Sperm Distribution And Degradation In The Human Female Reproductive Tract
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The emergence of extracellular vesicles in urology: fertility
evasion of sperm from female reproductive tract comple-ment attack mediated cell lysis (18). Furthermore, studies have also suggested that prostasomechromogranin B is bactericidal and that prostasome fusion with spermato-zoa inhibits immune cell phagocytosis (16,17). Addition-ally, EV impart an antioxidant capacity to sperm, which
Virology Journal BioMed Central
Background: The female reproductive tract is amongst the main routes for Human Immunodeficiency Virus (HIV) transmission. Cervical mucus however is known to protect the female reproductive tract from bacterial invasion and fluid loss and regulates and facilitates sperm transport to the upper reproductive tract.
Silencing of the Hsf gene, the transcriptional A. gambiae
of effects on the female s reproductive physiology including the induction of oogenesis, ovulation and oviposition,1,2 accompanied by a markedly reduced propensity to remate.1,2 Additionally, Acps play a key role in the storage and utilization of sperm and in sperm competition.1,2 Though Acps have been identi-
e n t e r of o r R epr d uc ti v e a n i c e d i OF REACTIVE
regulation of sperm motility within the female reproductive tract. Reactive oxygen species (ROS) play a major role in the pathology of male infertility by modulating sperm function. Seminal plasma is a natural reservoir of antioxidants and protects against ROS toxicity. The goal of this
Cholesterol efflux from sperm: approaches and applications
freshly ejaculated sperm are motile and have fertilizing abil - ity, they are unable to fuse with the oocyte immediately af-ter ejaculation. During their migration through the female reproductive tract, sperm undergo a series of controlled biochemical and membranous changes known as capacita-tion (1). During capacitation, sperm experience a number
Morphological selection of human spermatozoa in vitro
reproductive tract is now generally accepted, but although sperm motility has often been suggested to bethe causal mechanism (for review see Mortimer, 1978), absolute proof does not exist.
mammalian female reproductive system. In the mouse reproductive tract, only CB1 receptor is expressed in the uterus and oviduct (Das et al., 1995; Paria et al., 2001; Wang et al., 2004), whereas both CB1 and CB2 receptors have been found in preimplantation embryos. CB1 receptor mRNA was detected from the 4-cell stage to the blastocyst
The Relationship Between Widespread Pollution Exposure and
Mar 13, 2020 center. To study the biomarkers distribution and oxidative stress in the male reproductive tract, both urine and seminal plasma (SP) were analyzed. Finally, an approach based on a multivariate model accounting for the multiple exposure was applied.
2012 MENTOR SELECTION FORM
characteristics of sperm as they progress through the male reproductive tract, and later, as they travel through the female tract. Morphological changes include differences in subcellular ultramicroscopic and the ability of sperm to swim and fertilize eggs. Participants will assist in the daily care and feeding of the snakes as well as in the
Theseminalacrosin inhibitorClTI1/SPINK2isa fertility
Moreover, bird sperm biology faces a spermatogenesis producing a high number of sperm (billions in the chicken) in a short time (12 days in the chicken), a lack of accessory glands in the male tract, and a post gonadic process in the female tract that is much longer (3 weeks in the chicken, 2 3 months in the turkey) where sperm evolve in highly
Genetic instability and anti-HPV immune response as drivers
type, Sperm cells, Oocyte, Gastrulation, Genomic instability, DNA damage, Viral integration Key points HPVs infect male and female genital tract, the infection is associated with various pathologies including the development of cancer. Replication of HPVs in dividing cells of the female and male genital tract can cause disruption of the cell cycle,
Review Article Molecular Chaperones, Cochaperones, and
reproductive tract and capacitation in female reproductive surface of human sperm and is impaired in idiopathic the distribution pattern of Hsp and Hsp was
Freezing Thawing Procedures Remodel the Proteome of Ram Sperm
Sep 17, 2019 capacitation [14 16]. Therefore, the acquisition of sperm function and their fertilizing ability depend on post-translational modiﬁcations of existing proteins , interaction with proteins present in the male and female reproductive tract , or probably even on the synthesis of new proteins .
