Ibandronate Uptake In The Jaw Is Similar To Long Bones And Vertebrae In The Rat

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Oncologist®

by CL ESTILO Cited by 175 nates for cancer treatment include clodronate, ibandronate, pamidronate An exposed jaw bone in an area previously treated with 5,500 cGy.

Characterization of tissue properties on the sub-micron scale

by B Hesse 2014 Cited by 1 d'acquisition restent trop long pour envisager une application à des séries d'échantillons. Using a rat model, the uptake of BP in the jaw bone was found to be similar to the Bauss, F., Pfister, T. & Papapoulos, S. (2008) Ibandronate uptake in the jaw is similar to long bones patients with osteoporotic vertebral fracture.

Bisphosphonates

by RGG RUSSELL Cited by 466 phonates (such as pamidronate, alendronate, risedronate, ibandronate, and zoledronate) pathological calcification when given orally to rats in vivo.30 This property of buried in the bone is inactive at least as long as it remains buried there. They Uptake and distribution of BPs into different compartments of bone. This.

BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE

by V Thumbigere Math 2013 Cited by 1 Risk factors of Osteonecrosis of the Jaw in 576 Cancer Patients. Receiving including severe bone pain, pathologic fractures, spinal cord compression, and The skeletal uptake varies with age, sex and with the dose and nature of the well-recognized clinical entity in patients on long-term corticosteroid therapy.[117].

Imaging modalities for drug-related osteonecrosis of the jaw

that with long-term BP administration, the bone metabolism of the iliac crest and BP, i.e., alendronate, risedronate, minodronate, and ibandronate. ter that we termed the 'bone uptake value (BUV),' calculated as the the mandible, humerus, second and fourth lumbar vertebrae, iliac Anatomic site variability in rat.

Anatomic Site Variability in Rat Skeletal Uptake and - CORE

by D Wen Cited by 49 Bauss F, Pfister T, Papapoulos S. Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J Bone Miner Metab. 2008; 26:406 8. [PubMed: 

Jaw bone changes in rats after treatment with zoledronate and

3 Mar 2010 BPs such as zoledronate, pamidronate, ibandronate, alendronate, and remodeling and are sites of high BP uptake and accu- mulation.3,42 Recently, uptake in the jaw is similar to long bones and vertebrae in the rat.

Bisphosphonates - Mayo Clinic Proceedings

by MT Drake 2008 Cited by 1282 nous; OI = osteogenesis imperfecta; ONJ = osteonecrosis of the jaw; Like their natural analogue PPi, bisphosphonates have a very high ated uptake from the bone mineral surface.1 Intracellular (pamidronate, ibandronate, and zoledronic acid), which for the long-term effect of bisphosphonate treatment on main-.

bisphosphonates - Longdom Publishing SL

PMid:17075846. PMCid:2612758. 25. F. Bauss, T. Pfister and S. Papapoulos, Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat, J.

Pathogenesis of medication-related osteonecrosis of the jaw

by H Holtmann 2018 Cited by 20 ibandronate, and risedronate were the most frequent bisphosphonates used. MRONJ was most After uptake into the cell, the latter interfere with Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J Bone Miner 

Analysis of bone activity of jaws using scintigraphy on patients

by NQ Handoo 2009 Effect of base grade on the odds ratio of having a higher grade by jaw. 67 uptake in the cervical spine is seen which was superimposed on the This same definition is used by the American Society of Bone and Mineral exposure to these medications, and long term follow-up of these patients, it is likely that.

Effect of Bisphosphonates on Periodontal Disease in Rice Rats

by JS Callard 2013 alendronate (Fosamax), ibandronate (Boniva), and zoledronic acid (Zometa). Trabecular bone is less dense and is found at the end of long bones and the The risk of having a new vertebral fracture reduced by 41-49% [33- patients on corticosteroid therapy had similar results, and concluded that there was a 70%.

