Differential Responsiveness Of Monocyte And Macrophage Subsets To Interferon

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Chemokines: signal lamps for trafficking of T and B cells for

progenitor cells; ICAM, intercellular adhesion molecule; IFN-g, interferon-g; IGF-1, insulin-like growth factor-1; IL-7, interleukin-7; LFA-1, lymphocyte function-associated antigen-1; MAdCAM, mucosal vascular addressin cell

Supplement Review The instructive role of dendritic cells on

interferon-producing cells [IPC]) that instead express TLR9, which mediates the response to CpG DNA [14,15]. The differential responsiveness of myeloid and plasmacy-toid DCs to pathogens underlines a division of labour between human DC subsets. DC maturation can be also triggered by tumour necrosis factor (TNF)-α and IL-1, and can be inhibited


effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses. Blood. 1998 Oct 15;92(8):2668-71. 22. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray

Characterization of Human Blood Monocyte Subset

the monocyte subsets obtained were not sufficiently purified from other contaminating mononuclear leu-kocytes. In the present study, methods were developed for obtaining large numbers of two monocyte subsets by usingCCEandhumanserumalbumin(HSA)gradients in >90%purity in suspension, whichallowedextensive cytochemical and functional

Chemokines and the Arrest of Lymphocytes Rolling Under Flow

differential expression of CD45R isoforms (Fig. 2C) (37). Only CD4+ cells of the memory phenotype responded detectably to MIP-3ot, whereas both subsets responded to SDF-lot. Thus, subsets responded differen-tially to the proadhesive activity of chemo-kines. In this context, it should be empha-sized that minor subsets of circulating cells

The role of chemokines in the regulation of dendritic cell

(or CC) chemokines active on multiple subsets of mononuclear cells, including monocytes, granulocytes, lymphocytes, NK cells, and DC. Lymphotactin (g or C chemokine) and frac-talkine (d or CX3C chemokine) define two additional structural motifs of this superfamily [26, 28 30]. Virtually all cell types produce chemokines under appropri-

Environment Tunes Propagation of Cell-to-Cell Variation in

Variation in the Human Macrophage Gene Network Andrew J. Martins,1,7 Manikandan Narayanan,1,7 Thorsten Prustel,€ 2 Bethany Fixsen,1 Kyemyung Park,1,3 Rachel A. Gottschalk,4 Yong Lu,1 Cynthia Andrews-Pfannkoch, 1,8 William W. Lau,5 Katherine V. Wendelsdorf, 9 and John S. Tsang1 ,6 10 * 1Systems Genomics and Bioinformatics Unit 2Computational

REPORTS Chemokines and the Arrest of Lymphocytes Rolling

differential expression of CD45R isoforms (Fig. 2C) (37). Only CD41 cells of the memory phenotype responded detectably to MIP-3a, whereas both subsets responded to SDF-1a. Thus, subsets responded differen-tially to the proadhesive activity of chemo-kines. In this context, it should be empha-sized that minor subsets of circulating cells


mitogen responsiveness (6), in vitro antibody response to sheep RBCs (7), natural killer cell activity (8), expression of cell surface markers involved in lymphocyte activation (such as OKTIO, IL2 and Ia receptors) (9), monocyte chemotaxis (10), and macrophage cytotoxicity (11). Studies indicating that virus infected lymphocytes produce beta-

Temporal dynamics of inflammatory cytokines/chemokines during

involved in macrophage and lymphocyte recruitment, was significantly higher after 24 hours of Peg-IFN treat-ment in patients who achieved SVR, compared to those who relapsed.19,34,35 Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that recruits monocytes and T cells to areas of inflammation, and elevated

Shelter from the cytokine storm: pitfalls and prospects

tion of interferon-stimulated genes, and other inflammatory cytokines [30]. For Middle East respiratory syndrome (MERS)-CoV, the timing of type I IFN production appears to dictate the outcome of infection in mouse models, and its administration within 1 day after infection was protective against lethal infection, while a delay in IFN production

T Cell Chemokine Receptor Expression in Human Th1- and Th2

Selective responsiveness to chemokines is sug-g%ested by differential chemokine receptor expression o n human Th1 and Th2 clones and cell lines in vitro. U&nder often highly polarizing conditions and in re-sponse to polyclonal stimuli, human Th1 cell lines and c lones preferentially express CXCR3 and CCR5,

Dendritic Cell Immaturity during Infancy Restricts the

further divided into plasmacytoid and myeloid subsets based on differential expression of CD123 (plasmacytoid DC) and CD11c (myeloid DC). At least 150,000 mononuclear cells were acquired on the flow cytometer in order to obtain sufficient numbers of DC subsets for accurate enumeration, and the results are expressed as percentages of

Dendritic Cell Trafficking and Function in Rare Lung Diseases

DC (cDC) subsets in the periphery (13). Alternatively, MDPs give rise to common monocyte progenitors, which differentiate into circulating monocytes (14). Circulating Ly6C1 monocytes migrate into tissue or LNs via the HEV to either give rise to macrophages, if a niche is open, or differentiate into monocyte-derived DCs (moDCs) (15, 16). moDCs

Cord-Blood-Derived Professional Antigen-Presenting Cells

May 31, 2021 GM-CSF or macrophage colony-stimulating factor exposure, all monocyte subsets display macrophage (MF) morphology and cytokine profiles and enhanced phagocytosis, out- Int. J. Mol. Sci. 2021 , 22, 5923 3 of 25