mine whether the distribution of protamine 1, the most abundant human protamine, was altered in sperm nuclei during in vitro sperm-oocyte interac- tion through a comparative immunoelectron micro- scopic study of sperm nucleus labeling with an anti- human protamine i monoclonal antibody. MATERIALS AND METHODS
RNA sequencing reveals candidate genes and polymorphisms
sis, the DNA of sperm cells is tightly packed by protamine and results in a condensed chromatin structure . This leaves the DNA protected against degradation during transport through the male and female reproductive tracts until fertilization. Altered sperm chromatin structure is * Correspondence: [email protected]
Hsp90 modulates human sperm capacitation via the Erk1/2 and
Keywords: Sperm capacitation, Hsp90, Erk1/2, P38, MAPK signaling pathway, Phosphorylation Background Spermatozoa that have just been ejaculated cannot fertilize oocytes and must undergo a series of biochem-ical and physiological events in the female reproductive tract to become fertilization competent. This process is known as sperm
Complement:more guard invading pathogens?
the entire female reproductive tract (including the endometrium, cervical epithelium and Fallopian tubes) . This prominent expression of membrane regulators, such as decay accelerating factor (DAF), membrane cofactor protein (MCP), CD59, CR1 (complement receptor-type 1) on all reproductive epithelia as well as on the surfaces of sperm
The effect of an IgA1 protease on immunoglobulins bound to
sperm surface were degraded by gonococcal IgA 1 protease, as judged by both a diminution of im munobead binding and the subsequent ability of such treated sperm to penetrate cervical mucus (Table 2). Protease degradation of IgAl on the sperm surface occurred rapidly and was nearly complete by 30 minutes (Fig. 1). In contrast,
Carnitines and male infertility - Home Page: Reproductive
1988). Within the male genital tract, carnitines are concentrated in the epididymis and spermatozoa. While in ejaculated seminal fluid, most L-carnitine (LC) and acetyl-L-carnitine (ALC) are found in the seminal plasma; very little are found in the spermatozoon itself (Bohmer et al., 1978). L-Carnitine and ALC play a key role in sperm metabolism by
Tuning the oviduct to the anandamide tone
lipase D (NAPE-PLD) and its degradation by fatty acid thisamide hydrolase (FAAH) in mouse embryos and oviducts creates locally an appropriate anandamide tone required for normal receptorsembryo development, oviductal transport, implantation, and pregnancy (see the related article beginning on page 2122).
Physiopathological factors affecting the diagnostic value of
colonic, gastric, hepatic, and prostatic carcinomas. In female reproductive organs, HE4 was detected in endometrial gland, endocervical gland, fallopian tube, and Bartholin s glands, whereas the normal ovarian surface epithelium, corpus luteum, and primary oocytes were negative for immunostain-ing with HE4 antibody .
Reprint of Potential seminal transport of pharmaceuticals to
Human tissue kallikrein-related peptidases are expressed throughout the female reproductive system, including in cervico-vaginal ﬂuid. Kallikrein-related peptidases are localized in the glandular epithelium of the fallopian tubes and endometrium, the cervical mucus-secreting epithelium, and vaginal stratiﬁed squa-mous
Human sperm degradation of zona pellucida proteins
sperm proteases may be involved in human sperm pene-tration of ZP but this process remains unestablished due to the limited access to native human ZP. In the present study, we show evidence that human and mouse ZP were ubiquitinated and that human sperm is able to degrade re-combinant human ZP proteins by a proteolytic-mediated process.
