The Androgen Status Of Aging Male Rats
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Sex differences in vascular physiology and pathophysiology
Mar 07, 2016 male and male mice, activating central ER preserved resting blood pressure by regulating RVLM voltage-gated Ca2 cur-rents (239, 275). In female rats, ER knockdown in the PVN and RVLM using siRNA-ER increased aldosterone-induced hypertension (292), and ER knockdown in female rats under the same conditions showed no effect on blood pressure (292).
Sex hormones, aging and cardiometabolic syndrome
androgen receptor in adipose tissue itself as male mice with both global  and adipose-specific  androgen receptor deficiency exhibit increased weight gain and visceral adipose accumulation. The effects of estrogen on adipose deposition may not be efficacious in the pres-ence of testosterone in males, in contrast to females. In-
PHS 398/2590 (Rev. 06/09), Biographical Sketch Format Page
membrane androgen receptor has different effects on neuronal function and viability in different oxidative stress environments. Oxidative stress is a key feature in aging and many neurodegenerative disorders, such as Parkinson s and Alzheimer s disease. Testosterone can be both protective and damaging, and these effects
News Report of 6th Great Wall Translational Andrology and Urology
chromosome on male fertility, women s sexual health and fertility, urinary issues of Parkinson s disease in a PINK-/- KO rats, as well as the research and clinical application of von Hippel-Lindau (VHL) gene in renal cancer, sexual health contribution to longevity. Free paper presentation A total of 23 young scholars had free paper
Associations between physical activity and the androgenic
syndrome of partial endocrine deficiency may occur in the aging men. Among many lifestyle factors that influence hormonal status is physical activity. Especially interesting are relations between physical activity and the androgenic/estrogenic status of men. The aim of this study was to evaluate age-related changes of serum androgens,
Induction of Dorsolateral Prostate Adenocarcinomas and Other
Groups of 20-25 male Wistar rats (Cpb:WU), nine groups of 4-week-old rats, and nine groups of 8-week-old rats, were given cyproterone acetate (CA) s.c. or by gavage daily for 18 days at a dose of 50 mg/kg/ day. Directly following CA treatment, the rats received 3 daily s.c. injections with testosterone propionate (TP) at a dose of 100 mg/kg/day.
The College at Brockport: State University of New York
changes in the dynamics of steroid metabolism in male rats. Also, few investigations exsist concerning the metabolic clearance rates (M.C.R.) of steroids in blood female rats. This thesis consists of two parts, the first part deals with changes in M.C.R. aging male rats and the second part in pregnant rats.
Formation of Testosterone's 5alpha-Reduced, Versus Aromatized
Aging men can experience decline in gonadal, sexual, cognitive, and affective function. For men, androgen levels begin to rise after puberty and remain high until midlife (Hiort, 2002), when a decade-by-decade decline in endogenous androgen levels occurs (Morley et al,. 1997). On average, this decline, involves a 0.4% reduction in total
Testosterone Influences Spatial Cognition in Older Men
reverse age-related spatial memory deficits in rats and may impair retention in middle-aged rats (Goudsmit, Van de Poll, & Swaab, 1990). In addition, testosterone administration does not increase sexual behavior or receptor binding in older rats to the level of younger rats (Roselli, Thornton, & Chambers, 1993).
A Review of Medicinal Plants with Potential Anti-Benign
gland, induced in adult male rats and photomicrograph of prostate showed extensive shrinkage of glandular tissue. Thus, the extract attenuated hyperplasia and showed to be good prophylaxis against BPH. . Secamone afzelii Secamone afzeliiis a scandent shrub and climber belonging to the familyAsclepiadaceae.
Crucial role of androgen receptor in resistance and endurance
Background: Androgen receptor (AR) has been reported to play vital roles in exercise-induced increase of muscle mass in rats, but needs to be further verified and the mechanism behind remains unclear.
