Sex Differences In The Association Of HIV Infection With Hepatic Steatosis
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4 Rob Goldin - University of Leeds
hepatic progenitor cell activation Activation occurs within 1 week Intermediate hepatocytes were seen after 1 week Extensive activation of hepatic progenitor cells and extensive hepatocyte loss were independent predictors of poor outcome
Relationship Between Metabolic Syndrome, Alanine
Relationship Between Metabolic Syndrome, Alanine Aminotransferase Levels, and Liver Disease Severity in a Multiethnic North American Cohort With Chronic Hepatitis B
Emerging Leaders in Nutrition Science Poster Competition
Acid in Hepatic Steatosis in High Fat Fed Mice and in HepG2 Hepatoma Cells. Undergraduate Student Second Place: 57. Justin Guice, LSU AgCenter. Beneficial Effects of Fermentation of Whole Grains (WG) and Whole Grain Resistant Starch (RS) in Lean Zucker Diabetic Fatty (ZDF) Rats. Energy and Macronutrient Metabolism RIS First Place: 82.
Hepatotoxicity of antiretrovirals: Incidence, mechanisms and
conditions or drugs used in HIV infection, can cause elevations in the levels of liver enzymes and should be ruled out. 4. Incidence and risk factors The reported incidence of severe liver toxicity after initiating HAART ranges from 2 to 18% [10 19]. Differences in the study populations, as well as in the methods used probably account for the
TABLE OF CONTENTS
association with human disease, but epigenomic studies lack a similar reference. To address this need, the NIH Roadmap Epigenomics Consortium generated the largest collection so far of human epigenomes for primary cells and tissues. Here the authors describe the integrative analysis of 111
Effectiveness and safety of sofosbuvir/velpatasvir
Aug 06, 2019 differences were observed between treatment groups with respect to age, sex, HIV co-infection, fibrosis stage, cirrhosis and previous antiviral treatment. Of the patients treated with SOF/VEL±RBV and GLE/PIB, 95.7% and 96.7% reached SVR12, respectively (P=0.7). Of patients with and without cirrhosis, 83.3% and 98.4% reached
Relationship Between Alcohol Use Categories and Noninvasive
hepatitis [14 17], and HIV/viral hepatitis coinfection , and can predict liver-related mortality among HCV-monoinfected [19 21]and HIV/HCV coinfected patients [20,21]. Our objective was to evaluate the association between alcohol use categories and advanced hepatic ﬁbrosis, determined by FIB-
RESEARCH ARTICLE Influence of Hepatitis C Virus and IL28B
genotype 1 has been associated with higher mortality, AIDS in HIV/HCV coinfected, and hepatocellular carcinoma [3 5], whereas HCV genotype 3 has been associated with development of hepatic steatosis, fibrosis and progression to cirrhosis in some, but not all, studies [6 10].
Differences in Pathology, Staging, and Treatment between HIV
ﬁndings, were compared by HIV status. Differences between the groups were assessed using Chi-square tests for categorical data and Wilcoxon rank-sum tests for continuous data. We compared survival following date of HCC diagnosis by diag-nostic modality and between the HIVþ and uninfected cohorts.
Mitochondrial DNA haplogroups inﬂuence AIDS progression
infection for the MACS and SFCC. MACS is a US-based ongoing prospective study of HIV-1 infection in adult (ages 18 70) men who have sex with men (MSM) in Baltimore,Chicago,Pittsburgh, andLosAngelesenrolled between 1984 and 1991 . The SFCC is a prospective study of the natural history of HIVand AIDS conducted 2430 AIDS 2008, Vol 22 No 18
Hyperhomocysteinemia and the MTHFR C677T Polymorphism Promote
cells, thus causing hepatic steatosis in the absence of im- muneresponse. 13,14 Inthetransgenicmousemodel,ithas also been shown that the HCV core protein induces ste-
YCCI Scholar Publications
Heimer R. Hepatitis C virus infection among drug injectors in St Petersburg, Russia: Social and molecular epidemiology of an endemic infection. 2009. Addiction. 104 (11). 1881‐ 1890. PMID: 19712125 YCCI Scholar Publications Page 1 of 122
Among the 3122 patients analyzed, 84.6% were male, 45.1% Black
ation of INSTI with hepatic steatosis (HS) which has been associated with increased atherosclerotic cardiovascular disease (ASCVD) risk in the general population has never been evaluated. We sought to evaluate the prevalence of HS among PLWH on ART, its association with race/ethnicity and INSTI exposure and its association with ASCVD risk.
