Nasal Nitric Oxide Is Independent Of Nasal Cavity Volume
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Rapid Interferon g dependent Clearance of Inﬂuenza A Virus
l PBS into the nasal cavity under Avertin (1.5 ml/100 g) anesthesia, and titers were thereaf-ter determined via serial dilutions of lung homogenates plated onto MDCK cell monolayers for detection of PFU (15). The limit of assay detection was 2.0 log 10 PFU. Lung Immunocyte Isolation. Leukocytes were isolated as out-
Acetylcholine induces contractile and relaxant effects in
increasing posterior blood volume. At higher concentrations, acetylcholine contracts posterior collecting veins as well, implying diminished blood volume in both venous systems, and consequently nasal decongestion. The induced contraction in posterior collecting veins is nitric oxide-independent, while the induced relaxation is nitric oxide
The Wessex Severe Asthma Cohort Study
4.2 Nasal Lavage Subjects were seated in a forward-flexed position and for each nostril, 2.5ml of 0.9% saline (warmed to 37%) was passed slowly into the nasal cavity using a 10ml syringe and then left to dwell for 10 seconds. The saline was withdrawn into the syringe and collected in a sterile tube kept cool on ice. This process was repeated twice.
Human Endotoxin Administration as an Experimental Model in
Nasal mucosa (25 100 mg each nasal cavity) Vital signs and symptoms No changes in vital signs, minimal symptoms 60 62 Local responses Increased nasal lavage levels of neutrophils, neutrophil elastase, leukotriene B4, IL-8, IL-6, GROa, and histamine 60 62 Systemic responses Increased CRP, no leukocytosis 60 62
Effect of smoking on exhaled nitric oxide and flow
Effect of smoking on exhaled nitric oxide and flow-independent nitric oxide exchange parameters A. Malinovschi*, C. Janson#, , T. Holmkvist*, D. Norba¨ck#,+, P. Merila¨inene and M. Ho¨gman*,#,1 ABSTRACT: It is a well-known fact that smoking is associated with a reduction in exhaled nitric oxide (NO) levels.
HKSH Allergy Centre Develops a Clinical Framework for
He consulted doctors and his CT scan showed extensive bilateral nasal polyps filling his sinuses. He was prescribed nasal and oral steroids, but without improvement. Mr. WONG was referred to HKSH s Allergy Centre and in May 2020, accepted Dr. LEE s recommendation to start dupilumab injection treatment once every two weeks for 3 months.
Exhaled and Nasal Nitric Oxide as a Marker of Pneumonia in
gas. To measure nasal NO levels, air was sampled through a nasal prong introduced z 2 cm from the aperture of each nostril sequen-tially. The nasal opening was then occluded in order to measure nasal NO production at a 200 ml/min sampling flow rate into the apparatus. We expressed NO concentration values averaged from the right and left nostrils.
Frans J.M. Harren
Independent measuring time (sec) nasal cavities: 1 - 30 ppmv QCL-based detection of Nitric Oxide NO 1800 1850 1900 1950 0 5 10 15 20 (atm-1 cm-1)
Nasal nitric oxide as a noninvasive marker in the antibiotic
Humming induced release of nasal nitric oxide for assessment of sinus obstruction in allergic rhinitis. Eur J Clin Invest 2004;34:555-60. 7. Deja M, Busch T, Bachmann S, Riskowski K, Campean V, Wiedmann B, et al. Re-duced nitric oxide in sinus epithelium of patients with radiographic maxillary sinus-itis and sepsis.