Effect of Bacopa monniera (Linn.) on lipid peroxidation and
7 Jayachandran D K, Status of lipids, lipid peroxidation & antioxidant system with Vitamin C supplementation during aging in rats, J Nutr Biochem, 7 (1996) 270. 8 Lee so, Yeon Chun, Nadiminty N. Trump D L, IpC, Dong Y & Gao A C, Mono-methylated Selenium inhibits growth of LNCaP human prostate cancer xenograft
Cardiovascular and Metabolic Consequences of Testosterone
In contrast, in young male spontaneously hypertensive rats (SHR), we found that endogenous androgens play a role in the regulation of blood pressure since the hypertension was attenuated when the rats were castrated.12 The mechanisms responsible for the elevated blood pressure in young intact male SHR include activation of the renin-angiotensin
Worse progression of COVID‐19 in men: Is testosterone a key
epithelium dramatically decreased with aging more in male rats than female.44 Human ACE 2 locus gene is localized on X chromo - some (Xp22), in an area where genes are reported to escape from X-inactivation and this finding may explain a greater expression of ACE 2 in women than men. 45 However, sex differences in ACE 2 ex-
Endocrine milieu and erectile dysfunction: is oestradiol
2 to aging male symptom scores. It is therefore likely that the androgen deficiency may not be the sole cause for ED in the aging male.26 Literature evidence suggests that oestrogen is as effective as antiandrogen or gonadotropin-releasing hormone analogue in countering the hypersexuality of paraphiliacs27 and E
m a io h a r pharm Clinical Pharmacology & a l a c i n i l
Adult 8 weeks male Wistar rats (240-290 g) were used throughout the experiments and were housed individually in standard polypropylene cages (three rats/cage) under controlled standard conditions of light (12/24 h) and temperature (26 ± 1°C). Food pellets and tap water were provided ad libitum. For experimental purposes
Spotlight on a New Heme Oxygenase Pathway: Testosterone
Aug 07, 2019 The incision was closed, and the rats were allowed to recover. After a 2-week-recovery period, one part of the young and aged castrated animals was administrated cyproterone acetate (Bayer AG, Berlin, Germany; 2.5 mg/kg per day, oral treatment) in order to block the androgen production of the adrenal glands, while the other part of the castrated
Dynamic alteration of serum testosterone with aging: a cross
Keywords: Adult male, Androgen, Serum testosterone in the rodent aging models of Sprague Dawley rats, it was found that aging lead to de- endocrine status
Androgen deprivation therapy and depression in men with
decreased levels of testosterone in gonadectomized male rats led to increased levels of monoamine oxidase A, an enzyme responsible for neurochemical regulation, in the prefrontal cortex. This, in turn, led to decreased levels of the serotonin receptor 5-hydroxytryptamine, which resulted in serotonin dysregulation similar to that seen in
A Critical Analysis of the Role of Testosterone in Erectile
ed erections . In rats, castration is associated with a Table 1 Checklist for the assessment of gonadal status in patients with erectile dysfunction 1. Check for hypoactive sexual desire, reduced frequency of nocturnal erections, or delayed ejaculation: All increase the likelihood to detect hypogonadism. 2.
Current understanding of adult neurogenesis in the mammalian
only in young male rats but not in female or aged male rats, even though androgen receptor expression increases in the hippocampus of both male and female rats after middle age. Aging may result in a loss of reactivity to an-drogen itself. Estrogen also increases hippocampal adult neurogenesis in young and nulliparous female rats but not after
In Utero and Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin
normal prostate development in rats and mice (Theobald et al., 2003). In C57BL/6 mice a single maternal dose (5 lg/kg on gestation day [GD] 13) reduces ventral, dorsolateral, and anterior prostate weight, alters androgen-dependent gene expression, and inhibits ductal morphogenesis and branching.
DOI: 10.1177/ prostate cancer
contractility in spontaneously hypertensive rats. PLoS One 2015, 10: e0127515. 5. Ling M, Wen X, Danyang L, et al. Effect of SARS-CoV-2 infection upon male gonadal function: a single center-based study. medRxiv 2020. 6. Tajar A, Huhtaniemi IT, O Neill TW, et al. Characteristics of androgen deficiency in late-onset hypogonadism: results from
The Aging Sperm: Is the Male Reproductive Capacity Ticking to
semen quality and male fertility status. The present review summarizes, comprehensively, the mechanisms that tend to relate male aging and semen quality with their consequences on semen parameters. Review of English language‑published research articles from 1980, through 2013 was executed using Medline and Medscape databases.
Review Article SexSteroidsandBoneHealthStatusinMen
rats. This could contribute to low bone formation rate, mineralizing rate, and periosteal osteoblast number in these rats . In a study by Yarrow et al., orchidectomized young male rats exhibited reduced trabecular volume, number, and width, increased osteoid surface, and trabecular separation one month after orchidectomy, and the condition was
Free Serum Testosterone Level in Male Rats Treated with
Healthy, adult male Wistar albino rats weighing 200-250g, aged 4-5 months were used in this study. The animals had free access to a standard commercial diet, water and were kept in rooms maintained at 25 ± 1°C. The animals were divided randomly into different groups; each group consisted of six rats. Control groups treated with distilled
Corni Fructus attenuates testosterone-induced benign
Dec 05, 2018 cell nuclear antigen in BPH rats, and this blocking was associated with a decrease in prostate-specific antigen levels in serum and prostate tissue. CONCLUSIONS: These results suggest that CF may weaken the BPH status through the inactivation of at least 5α-reductase and AR activity and may be useful for the clinical treatment of BPH.