Association of Noncirrhotic Portal Hypertension in HIV
version, we assessed the date of HIV infection in accordance with a back calculation model . For each case patient, we selected 5 control subjects from the Swiss HIV Cohort Study without viral hepatitis, with a similar date of HIV infection ( ± 6 months), and with a follow-up to at least the date of diagnosis of NCPH in the corre-
Analysis of the CD8+ T cell response against hepatitis C
1998) or human immunodeficiency virus type 1 (HIV-1) (Sanchez-Quijano et al., 1995), male sex and older age at infection (Fig. 1.2). In this highrisk group, cirrhosis can develop within - 20 years or less after infection. In contrary, low risk patients often do not have progressive liver disease until 30 or more years after infection.
Differences in Pathology, Staging, and Treatment Between HIV+
Oct 01, 2019 47 among HIV-infected (HIV+) than uninfected persons. It remains unclear if HCC in the 48 setting of HIV infection is morphologically distinct or more aggressive. 49 50 Methods: We evaluated differences in tumor pathology in a cohort of HIV+ and 51 uninfected patients with microscopically confirmed HCC in the Veterans Aging Cohort
Chronic hepatitis B associated with hepatic steatosis
ysis utilizing age, sex, BMI, cholesterol and HOMA-IR as variables revealed that only HOMA-IR (OR=1.66, 95% CI: 1.0-2.7) was significantly and independently predictive of hepatic steatosis in patients with Chronic hepatitis B (Table 2). Table 2. Multivariate logistic regression analysis for hepatic steatosis in patients with Chronic hepatitis B
Human Immunodeﬁciency Virus and Liver Disease: Conference
HIV can directly (infection) and indirectly (gp120 bind-ing) interact with hepatocytes, stellate cells, and Kuppfer cells. Furthermore, it seems likely that active infection of intrahepatic CD4 cells with HIV also occurs. Details re-garding HIV tropism and speciﬁc adaptations remain to be explored.
Prioritisation and the initiation of HCC surveillance in CHB
May 24, 2020 Association for the Study of Liver (EASL) guidelines to e-Antigen positive chronic infection , underscored the possibility of disease progression and the risk of HCC development during this disease phase.16 The emergence of a subsequent immune response with perturbation in liver enzymes and reduction in HBV DNA,
Natural History of HCV Infection - Core Concepts
infection with HCV genotype 3A: multiple studies have shown that persons infected with genotype 3A have a higher prevalence of hepatic steatosis on liver biopsy, which is associated with greater likelihood of progression to cirrhosis and HCC.[44,45,46,47] Coinfection with HIV
Clinical, biochemical and histological differences between
a similar pattern of steatosis and liver injury, which is termed secondary NAFLD.5, 9 HIV-associated NAFLD is an important cause of secondary NAFLD, which is likely multifactorial, and is linked to HIV-associated lipodystro-phy,10 direct medication effects and metabolic risk factors. Non-alcoholic fatty liver disease is a spectrum of liver
13. Which of the following statements is true? [HIV = human immunodeficiency virus, AIDS = acquired immune deficiency syndrome, CD = cluster of differentiation] A) The middle (chronic) phase of HIV infection is usually brief, lasting less than 8 weeks. B) An HIV-positive patient with a peripheral blood CD4 T-cell count of
Association of Noncirrhotic Portal Hypertension in HIV
were similar duration of HIV infection, absence of viral hepatitis, and follow-up to at least the date of NCPH diagnosis in the respective case. Results. All 15 case patients had endoscopically documented esophageal varices and absence of liver cirrhosis on biopsies; 4 died because of hepatic complications.
Toward the Establishment of a Prediction System for the
abolic factors such as obesity , insulin resistance , hepatic steatosis , low-density lipoprotein (LDL) cholesterol levels [15, 16], and y-glutamyl transpeptidase (y-GTP) levels  have been shown to influence treatment outcome. Baseline virus titer is also an important predictor of treatment outcome [14, 18]. HCV
Non-alcoholic fatty liver disease and childhood obesity
Mar 20, 2020 tiate steatosis from NASH and exclude potentially treatable liver disease. Histologically, NAFLD is characterised by steatosis affecting more than 5% of hepatocytes a definition developed from adult data.17 Steatosis with mild inflammation can progress to NASH, with increasing inflammation, hepatocyte injury and fibrosis.
