Carcinosarcoma Of The Breast

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Cases Journal BioMed Central

Carcinosarcoma of the breast, often referred to as metaplastic carcinoma of the breast, is a rare malignancy with two distinct cell lines described as a breast carcinoma of ductal type with a sarcoma-like component. Clinically, carcinosarcoma of the breast is an aggressive breast cancer.

Survivorship Endometrial Cancer Page 1 of 4

3 Uterine carcinosarcoma CA-125 annually 5 Includes breast, cervical (if appropriate), colorectal, liver, lung, pancreatic, and skin cancer screening

Carcinosarcoma of the Breast - JCPSP

Breast cancer is a heterogeneous disease with regard to histopathological types. The most common histo-pathology is infiltrating ductal carcinoma, which accounts for about 80% of all breast cancers.5 Carcinosarcoma of the breast is an aggressive and rare neoplasm. Its reported incidence is 0.1% of all breast malignancies.6 Carcinosarcoma breast

Carcinosarcoma of the Breast - Case Reports

Carcinosarcoma of the breast is a malignant sarcomatoid metaplasia of epithelial carcinoma and is rare. It is an aggressive tumor constituting less than 1% of all breast cancers. It accounts for 0.08% - 0.2% of all malignant breast lesions. Wargotz and Norris suggested that carcinosarcoma of the breast, in which an epithelial-mesenchymal transition

Metaplastic Breast Cancer: To Radiate or Not to Radiate?

Metaplastic breast cancer (MBC) is characterized by the histologic presence of 2 or more cellular types commonly representing a mixture of epithelial and mesenchymal components.1 6 MBC represents 0.25 1% of breast cancers diagnosed annually.1,7,8 The prognosis of and optimal treatment for MBC are largely unknown. Review of more

Sarcomatoid/metaplastic carcinoma of the breast: a

as carcinosarcoma ,8 10 carcinoma with pseudo-sarcomatous stroma ,11,12 spindle cell carcinoma 13 16 and in the female genital tract malignant mixed mullerian tumour 5 In the breast, this tumour is often called metaplastic carcinoma 1,17,18 In spite of the differences in terminology in different organ systems,

Cancer Programs Practice Profile Reports (CP3R) Rapid Quality

Aug 06, 2019 Early Breast Cancer Trialists Collaborative Group (EBCTCG), et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: Meta-analysis of individual patient data for 10,801 women in 17 randomized trials.

Metastatic Uterine Carcinosarcoma: A Case Report and

uterine carcinosarcoma (UCS), demonstrating S-100 protein Abstract Uterine carcinosarcoma (UCS) is a highly aggressive malignancy with a poor prognosis. Metastasis of UCS is seen most frequently in the abdomen, pelvis and lungs. This report discusses a rare case of a post-menopausal female with recurrent UCS who was diagnosed with

Paclitaxel Couplets With Cyclophosphamide or Cisplatin in

Metastatic Breast Cancer Anthony W. Tolcher Determining active combinations containing paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) to treat metastatic breast cancer has been the focus of recent clinical development. Paclitaxel combined with either cyclophosphamide or cisplatin has several poten­

The CD49d+/high subpopulation from isolated human breast

carcinosarcoma and fibromatosis of the breast (14). Despite significant advances in medical and surgical management, these tumors have no suitable therapeutic modalities, and are associated with high risk of recurrence and poor prognosis. Therefore, clarification of their molecular features is critical

The reasonable timing of the adjuvant radiotherapy in the

to breast cancer before a diagnosis of carcinosarcoma. The median interval between breast cancer surgery and carcino-Fig. 1. Kaplan-Meier curves for progression-free survival rate (A) and overall survival rate (B) of carcinosarcoma patients after surgery or biopsy.

Mammary Gland Carcinosarcoma in a New Zealand White Rabbit

Background: Carcinosarcoma of the breast (metaplastic, biphasic metaplastic, metaplastic sarcomatoid carcinoma, sarcomatoid carcinoma) is an aggressive, rare neoplasm that has been reported to account for 0.08-0.2% of all breast malignancies. Mammary carcinosarcoma is rare in rabbits. Carcinosarcoma is a neoplasia composed of cells morphologi-

Metaplastic Carcinomas of the Breast

All lesions of the breast coded as carcinosarcoma, metaplastic carcinoma, spindle cell carcinoma, carcinoma with spindle cell, osseous, or chondroid metaplasia, or From the Department of Breast and Gynecologic Pathology, Armed Supported by the American Registry of Pathology, Washington, DC.