RESEARCH ARTICLE Open Access The battle of the sexes starts
tem exists in the female reproductive tract. Further-more, we propose that this sperm recognition system can modulate the gender selection of the offspring. Our hypothesis challenges two long-held assumptions: 1) on the female side, that the reproductive tract is a passive participant in sperm selection  and 2) on the male
Effect of Bisphenol A on human health and its degradation by
the decline in sperm counts and the increased rates of hormone-related cancers, such as cancers of the breast, testes, and prostate. They are also suspected of causing birth defects of the reproductive tract and other hormone-related effects, such as early puberty in girls. BPA has been detected in urine and serum of pregnant
Immunoglobulin levels and phagocytes in the cervical mucus
respiratory and reproductive tracts. In addition, the continual turnover and transport of the secre-tions together constitute a significant mechanical element of protection. By entrapping and remov-ing microorganisms, the mucus may prevent colonization and invasion of the underlying epithelium. In the female reproductive tract, cervical
2010 Sigma Xi Symposium Abstracts - gustavus.edu
identified Histone 3.3A as having a possible role in female reproduction. We characterized this gene by examining its role in components of female reproduction including: the number of eggs laid, progeny produced, and sperm storage as well as reproductive tract morphology (seminal receptacle length and spermathecae volume).
(MUMS) Reviews in Clinical Medicine
through the female reproductive tract and suc-cessful fertilization. A negative correlation was shown between increase the level of ROS and reduce of sperm concentration, morphology and motility (17, 18). The residual cytoplasm in im-mature spermatozoa contains high level of glu-cose-6-phosphate dehydrogenase (G-6-PDH),
Center for Environmental Genetics Pilot Awards 2012 2020
Gene-Environment Interactions in Female Reproductive Tract Development 2019 Innovator KyoungHyun Kim, PhD DEH A role of environmental toxicant induced IncRNA in pancreatic disease and cancer 2019 Innovator Pheruza Tarapore, PhD DEH An in vitro model to mimic spermatogenesis and spermiogenesis 2019 Innovator Neville Tam, PhD EGMT
Molecular interactions of chlorpyrifos and its environmental
reproductive disorders, including infertility in male and female. Sex hormone‐ binding globulin (SHBG) is a circulatory protein that binds sex steroids and is a poten-
The Clinical Significance of Endocannabinoids in
the female reproductive tract ﬂuids, as well as ovary, has been demonstrated.38 AEA plays an important role in folliculogenesis, preovulatory follicle maturation, oocyte maturation, and ovulation.39 A study conducted on women who had undergone IVF/intracytoplasmic sperm injection-embryo transfer showed that higher
The Drosophila melanogaster Seminal Fluid Protein Acp62F Is a
Acp62F into the mated female s hemolymph, we propose that Acp62F is a candidate for a molecule to contribute to the Acp-dependent decrease in female life span. We propose that Acp62F s protease inhibitor activity exerts positive protective functions in the mated female s reproductive tract but that entry of a
Success and failure in human spermatogenesis as revealed by
Success and failure in human spermatogenesis ment and sperm maintenance during sperm transport within the female reproductive tract continues to accumulate (5,6). conditions affecting the
Causes and consequences of sperm mitochondrial dysfunction
The functionality of sperm mitochondria is also physiologically important during epididymal storage, as well as from ejaculation to movement within the female reproductive tract and in sperm oocyte interactions (Amaral, Lourenco, Marques, & Ramalho-Santos, 2013). The sperm mitochondrion possesses its own genome,
Human aquaporins: Regulators of transcellular water flow
o) Female reproductive tract AQP7, AQP8 and AQP9 in ovaries, and p) Male reproductive system AQP3 and AQP7 in sperm cells. R.E. Day et al. / Biochimica et Biophysica Acta 1840 (2014) 1492 1506 1493
human female reproductive tract has been shown to induce local inﬂammatory changes that are believed to protect against infectious agents introduced during intercourse (Robertson & Seamark 1990, O Leary et al. 2004, Sharkey et al. 2007). Thus, while sperm presents an immunologic challenge, seminal plasma appears to
The role of peptidases in (in) fertility
sperm mobility is necessary an adequate level of enkephalins, and even, that the effect of these peptides depends on their concentration in the medium. Therefore, the enkephalin-degrading peptidases, present in the seminal fluid, would play a key role in sperm motility.58 Throughout the female oviduct the human sperm obtains its fertilizing