Clinical characteristics of 15 female Japanese patients with
antiretroviral treatment for HIV infection, viral infection, autoimmune disease, and hematopoietic stem cell transplantation [4,9,10]. PL is often underdiagnosed, and the American Association of Clinical Endocrinologists (AACE) has provided consensus recommendations for the detection of lipodystrophy for clinical practitioners .
Non‐alcoholic liver disease and childhood obesity
steatosis may not be detected. By contrast, MRI estimated hepatic proton density fat fraction (PDFF) allows quantification of steatosis severity. MRI PDFF values show significant correlation with histological steatosis grade and may be more useful than ultrasound in defining early disease[14‐16].
Hepatitis C Infection and the Risk of Non-Liver-Related
Hepatitis C Infection and the Risk of Non-Liver-Related Morbidity and Mortality in HIV-Infected Persons in the Swiss HIV Cohort Study Helen Kovari,1 Andri Rauch,2 Roger Kouyos,1,3 Mathieu Rougemont,4 Matthias Cavassini,5 Patrick Schmid,6 Marcel Stöckle,7 Enos Bernasconi,8 Rainer Weber,1 and Bruno Ledergerber1; for the Swiss HIV Cohort Study
L. M. Puga B. S. Alonso J. A. Benetucci Relationship
[bDNA], Versant HIV-1 RNA 3.0 Assay; Bayer, Tarry-town, NY, USA). Body mass index (BMI, weight/height2) was calculated for all patients. We also recorded age, sex, risk behavior, duration of HIV infection, status of HIV infection (A or B or C) according to the Centers for Diseases Control and Prevention (CDC), duration and type
American Gastroenterological Association Technical Review on
(HIV) infection, advanced histologic grade (ie, necroin-ﬂammatory activity), persistently elevated aminotrans-ferase activity, male sex, older age, ethnicity (in some studies, not others), obesity, hepatic steatosis, immuno-suppression,andcertainHLAhaplotypes.32,54,59,61,63 79 Among patients with chronic hepatitis C and com-
I D S & Clinic o f al Journal of l e a n r u o hcrae AIDS
human immunodeficiency virus (HIV) infection . In addition to improving quality of life and reducing acquired immune deficiency syndrome (AIDS) related deaths [2,3], ART treatment has been recognized to prevent HIV transmission by reducing viral load . However, over time ART has been associated with an increasing
performed. The degree of association between non-normally distributed variables was undertaken using Spearman s non-parametric correlation. The c2 test was used to determine differences in patient distribution for variables such as sex. Differences in the grade of steatosis between subjects were compared using either ManneWhitney or the
THE WOMEN S INTERAGENCY HIV STUDY SECTION 41: FIBROSCAN STUDY
AIM 1: To examine the association of HIV, HCV, the menopausal transition and associated metabolic and inflammatory mediators with liver steatosis and liver fibrosis progression (measured using TE with the CAP assessment) in women with HIV/HCV coinfection, HCV and HIV monoinfection, and neither infection.
virus infection Sponsored document from clinical outcome and
Chronic hepatitis C virus (HCV) infection may lead to cirrhosis and hepatocellular carcinoma (HCC). Prospective cohort studies demonstrate that the majority of viraemic individuals never develop severe hepatic fibrosis [1,2]; factors associated with progressive fibrosis include male sex, obesity and concurrent alcohol misuse .
Beneficial IL28B genotype associated with lower frequency of
patients. Similarly, steatosis was found in 67.4% (89/132) of non-CC patients compared to only 39.6% (19/48; p = 0.001) of CC patients in the Duke cohort. Conclusions:IL28B CC genotype is associated with less pro-nounced disturbances of lipid metabolism, as reﬂected both in serum lipoprotein levels and hepatic steatosis, in HCV infection.
Improving Outcomes for Hispanic Patients Undergoing
Latinos with hepatitis C virus (HCV) infection have more rapid progression of fibrosis and decreased response to anti-HCV treatment.1 The high rates of metabolic syndrome, insulin resistance, and hepatic steatosis, as well as genetic differences, may explain the severity of chronic hepatitis C (CHC) in this population.2 10 1.