Bisphosphonate-Related Osteonecrosis of the Jaw: Is pH the

by S Otto 2010 Cited by 174 Discov Mol Cell Evol Biol 288:1243, 2006. 27. Bauss F, Pfister T, Papapoulos S: Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat.

TISSUE ENGINEERED BONE USING SELECT - eCM Journal

by D Gothard Cited by 169 sheep long bone fractures as a model for large bone defects in humans, where the scale, mechanical loading and bone composition are similar to humans.

Ibandronate uptake in the jaw is similar to long - ProQuest

by F Bauss 2008 Cited by 52 Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. Abstract Intravenous bisphosphonates may be involved in the development of 

Bisphosphonates in Chronic Kidney Disease - CJASN

for Transplant and Renal Research, Westmead Millennium Institute and Bone and Mineral Program, Garvan Institute Very high doses of other bisphosphonates can have similar contribute to high rates of hip and vertebral fracture (33 35). In nephrectomized rats, ibandronate prevented Osteonecrosis of the Jaw.

Bisphosphonates - American Academy of Pediatrics

nate, risedronate, ibandronate, and zoledronate) inhibit a key enzyme, farnesyl Like pyrophosphate, bisphosphonates had high affin- ied in the bone is inactive for at least as long as it remains rectly.25 The uptake of bisphosphonates by osteoclasts in mass and maintains bone quality of lumbar vertebrae in rats.

Short-term effect of zoledronic acid upon fracture resistance of

by F Camacho-Alonso Cited by 215 shown that in rats given different doses of ibandronate, the uptake of this bisphosphonate in the mandible is relatively similar to that seen in other bones Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J Bone 

Bisphosphonate osteonecrosis of the jaw - Exodontia.Info

by NMH McLeod 2011 Cited by 98 (absorption of ingested dose is only in the order of 10%) and excreted largely unchanged Bauss F, Pfister T, Papapoulos S. Ibandronate uptake in the jaw is similar to longbones and vertebrae in the rat. J Bone. Miner Metab 

Common Technical Document Ibandronate 1 mg/ml (as

cancer and bone metastases is 6 mg intravenous injection given every 3-4 weeks. The dose should be infused over at least 15 minutes. For infusion, the 

Osteonecrosis of the jaw (ONJ) - TSpace - University of Toronto

by C Forster Cited by 2 Bisphosphonate-induced osteonecrosis of the jaw (BPONJ) has been identified as a I would also like to thank everyone in the CIHR Group in Matrix Dynamics. alendronate, ibandronate, risedronate and zoledronate) are not metabolized by osteoclasts C. Targeting of Bisphosphonates to Bone and Cellular Uptake.

BONIVA (ibandronate) Injection - US Food and Drug

women with osteoporosis, BONIVA increases bone mineral density (BMD) and reduces the incidence of vertebral fractures [see Clinical Studies(14)]. bisphosphonates have been associated with osteonecrosis of the jaw (ONJ), perform a routine oral safety and tolerability profiles of the two dosing regimens were similar.

MRONJ - BMC Oral Health

by BT Ozyurtseven 2021 Medication-related osteonecrosis of the jaw (MRONJ) emerges as an important ibandronate uptake is not different in jaw compared to long bones and vertebrae. Morris et promotion of bisphosphonate-induced osteonecrosis in Wistar rats.

[188Re]Re- ibandronate - Research Square

And the third-generation bisphosphonates ibandronate (IBA) has higher bone a and bone imaging in New Zealand rabbits showed high bone uptake, long Furthermore, it may be accompanied by pathological fractures, spinal cord compression, jaw[14]. The choice of drugs with lower toxicity is an important factor in 

Glucocorticoid-induced osteoporosis: an overview - Open

Keywords: bisphosphonates bone mineral density glucocorticoids monitoring. osteoporosis overall for long-term GC treatment were Calcium uptake ↓ same BMD, the risk of osteoporotic fractures is higher fracture after the age of 50 years, prevalent vertebral Ibandronate, which is given once monthly orally,.

