Autoimmune Haemolytic Anaemia Prognosis Syndrome Definition

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Gavin Giovannoni

Haemolytic anaemia Goodpasture s ITP Syndrome Bullous Pemphigoid Immune neutropenia Grave s orbitopathy Neonatal hyperthyroidism Acquired Haemophilia Pernicious Anaemia Pure red cell aplasia Etc Cervical dysplasia4 MGUS 4 + 10% pre/malignant 6.1 yrs FUp Live vaccines Hypersensitivity pneumonitis

Management strategies and future directions for systemic

Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the loss of self-tolerance and formation of nuclear autoantigens and immune complexes resulting in inflammation of multiple organs. The clinical presentation of SLE is heterogeneous, can involve one or more organs, including the skin, kidneys, joints, and


course and prognosis.1Lupus erythematosus is a multisystemic disease affecting primarily the skin, but may also cause severe multivisceral disorders, with reserved prognosis.2 In terms of gender distribution, there is a predominance of the disease in women (female/male ratio = 9/1).3 The cause of the disease is not fully understood.

Cardiology Streptococcus bovis

small cell: ADH, ACTH, Lambert-Eaton syndrome Patients with Sjogren's syndrome have an increased risk of lymphoid malignancies Philadelphia translocation, t(9;22) - good prognosis in CML, poor prognosis in AML + ALL Polycythaemia rubra vera - JAK2 mutation Polycythaemia rubra vera - around 5-15% progress to myelofibrosis or AML

New Developments in Chronic Lymphocytic Leukaemia Diagnosis

the time of diagnosis, with clinically apparent autoimmune haemolytic anaemia being less frequent.12 The lymph nodes show involvement by Delgado AMc.indd 114 07/02/2014 17:38 DOI: 10.17925/EOH.2013.09.2.114

CLINICAL Antinuclear antibody test - RACGP

of haemolytic anaemia, thrombocytopaenia, The antinuclear antibody (ANA) test is widely used as a serological marker of autoimmune disease. Antinuclear antibodies are immunoglobulins or antibodies that bind to one or more antigens expressed within the nucleus of human cells. Used selectively, the ANA test can be a useful laboratory tool to

HK J Paediatr (new series) 2001;6:57-62 Postgraduate Column

Abstract Haemolytic uraemic syndrome is characterized by the triad of microangiopathic haemolytic anaemia, thrombocytopenia and acute renal failure. It is a common cause of acute renal failure in infants and young children. Diarrhoea-associated haemolytic uraemic syndrome is most commonly caused by E. coli 0157:H7.

Review Immune ablation and stem-cell therapy in autoimmune

improvement in coexisting autoimmune disease after HSC transplantation for conventional indications, such as aplas-tic anaemia, leukaemia and cancer [3]) has allowed the concept to move forward to the clinic. Haematopoietic stem-cell transplantation HSCs that are capable of replenishing the whole haematopoietic and immune system can be obtained

Index []

anaemia aplastic 51 autoimmune haemolytic 51 haemodialysis patients 243 haemolytic 40,51,272 iron deficiency 32,36-7 megaloblastic 3940 pernicious 41 anaesthesia 20-1 in asthmatic patients 10 gastrointestinal disorders 351-2 HELLP syndrome 297 anal fissure 375 anal sphincter injuries 375-6 analgesia in asthmatic patients 10

Chronic liver disease (CLD) - compensated Definition of

Definition of chronic liver disease (CLD) Progressive destruction of the liver parenchyma over a period greater than 6 months leading to fibrosis and cirrhosis Epidemiology of chronic liver disease (CLD) Literature on the incidence and prevalence of liver cirrhosis is scarce but figures suggest that around

SGM Proactive aTTP Disease Awareness Final

Microangiopathic, Haemolytic Anaemia (MAHA) Fatigue, weakness and dyspnea Thrombocytopenia (<30x109/L) Bleeding such as skin and mucosal hemorrhage (purpura, petechiae, ecchymosis, menorrhagia, bruising or epistaxis) Organ Ischemia Brain (headache, confusion, stroke, coma, seizures), Renal

Snakebite associated thrombotic microangiopathy: a protocol

microangiopathic haemolytic anaemia and thrombocytopenia. Available studies are predominantly small retrospective observational studies only. Renal end organ injury appears common. It has variably been likened to either thrombotic thrombocytopenic purpura or atypical haemolytic uraemic syndrome. Many studies report acute

Canine Immune-Mediated Hemolytic Anemia

What is the prognosis with IMHA? IMHA carries a fair prognosis in most cases, with published survival rates ranging from 50% - 80%. While anemia itself does not usually prove fatal, the complications of IMHA can be. Thromboembolic disease is the most life-threatening complication of IMHA, with survival rates dropping significantly in these

Presentation of Jaundice Pathophysiology of jaundice

Autoimmune haemolytic anaemia Drugs o Penicillins o Sulphasalazine Infections o Malaria Mechanical o Metallic valve prostheses o DIC Transfusion reactions Paroxysmal nocturnal haemoglobinuria Hepatic causes of jaundice Conjugated causes:

Clinical Practice Guidelines - USMF

Definition and clinical course of ALF *Patients with an acute presentation of chronic autoimmune hepatitis, Wilson disease and Budd Chiari syndrome are considered as having ALF if they develop hepatic encephalopathy, despite the presence of a pre-existing liver disease in the context of

Idiopathic CD4 Lymphocytopenia Diagnosis and Management of

antiphospholipid antibody syndrome (associated with deep venous thrombosis and pulmonary embolism), psoriasis, autoimmune thyroiditis, SLE, arthritis, autoimmune haemolytic anaemia, ulcerative colitis, vitiligo, Erosive lichen planus of the scalp and Bechet s-like syndrome.