CO Role of the bitter taste receptor T2R38 in upper
lipids, and enzymes [24,25]. High levels of nitric oxide synthase are expressed in the cilia and micro-villi of the sinonasal epithelium [49,50], and thus the sinuses are thought to be a major source of airway nitric oxide. The nitric oxide produced by sinonasal-ciliated epithelial cells in vitro was found Gram- negative bacteria T2R38 T2R38
Nasal nitric oxide in man - BMJ
the nasal cavity where it is measured. Eccles et al measured nasal NO levels in patients with a common cold but failed to see Table 1 Nasal nitric oxide (NO):eVects of disease Disease Age Nasal NO Reference Kartagener s syndrome Children 2.5 12 yrs Extremely low 6 Primary ciliary dyskinesia Adults Extremely low 69
FeNO Measured at Fixed Exhalation Flow Rate during Controlled
peaks were excluded, as contamination from the nasal cavity could be assumed. Exhalations with a sudden drop in pressure and/or flow were excluded as this reflected leakage. After at least 1 s of exhalation within the target range it was assumed that the rinse volume had been flushed and the steady state of NO was obtained. The subsequent last
Hand-held nitric oxide sensor NIOX MINO monitoring of
Nitric oxide (NO), a free radical gas, once con- in 1987, by two independent research teams [2,3]. In 1991, Gustafsson and NO has been to aspirate nasal air directly from the nasal cavity
Visualization of gaseous monoxide reception by soluble
CO. Test substances were diluted in sterile PBS and infused in a volume of 1 ml i.v. over ~60 s. At desired times after a bolus injection of a test substance, the chest cavity was opened for infusing the fixative from heart. Tested substances were L- and D-arginine at 70 µmol/kg body weight and Nω-nitro-LL
J Appl Physiol innovative techniques - UC Davis
variable ﬂow rate to characterize nitric oxide exchange dy-namics in the lungs. J Appl Physiol 91: 477 487, 2001. Current techniques to estimate nitric oxide (NO) pro-duction and elimination in the lungs are inherently nonspe-ciﬁc or are cumbersome to perform (multiple-breathing ma-neuvers). We present a new technique capable of estimating
Inhibition of nitric oxide synthase by nasal decongestants
Inhibition of nitric oxide synthase by nasal decongestants. G.J. Westerveld, H-P. Voss, R.M. van der Hee, G.J.N. de Haan-Koelewijn, G.J.M. den Hartog, R.A. Scheeren, A. Bast. #ERS Journals Ltd 2000. ABSTRACT: The nasal decongestants oxymetazoline and xylometazoline are frequently used in the topical treatment of rhinitis and sinusitis. As
Reduced Nasal Nitric Oxide Production in Cystic Fibrosis
[13,15,16] in comparison to healthy control groups. Nasal NO levels are known to be lower in CF patients than in control subjects [10,13,14]. The aim of this study was to quantify NO in exhaled
Tipping Point: Are we There?
Nasal Breathing = Healthy Breathing Cleans, humidifies, warms air Nitric oxide uptake from paranasal sinuses Bacterial killer : reduces inflamation Vasodialator Blood pressure O2 uptake by cells Controls respiratory rate (nasal afferents) Parasympathetic tone : Yoga Heart Rate Variability cardiovascular health
J Neurol Disord 2014, 2:5 eurological Disorders
Sinus Hypoxic Nitric Oxide Theory for Migraine To explain the scientific background of the topic, research findings on pathophysiology of migraine, neurological disorders and para-nasal and nasal Nitric Oxide (sNO)  in human beings as well as animals were reviewed. In this article Sinus Hypoxic Nitric Oxide Theory (SHNOT) is mainly considered.
Gas and dust exposure in underground construction is
smaller nasal cross-sectional area and volume than the references, and more pronounced increases after decongestion (pv0.001). To conclude the exposure in underground construction may cause nasal mucosal swelling and increased levels of exhaled nitric oxide, indicating signs of upper and lower airway inﬂammation. Eur Respir J 2001; 17: 416 421.
cavity might be considered a reservoir for H. pylori.7H. pylorihas been found in nasal polyp, nasal mucosa and maxillary sinus mucosa in some patients with chronic sinusitis.4-6 The role of H. pylori infection in ophthalmic diseases such as chronic ocular inflammation, glaucoma,8 rosacea, and chronic blepharitis9 has been postulated. The
Microbiomics of irrigation with xylitol or Lactococcus lactis
form (Xlear). Use of xylitol improved Sino-Nasal Outcome Test-22 (SNOT-22) scores and increased nasal nitric oxide and inducible nitric oxide synthase significantly compared to saline.6 There is evidence xylitol inhibits growth of several common pathogens of the upper aerodigestive tract7 and may prevent dental caries, although quality of
Nitric Oxide and the Paranasal Sinuses
Nitric Oxide and the Paranasal Sinuses JON O. LUNDBERG* Karolinska Institutet, Department of Physiology and Pharmacology, Stockholm, Sweden ABSTRACT The discovery within the paranasal sinuses for the production of ni-tric oxide (NO) has altered the traditional explanations of sinus physiol-ogy.
Nasal NO: normal values in children age 6 through to 17 years
KEYWORDS: Children, nasal nitric oxide, normal values N itric oxide (NO), a potent biological mediator, was first demonstrated to be present in orally exhaled air by GUSTAFSSON et al. . Two years later ALVING et al.  observed the presence of NO in the human nasal airways, and in the paranasal sinuses, in much higher concentrations compared
RESPIRATORY FAILURE IN CHILDREN: Stabilization & Management
Adequacy of tidal volume (chest rise and abdominal excursion) ¾. Presence of symmetric air movement. ¾. Nasal flaring. ¾. Use of accessory muscles Retractions Head Bobbing. ¾. Grunting or stridor. ¾. Inability to lie down position of comfort! ¾. Changes in I:E ratio. ¾. Mental status: agitation or lethargy
Respiratory Research BioMed Central
contribution from the nasal cavity. A mean value of three breaths (or two if the NO concentrations were identical from the two breaths) was used for statistical analysis. Application of the extended NO analysis The extended NO analysis has previously been described and validated. Using the values of fractional exhaled nitric oxide (FE NO
Physiology Edited for The Physiological Society by
priming pheromone androstenol from the nasal cavity to the brain and hypophysis in anaesthetized gilts PATEL A. & SMITH F. G. Renal haemodynamic effects of B2 receptor agonist bradykinin and B2 receptor antagonist HOE 140 in conscious lambs 811 BEHRENDS M., WALZ M. K., KRIBBEN A., NEUMANN T., HELMCHEN U., PHILIPP T., SCHULZ R. & HEUSCH G.