Androgen interacts with exercise through the mTOR pathway to
Androgen and exercise induce muscle hypertrophy through mTOR Muscle atrophy, caused by aging, lack of physical activity, and vari- A total of 24 male Sprague-Dawley rats were randomly
Role of Stromal Paracrine Signals in Proliferative Diseases
Apr 02, 2018 growth-stimulating androgens. Moreover, the incidences of proliferative diseases of the aging human prostate, including benign prostatic hyperplasia (BPH) and prostate cancer (PCa), apparently increase with advancing age, despite decreasing androgen levels . The androgen status affects prostatic structure and components. In the absence of
MECHANISMS IN ENDOCRINOLOGY Vitamin D and fertility: a
for fertility (8). Moreover, many adverse aspects of male aging have been attributed to the decrease in testoster-one levels (9) and some evidence suggests an associ-ation of androgen and vitamin D metabolism (10, 11). The focus of this review is the examination of research evidence relating to vitamin D status and
Age-related changes in the expression β in rat Leydig cells
men . Demonstration that declines in androgen lev-els result from specific age-related changes in the male reproductive system and not secondarily from increased disease frequency associated with the aging process, was achieved by analyzing cohorts of healthy men and rodents [2,3]. Using old rats treated with
Hypogonadism Precedes Liver Feminization in Chronic Alcohol
fed male rats and possible consequences of such changes. Rats were fed alcohol-containing or isocaloric diets for 30, 60, and 90 days. In alcohol-fed rats, serum testosterone levels and hepatic activity of 2 androgen-dependent estro-gen metabolizing enzymes were reduced (P F.05) at all times, as was activity of androgen receptor. There was also a
The College at Brockport: State University of New York
This st!dy examined the effects of aging on testicular endocrine fu ,ction and response to gonadotropin stimulation in male rats. Sprague-Dawley rats of 4 and 18 months were used thruugh,uL. Peripheral blood, testicular venous blood and endogeno1u testicular production were quantified for testosterone (fl'), 20 a.:
Ageratum conyzoides L. inhibits 5-alpha- double blind
blood glucose, the Aging Male s Symptom (AMS) Score and sexual function assessed by Derogatis Interview for Sexual Functioning-Self Report (DISF-SR). The effect of A. conyzoides L extract on gene expression of 5-alpha-reductase in human prostate cells was also investigated to elucidate a potential mechanism of action.
Testosterone represses ubiquitin ligases atrogin-1 and Murf-1
groups were compared with intact rats, all subsequent experiments were performed with tissues from intact, age-matched rats as controls. In another set of experiments, adult male Swiss mice, obtained and maintained as described for rats, were randomly assigned to control (N); castrated 3 days (C3), or castrated 3 days before and then treated
Epigenetic status determines germ cell meiotic commitment in
rats as models.6,7 Further, injection of adult female mice with the class I/II histone deacetylase (HDAC) inhibitor, trichostatin-A (TSA), increases primordial follicle numbers, with the greatest effects observed in aging mice that possess a diminished follicle reserve.6 In addition to this body of work, genetic studies have identified
Peptides for Sleep, Improving Telomeres, Libido, Testosterone
aging Besides producing melatonin it produces epithalamin Discovered by researchers in Russia in the 1970 s Dilman VM, Anisimov VN Biull Eksp Biol Med. 1975 Nov;80(11):96-8. Khavinson VK, et al. Exp Pathol (Jena). 1979;17(9):539-45.
Editorial Team - Universitas Udayana
46, XX Infertile Male: A Case Report and Review in Infertility Gito Restiansyah Wasian PDF The Relationship between Nutritional Status and Lifestyle with Risk of Early Menarche among Adolescent Iqlima Dwi Kurnia PDF Evaluation of Antioxidant Efficiency of Nanosized Quercetin: An In Vitro Study Ghassan M. Sulaiman PDF
A double blind, placebo-controlled randomized comparative
7, Aging Male Symptoms (AMS) score≥27, and responding positively to question 1 or 7 or any other three questions of the Androgen Deficiency in the Aging Male (ADAM) questionnaire, were included in the trial. Subjects with neurogenic bladder dysfunction, prostatic cancer, prostatitis, haematuria diabetes or any other