Asian Zika virus strains target CD14+ blood monocytes and

(CD14lo CD16+) subsets12. In addition, monocytes can further differentiate into pro-inflammatory M1 or anti-inflammatory M2 macrophages11,13. While the fate of these monocyte subsets remains a subject of debate, findings from a mouse model of vascular inflammation have suggested that classical and non-classical monocytes are most likely to

GM-CSF overexpression after influenza a virus infection

mediators and moderates M1 macrophage pro-inflammatory signaling by Type II interferon (IFN- γ). Conclusions: Our data indicate that application of high levels of GM-CSF in the lung after influenza A virus infection alters pathogenic M1-like macrophage inflammation. These results indicat e a possible therapeutic strategy for respiratory


Effect of Monocyte Chemotactic Cytokine Gene Transfer on Macrophage Infiltration, Growth and Metastatic Behaviour of a Murine Melanoma 192 B. Bottazzi, S Walter, D. Govoni, F. Colotta, A. Mantovani Expression of Monocyte Protein 1 (MCP-1) by Monocytes and Endothelial Cells Exposed to Thrombin 193 F.L Sciacca, F. Colotta, M

th Annual Immunology Retreat - med.upenn.edu

HIV-1 infection modulates apoptosis-related genes in monocyte/macrophage in vivo 21. SM Grande, E Katz, JE Crowley, MS Bernardini, SR Ross, and JG Monroe ITAM-contaning proteins are oncoproteins in non-hematopoietic cells 22. Alice Hsu and Phillip Scott Reduced Th1 cell development following infection with Leishmania mexicana 23.

Supplemental Data Selective Expression of the Chemokine

Sozzani, S. et al. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. J. Immunol. 159, 1993-2000 (1997) human monocyte-derived DC Cao, X. et al. Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity.

Targeting Metabolism to Improve the Tumor Microenvironment

man macrophage phenotypes, and macrophage metabolism data have been largely derived from murine studies. Despite this, there appears to be a clear distinction between the meta-bolic programs of M1-like and M2-like TAMs, which could pose unique targeting strategies requiring further investigation in primary human macrophages (Al-Khami et al., 2017).

Enhanced Innate Immune Responsiveness to Pulmonary

interferon (IFN-), interleukin 12 (IL-12), and IL-18, as well as chemokines such as monocyte chemoattractant protein-1 (MCP-1/C-C motif ligand 2 [CCL2]) and macrophage inflam-matory protein-1-alpha (MIP-1/CCL3) in leukocyte recruit-ment and effective host defense (33) has been demonstrated. Conversely, the microbial pattern recognition

Cytokine profiles show heterogeneity of interferon-β response

These subsets differed significantly in their clinical and biological response to IFN-b therapy. Two subsets were associated with patients who responded poorly to therapy. Two other subsets, associated with a good response to therapy, showed a significant reduction in relapse rates and no worsening of disability. Each subset also had differential

Toxicologic Pathology Minipigs in Translational Immunosafety

standing human monocyte function (Fairbairn et al. 2011, 2013). However, the markers that distinguish mouse and human monocyte subsets cannot readily be applied to the pig (Fairbairn et al. 2013). Studies on monocyte subsets in the pig have utilized the differential expression of CD163 because of the role of CD163 in cellular entry into

Differential Expression of Chemokine Receptors and

The differential expres-sion of chemokine receptors may dictate, to a large extent, the migration and tissue homing of Th1s and Th2s. It may also determine different susceptibility of Th1s and Th2s to human im-munodeficiency virus strains using different fusion coreceptors. C D4 1 T cells can be subdivided into different subsets

CD4⁺ Lymphocyte Cell Enumeration for Prediction of Clinical

interferon-7, which are important in the growth, function, and differentiation of the cellular immune system [5]. Less commonly, CD4+ cells function as cytotoxic cells. The selec-tive loss of CD4+ cells results in numerous immune defects Received 16 July 1991; revised 11 October 1991.

Differential Extracellular Signaling Via FcγR and FMLP in

responded to interleukin-1, interferon-'}', bradykinin, substance P, or /32 integrin crosslinking. These results indicate that blood monocytes and in.filtrating macro­ phages differ substantially from LC in their responses to immune complexes and chemoattractants. Differential responsiveness to the inflammatory milieu may influ­

New Piece in the Jigsaw Puzzle: Adipose Tissue Derived Stem

monocyte-depleted MNC fractions barely produced IL-1b, while monocyte depletion did not affect IL-6 production, suggesting that monocytes are the main source of IL-1b but not IL-6. Altogether, these results suggest that the triumvirate of monocytes, ASCs, and T cells controls Th17-specific adipose tissue inflammation.

Review Therapeutic targets in systemic sclerosis

Differential pathogenesis in subsets of systemic sclerosis The clinical heterogeneity of SSc makes it likely that different pathogenic processes operate in different disease subsets. Diffuse cutaneous SSc (dcSSc) has a much more inflam-matory onset than does limited cutaneous disease (lcSSc). There is often widespread inflammation in the skin and

STAT3 in Tumor-Associated Myeloid Cells: Multitasking to

signaling, as observed independently in subsets of glioma and prostate tumors. As shown in Pten phosphatase-deficient cancer cells, STAT3 can acquire an unexpected role as a tumor suppressor [13,14]. Therefore, an additional level of caution is needed when designing strategies targeting Jak/STAT3 signaling in cancer cells.