Review A review of bone pain relief with ibandronate and

by JD Ringe 2007 Cited by 39 Bone pain relief with ibandronate / J.D. Ringe & J.J. Body resorption A study in a rat model of similar whether the pain is due to ma- lignant or lished osteoporosis due to long-term, in mean lumbar spine and femoral neck. BMD (p increased 99Tc uptake on bone scan, rosing osteomyelitis (DSO) of the mandible.

spontaneous bisphosphonates osteonecrosis of jaw - Wiley

27 Nov 2009 producing a 4 mm-diameter bone defect on the same site. After 7 weeks from the the bone defect and a normal uptake of the contrast medium during the scan. The Bauss F, Pfister T, Papapoulos S. Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J Bone Miner Metab 2008; 

Published version - Article Reference

by N Bonnet 2013 Cited by 34 concurring to the loss of jaw alveolar bone and finally of teeth. both in the long bones and in deep jaw alveolar bone, without differences high doses of zoledronate in rats (66 mg/kg, i.e equivalent to Bauss F, Pfister T, Papapoulos S (2008) Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat.

ibandronate sodium - BONIVA - US Food and Drug

Take one 150 mg tablet once monthly on the same day each month (2.1) increases bone mineral density (BMD) and reduces the incidence of vertebral fractures. and calcium may interfere with the absorption of ibandronate sodium (see DRUG Patients who develop osteonecrosis of the jaw while on bisphosphonate 

Oral health and bisphopshonate-associated jaw osteonecrosis

by CE Tsao 2012 Anti-resorptive drugs, including bisphosphonates, reduce bone turnover and have been associated with exposed necrotic jaw bone called jaw osteonecrosis 

Long-term treatment with bisphosphonates and their safety in

by M Pazianas 2010 Cited by 138 the jaw (ONJ) has also been suggested. However, the The oral iBandronate Osteoporosis vertebral fracture trial in North mineral that prevents their uptake by most other tissues, even jaw is similar to long bones and vertebrae in the rat.

Bonviva, INN- ibandronic acid - European Medicines Agency

1 Apr 2005 ADME studies were performed in the rat, dog and monkey and aminobisphosphonates: A very low absorption rate from the GI tract, a high of the administered ibandronate is located in bone with a very long days resulted in similar concentrations of ibandronate in vertebrae Osteonecrosis of the Jaw.

Changes in dimension of neurovascular canals in the

by D Goller-Bulut Cited by 8 Therefore, CBCT can inves- tigate sclerotic changes in the spongious bone of the jaw, Bauss F, Pfister T, Pappapoulos S. Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J Bone Miner Metab.

Diagnosis and Management of Osteonecrosis of the Jaw: A

pathophysiology, diagnosis, and treatment of osteonecrosis of the jaw (ONJ), same disease as exposed ONJ and further recommended that developed in the long-term treatment group with patients radiation therapy to bone; surgery to bone; and spinal increased uptake in the jaw, including tumor or periodontal.

Boneв 'siteв 'specific responses to zoledronic acid - Wiley

ferent effect on long bone and jaw osteoclasts, and on the turnover of these Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat. J.

Effects of antiresorptive agents on inflammation and - GUPEA

by C Cardemil 2014 demonstrated in the long bones of the ovariectomised rat, less structural alterations were site differences, osteonecrosis of the jaw, osseointegration, bone substitute, inflammation and Hydroxyapatite Granules Promote Different. Inflammatory Bauss F, Pfister T, Papapoulos S. Ibandronate uptake in the jaw is similar to 

Bisphosphonate treatment: An orthodontic concern calling for

2007 Cited by 118 in the alveolar bones of the maxilla and the mandible. Common Vertebral, thoracic, pelvic, hip, and by intracellular uptake of the drug, which decreases pamidronate administration to rats over 5 days to group is variable but can be extremely long: ibandronate, Bisphosphonate osteonecrosis is strikingly similar.

BONIVA (ibandronate sodium) - It works!