Primary peritoneal carcinosarcoma (malignant mixed mullerian

breast and axillary lymph node dissection. Pathology revealed a well-differentiated and invasive ductal carcinoma. The axillary lymph nodes were free of tumor. An immunohistochemical study detected no estrogen and progesterone receptors and no HER-2/ neu protein. Due to strong family history of breast and ovarian cancer, the patient underwent

Extragenital Malignant Mixed Mullerian Tumor in the

occurring after tamoxifen therapy in breast cancer [8]. The most common sites of metastasis are lungs and the abdominal cavity. Extragenital primary Mullerian carcinosarcoma is ex-tremely rare. Ober and Black [9] in 1955 reported the first extragenital MMMT, however there have been less than 50 reports in the English literature about this entity.

57 year old woman with a large left breast mass protruding

Metaplastic Breast Carcinoma Also known as spindle cell carcinoma of the breast (SpCC). Rare form of primary breast malignancy (< 5% of breast CAs). Epidemiology: Usually seen in women who are more than 50 years old with average age at diagnosis ~55 years. Clinical presentation Palpable mass lesion (often rapidly growing).

A case of breast carcinosarcoma with associated

Metaplastic breast carcinomas are histologically heterogeneous and rare tumours constituting <1% of breast malignancies. We present here a case of carcinosarcoma consisting of a predominant sarcomatous component and a minor component of squamous cell carcinoma, a combination seen in <5% of metaplastic breast carcinomas. The presence of

12-Case Report metaplastic carcinoma of Breast

breast, an intriguing rarity. Asian Pac J Cancer Prev. 2006;7(4): 667-71. 2. Patrikar A, Maimoon S, Mahore S, Akhtar MA, Wilkinson A. Metaplastic carcinoma of breast (carcinosarcoma variant): a case report. Indian J Pathol Microbiol 2007; 50 (2): 396-98. 3. Gogas J, Kouskos E, Markopoul C, Mantas D et al. Carcinosarcoma of the breast ; report

REVIEW Open Access Metaplastic breast cancer: histologic

Keywords: Metaplastic breast cancer, Metaplastic, Basal like breast cancer, Carcinosarcoma Introduction Metaplastic breast cancer (MBC) is a rare and histolog-ically diverse subtype of breast carcinoma. It accounts for less than 1% of all breast cancers [1,2]. MBC was not officially recognized as a distinct histologic entity

ONCOLOGY Posttreatment surveillance and diagnosis of

ONCOLOGY Posttreatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncologists recommendations

Carcinosarcoma of the Breast in a Pregnant Patient: A Case

Breast carcinosarcoma is a rare tumor of the breast consisting of 0.08 to 0.2% of all cases of breast cancer [1]. The incidence of this type of tumor is very low and in this case the patient presented with the malignancy

NCCN Clinical Practice Guidelines in Oncology (NCCN

The AJCC Staging 7th Edition Cancer Staging Tables were updated to the 8th edition for uterine carcinomas and carcinosarcoma, as well as uterine sarcoma (ST-1) The Discussion has been updated to reflect the changes in the algorithm (MS-1). Endometrial Carcinoma: ENDO-1

Case Report Cytogenetic aspects of a canine breast

Cytogenetics of a breast carcinosarcoma canine 3 Genetics and Molecular Research 16 (2): gmr16029433 the chromosomal identification, difficult factors in dogs highlight the high diploid number (2n = 78) associated with the similarity of size and banding patterns of smaller autosomes (Breen et al., 2001).

Ovarian Carcinosarcomas Associated With Prolonged Use of

breast carcinoma and or prolonged use of tamoxifen. These cases may suggest that like in the uterus, tamoxifen has a possible delayed effect, which might be responsible for the formation of aggressive tumors of unclear pathogenesis in the ovaries. Key Words: Ovarian carcinosarcoma, Tamoxifen, Breast carcinoma (Int J Gynecol Cancer 2009;19

CASE REPORT Open Access Mixed epithelial and mesenchymal

Keywords: metaplastic breast cancer, carcinosarcoma, treatment, progonosis Background Metaplastic breast carcinoma (MBC) is a rare and heteroge-neous group of malignancies that constitutes less than 1% of all breast cancers [1-3]. The World Health Organization recognized and classified metaplastic carcinoma in 2003 [4].