Upper and Lower Airway Patency Are Associated in Young Children
Decongested nasal volume 1 to 4 cm into the nasal cavity was selected as the primary end point as a measure of irreversible upper airway obstruction based on previous sensitivity analyses. 17 Baseline nasal volume 1 to 4 cm into the nasal cavity was used as the secondary end point. Lower Airway Patency: Maximum FEV 1 was assessed by
Serveur Academique Lausannois SERVAL serval.unil.ch´ Author
Volume: 4 Pages: 365-376 DOI: 10.1080/13543784.2019.1582642 In the absence of a copyright statement, users should assume that standard copyright protection applies, unless the article contains an explicit statement to the contrary. In case of doubt, contact the journal publisher to verify the copyright status of an article.
The effect of exercise on nasal uptake of ozone in healthy
nasal volume or cross-sectional areas (as measured by acoustic rhi-nometry) or endogenous nitric oxide production. However, the per-cent change in ozone uptake after exercise, within an individual, was correlated with both 1) percent change in nasal volume (r 0.70 at 10 l/min) and 2) percent change in the rate of volumetric expansion
Complexity, Temporal Stability, and Clinical Correlates of
tients with PCD have low nasal nitric oxide (nNO) levels, which December 2013 Volume 51 Number 12 Journal of Clinical Microbiology p. 4029 4035 jcm.asm.org 4029
NO CO - The Lancet
exhaled nitric oxide. Lancet1997;349: 1742. 4 Dirnberger E, Lucan H, Eichler HG, Kastner J, Pernerstorfer T, Jilma B. Effects of nitroglycerin and sodium nitroprusside on endexpiratory concentrations of nitric oxide in healthy humans. Life Sci 1998;62: PL103 08. 5 Kharitonov SA, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements
Nasal Nitric Oxide - Buteyko Clinic
the lower airways by being inhaled from the nasal cavity. Reduction in inhaled nasal NO might contribute to the negative effects caused by oral breathing that occur during sleep disorders or as a result of a tracheostomy.1 Nasal Nitric Oxide in Respiratory Airways Diseases Nasal Nitric Oxide in Upper Respiratory Tract Infections
Annotation Pulmonary hypoplasia - BMJ
cavity, fetal breathing movements, fetal lung liquid at posi-tive pressure, and normal amniotic ﬂuid volume are all required for normal lung growth in utero. Underlying abnormalities that may result in pulmonary hypoplasia can therefore be divided into: + space occupying lesions in the chest, such as misplaced
viduals with nasal abnormalities, in which high levels of oxidant load and inflammatory mediators such as nitric oxide (NO) concentration in the airways were revealed (15,-18). This information naturally raises a question as to which respiratory structure or function could be in-volved in this phenomenon. This condition could not be
Respiratory Syncytial Virus Rhinosinusitis in Intensive Care
the nasal cavity predispose to infection . The supine position of the patient contributed with diminished mucociliary clearance and poor drainage of the paranasal sinuses . Rouby et al. observed that after 7 days of nasotracheal intubation and nasogastric tube placement, 95% of ICU patients demonstrated radiological pansinusitis, whereas
Can the Vielight X-Plus be a Therapeutic Intervention for
Viral respiratory infections, such as COVID-19 affects both the upper respiratory tract (nasal cavity, pharynx, larynx) and the lower respiratory tract (trachea, primary bronchi, lungs). The potency of COVID-19 is its ability to migrate to the lung and access the host type II alveolar cells, the most abundant type
Chronic rhinosinusitis pathogenesis
CRS without nasal polyps, or CRS with nasal polyps. (J Allergy Clin Immunol 2015;136:1442-53.) Key words: Chronic rhinosinusitis, nasal polyps, mucociliary clearance, epithelial cells, inﬂammation, microbiome Chronic rhinosinusitis (CRS) is characterized by chronic inﬂammation of the sinonasal mucosa and clinically associated
To Sleep, Perchance to Breathe
sleep apnea, can occur at multiple levels including the nasal cavity, the nasopharynx, and the tongue. A greater negative pressure is required to produce a given airflow volume when narrowing in these areas is present. Dilator muscles provide tone to the pharyngeal muscles to hold the airway open but
Recent advances of laser-spectroscopy-based techniques for
cavity. Nitric oxide The presence of endogenous nitric oxide (NO) in exhaled and ofﬂine measurement of exhaled lower airway and nasal and multipass cell