In postmenopausal osteoporosis, bone resorption exceeds bone formation, leading to bone loss and increased risk of fracture. After menopause, the risk of 

The Silent Thief - CEConnection

by M Kamienski 2011 Cited by 21 tibility to fractures, especially of the hip, spine, and wrist, although any bone can be affected. In simpler terms, osteoporosis is a condition in which the bones.

Changes in Cortical Bone Mineral and Microstructure with

cylindrical structure like the diaphysis (shaft) of a long bone (Fig. 1), the theo- common fracture sites are the vertebra, distal radius and proximal femur. We focus of very high calcium absorption during growth [45], which allows for rapid modeling and Rotated plywood structure of primary lamellar bone in the rat:.

Management of the adverse effects associated with

by T Tanvetyanon 2006 Cited by 337 Patients who receive long-term pamidronate should be evaluated at osteonecrosis of the maxilla and mandible, obtaining a full dental Pamidronate, ibandronate, and zoledronic acid are the most for hypercalcemia of malignancy and bone metastases from avid calcium uptake into bone [84].

A. MORBIDITY AND MORTALITY Fractures give rise to pain

Long-term morbidity is associated with almost all types of symptomatic In this article, we explore different pharmacological leading to decreased bone strength, increased bone fragility and diagnosed fractures, or have radiographic evidence of vertebral osteoporosis (Alendronate, Ibandronate, Risedronate and.

Is GERD a Factor in Osteonecrosis of the Jaw? Evidence of

by S Seneff 2016 Cited by 1 Osteonecrosis of the jaw (ONJ), a rare side effect of bisphosphonate therapy, is a debilitating disorder with a [6] F. Bauss, T. Pfister, and S. Papapoulos, Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat, Journal.

RACGP Osteoporosis prevention, diagnosis and management

following minimal trauma (equivalent to a fall from standing height or less). Postmenopausal Measure bone mineral density (BMD) by dual energy X-ray absorptiometry vertebral fractures are considered to be the major osteoporosis risk (on the for subsequent fractures and mortality: A long-term prospective study.

Bisphosphonates: therapeutics potential and recent advances

by M Fazil 2015 Cited by 65 from 0.6 to 1% due to poor absorption through gastrointestinal tract (GIT). Objective: The main treatment in bone resorption and other bone disorders like.

Bone Scans, Bisphosphonates, and a Lack of Acute Changes

by PG Morris 2011 Cited by 10 Purpose: The etiology of osteonecrosis of the jaw is poorly understood, but preferential mandibular uptake of intravenous bisphosphonates (IVBPs) has been implicated. We examined this clinical modeling with rats treated with ibandronate, no suggestion is similar to long bones and vertebrae in the rat. J Bone Miner.

Chapter 3 - VU Research Portal

Bone-site-specific responses to bisphosphonates: Long bone and jaw compared. Also, BP treatment induced signs of ONJ in rat models for Papapoulos S. Ibandronate uptake in the jaw is similar to long bones and vertebrae in the rat.

Download PDF - eScholarship

in patients taking anti-resorptives for osteoporosis, bone malignancies, and bone metastases, the the Jaw (ONJ) in Rats with Experimental Periodontitis MicroCT and histomorphometric analysis of lumbar vertebrae colleagues used long-term antibiotics in an attempt to treat ONJ; however, had little success,.

Diagnosis and Management of Osteonecrosis of the - AUB

pathophysiology, diagnosis, and treatment of osteonecrosis of the jaw (ONJ), and infected resulting in a clinical picture similar to osteomyelitis. developed in the long-term treatment group with patients radiation therapy to bone; surgery to bone; and spinal increased uptake in the jaw, including tumor or periodontal.

BISPHOSPHONATES IN DENTISTRY AN ASIAN - IJCRR

by VK Naik 2014 200855 suggesting similar uptake of ibandronate by spine, femur and jaw uptake in the jaw is similar to long bones and vertebrae in the rat.