Safety And Tolerability Of Acetazolamide In The Idiopathic Intracranial Hypertension Treatment Trial

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University of Birmingham 11-hydroxysteroid dehydrogenase type

We assessed therapeutic efficacy, safety and tolerability and investigated indicators of in vivo efficacy of the 11b-hydroxysteroid dehydrogenase type 1 inhibitor AZD4017 compared with placebo in idiopathic intracranial hypertension. A multicenter, UK, 16-week phase II randomized, double-blind, placebo-controlled trial of 12-week treatment with

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Exenatide Meets Key Endpoints in IIH Clinical Trial Statistically significant reduction in Intracranial Pressure (ICP, the Primary Endpoint) shown in Idiopathic Intracranial Hypertension (IIH) patients receiving Exenatide at 2.5 hrs, 24 hrs and 12 weeks (range 18.1-20.8% versus study hurdle of >10%)

Acetazolamide for the prophylaxis of migraine in CADASIL: a

Acetazolamide is a drug used for a variety of conditions such as congestive heart failure, some forms of epilepsy, glaucoma, idiopathic intracranial hypertension, but also rare diseases, such as acute mountain sickness [11]. When considering central nervous system effects, acet-azolamide penetrates the blood brain barrier slowly, cau-

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1. MollanSP, et al. Idiopathic intracranial hypertension: consensus guidelines on management (2018) 2. Ball et al., A randomised controlled trial of treatment for IIH (2011), Wall et al, The IIH treatment trial: clinical profileas baseline (2014) 3. Thurtellet al., IIH recognition, treatment and ongoing management (2013) 4.

Assessing the Efficacy and Safety of an 11β-Hydroxysteroid

trials (RCTs) assessing the use of acetazolamide in IIH [5]. The review included the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT), which demonstrated beneficial effects of acetazolamide in IIH patients with mild visual loss [6], and a UK pilot study of acetazolamide [7]. Previous studies have

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1. MollanSP, et al. Idiopathic intracranial hypertension: consensus guidelines on management (2018) 2. Ball et al., A randomised controlled trial of treatment for IIH (2011), Wall et al, The IIH treatment trial: clinical profileas baseline (2014) 3. Thurtellet al., IIH recognition, treatment and ongoing management (2013) 4.

The Risks and Safety of Clopidogrel in Pediatric Arterial

medication for children. However, the risks, tolerability, and side effects of clopidogrel (Plavix) in children with AIS have not been reported. The goals of the current study were to assess the safety and tolerability of clopidogrel treatment. Methods Children 1 month to 18 years of age with AIS, seen from January

Safety and Tolerability of Acetazolamide in the Idiopathic

Although the safety and tolerability of acetazolamide dosing at 1 g/d has been docu-mented (16), there is uncertainty regarding the safety and tolerability of acetazolamide beyond 1 g/d due to the lack of high-level clinical evidence. The recent Idiopathic Intracranial Hypertension Treat-ment Trial (IIHTT) provided the first evidence-based

11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in

inhibitor AZD4017 compared to placebo in idiopathic intracranial hypertension. A multicenter, UK, 16-week phase II randomized, double-blind, placebo-controlled trial of 12-weeks treatment

North American Neuro-Ophthalmology Society 42nd Annual Meeting

1. Wall, M, McDermott, MP, Kieburtz, KD, et al. Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial. JAMA. 2014;1641-1651. 2.

Annals of Clinical Case Reports Case Report

MP, et al. Safety and Tolerability of Acetazolamide in the Idiopathic Intracranial Hypertension Treatment Trial. J Neuroophthalmol. 2016; 36(1):13-9. 4. Maisey DN, Brown RD. Acetazolamide and symptomatic metabolic

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1. MollanSP, et al. Idiopathic intracranial hypertension: consensus guidelines on management (2018); 2. Ball et al., A randomised controlled trial of treatment for IIH (2011), Wall et al, The IIH treatment trial: clinical profile as baseline (2014); 3. Thurtellet al., IIH recognition, treatment and ongoing management (2013); 4.

CURRICULUM VITAE DEBORAH ISA FRIEDMAN, M.D., M.P.H. PERSONAL

Idiopathic Intracranial Hypertension Treatment Trial: Randomized, double-masked, multi-center trial to determine the effectiveness of acetazolamide v. placebo, with supervised diet, in subjects with mild visual loss Amount of Award: $ 6,140,434 (total DCBC grant) Merck, 2010 2011 (co-investigator)