development and memory of Wistar rats offspring treated during this period.