Metaplastic Breast Cancer: Clinical Overview and Molecular

carcinoma Carcinosarcoma Sarcomatoidcarcinomaofthe breast Introduction Metaplastic breast cancer [1, 2] (MpBC) is a rare subtype of breast cancer, accounting for less than 1 % of all breast ma-lignancies. MpBC was officially recognized as a distinct his-topathologic subtype by the World Health Organization in

A rare malignant thyroid carcinosarcoma with aggressive

Background: Malignant biphasic tumor also known as carcinosarcoma is an uncommon neoplasm that is composed of both malignant epithelial and mesenchymal components. Most reported cases of carcinosarcoma affect the female genital tract; however, other sites including head and neck, lung, and breast have been described. Carcinosarcoma of

Research articleBilateral downregulation of Nav1.8 in dorsal

Walker 256 carcinosarcoma breast cancer cells were kindly provided by the Shanghai Institute of the Pharma-ceutical Industry. They were prepared and developed as previously described [20]. In brief, Walker 256 tumor cells were obtained from an ascitic tumor-bearing rat and collected by centrifugation of 2 mL of ascitic fluid for 3 min at 1200 rpm.

Metaplastic Carcinoma of the Breast: A Diagnostic Dilemma

carcinoma, squamous cell carcinoma and carcinosarcoma. [4] Oberman categorized them as MC of the breast despite the presence of overlapping microscopic features.[5] Oberman and Pitts reported lack of correlation between microscopy and prognosis.[5,6] However, some of the authors observed poor prognosis in those with carcinosarcoma. The etiology

Uterine carcinosarcoma/malignant mixed Müllerian tumor

Fig. 1. Kaplan-Meier estimates of time to uterine carcinosarcoma/ malignant mixed Müllerian tumor (UC/MMMT) following breast cancer diagnosis, with and without hormone therapy for the breast cancer. There is no difference between the groups. 0 1.0 25 Time from diagnosis of breast cancer to UC/MMMT (yr) Hormone therapy No hormone therapy 51 02

A Rare Case of Breast Carcinosarcoma with Lymphatic Metastasis

Introduction and Patient Profile: Carcinosarcoma of the breast is a rare malignancy composed of two cell lines described as a ductal-type carcinoma with a sarcoma-like component. It is an aggressive neoplasm that is usually larger in size than epithelial breast cancers and characterized by a rapid increase in size.

Exceptional Response of Cryoablation Followed by

tumor mutational burden-high metastatic cervical carcinosarcoma. † The case exhibited an exceptional response (maintained CR as of the time of submission of this article: 11 months) to cryoablation followed by pembrolizumab. † This is the first POLE-mutated cervical carcinosarcoma case. INTRODUCTION

REVIEW ARTICLE Energy metabolism in tumor cells

and AS-30D, breast carcinosarcoma Walker 256, hepatocellular carcinoma HC-252, hepatoma induced by dimethylazobenzene and DS-carcinosarcoma [1]. In human tumors, classification is based on their histological characteristics and stage of clinical pro-gression. By their advanced developmental stage and metastatic properties, some human tumors

Significant Tumor Response to the Poly (ADP-ribose

Carcinosarcoma Harboring a Germline RAD51D Mutation INTRODUCTION BRCA1 and BRCA2 are the best-known exam-ples of proteins that contribute to repair of double-strand DNA breaks via the homologous recombination repair (HRR) pathway. The RAD51 paralogs RAD51B, RAD51C, and RAD51D are proteins that are also involved in the HRR pathway. They act by

Clinical outcomes and patterns of care in the treatment of

Purpose: Carcinosarcoma of the breast is a rare yet highly aggressive tumor ac-counting for <1% of all breast cancers, for which guidance on optimal management and prognosis are sparse. The purpose of this study was to investigate population‐ based treatment patterns and overall survival (OS) outcomes in patients with this diagnosis.