Chronic hepatitis - BMJ

associated with the sicca syndrome, arthralgia, thyroid disease, haemolytic anaemia, inflammatory boweldisease, and renal tubular acidosis.4 Smooth muscle and antinuclear antibodies are typically found in the serum, and there is usually a greater degree of hypergammaglobulinaemia than in patients with chronic viral infection. Theseimmunological

PULMONARY HYPERTENSION Updated classification and management

Chronic haemolytic anaemia There is growing evidence that chronic hereditary haemolytic anaemias, including sickle cell disease (SCD), thalassaemia, hereditary spherocytosis, stomacytosis, and microangiopathic haemolytic anaemia, are today associated with PAH. It is esti-mated that PAH occurs most frequently in patients with SCD.


The direct antiglobulin test (Coomb's) is positive if there is autoimmune haemolytic anaemia. It is used to detect IgG or C3 bound to the surface of the red cell. Immune causes of hemolysis including autoimmune hemolytic anemias, drug induced hemolysis, and delayed or acute hemolytic transfusion reactions are characterized by a positive DAT.


Anti-phospholipid syndrome APS is an autoimmune disease characterized by the presence of anti-phospholipid antibodies (aPL) and various clinical manifestation related to arterial or venous thrombosis It can be further divided into primary and secondary APS Making the diagnosis requires both clinical and laboratory criteria

REVIEW Acute liver failure - BMJ

Jun 24, 2004 Coomb s negative haemolytic anaemia and demonstrable Kayser-Fleischer rings in most cases. Poisoning with Amanita phalloides (mushrooms) is most commonly seen in central Europe, South Africa, and the west coast of the United States. Severe diarrhoea, often with vomiting, starts five or more hours after ingestion of the mushrooms and liver failure

An Atlas of Left Atrium for Electrophysiology Beginners

those of the anaemic, purpuric and/or infiltrative syndrome (adenopathies, splenomegaly, hepatomegaly) [1]. Up to 35% of patients develop a direct positive Coombs test in the course of their disease. Approximately 10-20% of patients develop autoimmune haemolytic anaemia and, 2-3% develop autoimmune thrombocytopenia [17,18].

Splanchnic Vein Thrombosis: Risk Factors, Clinical

neoplasms or haemolytic anaemia [24]. Among the systemic risk factors myeloproliferative neoplasms are the primary cause of PVT, since they are found in one third of the patients [10-12,22,25]. A recent meta-analysis concerning prevalence of inherited factors in patients with PVT, showed a 4.5-fold and

Hemolytic Anemia

by antierythrocyte antibodies, can be secondary to malignancies, autoimmune disorders, drugs, and transfusion reactions. Microangiopathic hemolytic anemia occurs when the red cell membrane is damaged in circulation, leading to intravascular hemolysis and the appear-ance of schistocytes.

Male vs Female Lupus - UAB Barcelona

haemolytic anaemia, leucopenia, lymphopenia, thrombopenia, Sjögren´s, antiphospholipid syndrome (APS) and myositis. We reviewed serological data notably antinuclear antibodies (ANA) measured by indirect immunofluorescence using Hep-2 as the substrate (positive ANA at ≥ 1:80), rheumatoid factor (RF) measured by the latex test and

Diagnostic challenges Systemic lupus erythematosus

The most frequent haematological manifestation of SLE is anaemia.20 This is usually due to chronic inflammation, but sometimes an autoimmune haemolytic anaemia can be demonstrated. Leukopenia, such as lymphopenia or less commonly neutropenia, is also well recognised, but it rarely predisposes to infections. Thrombocytopenia

A recalcitrant case of cicatricial pemphigoid

reversible haemolytic anaemia and leukopaenia. Cicatricial pemphigoid can be rapidly progressive, as in our case, and the early combined use of oral prednisolone and oral cyclophosphamide (1-2 mg/kg/day) may prevent disease progression and complications.9 However, there are significant risks with this therapy

Orphanet Journal of Rare Diseases

Definition/Diagnostic criteria Systemic lupus erythematosus (SLE) is a clinically hetero-geneous disease which is autoimmune in origin, and char-acterized by the presence of autoantibodies directed against nuclear antigens. It is, by definition, a multi-sys-tem disease, and patients can present in vastly different ways.

Orphanet Journal of Rare Diseases

Definition Primary sclerosing cholangitis (PSC) is a chronic choles-tatic liver disease of intra and/or extrahepatic bile ducts. A concentric obliterative fibrosis occurs which leads to bile duct strictures, which in turn can progress to biliary cir-rhosis and liver failure. Cholangiocarcinoma develops in 8 30% of patients [1,2].


PNH: Can transform into aplastic anaemia or leukaemia. HS: Gallstones, aplastic anaemia in parvovirus infection, megaloblastic and haemolytic crises ( folate due to hyperactive bone marrow), leg ulcers and corneal opacities. PROGNOSIS Depends on the cause. ANAEMIA, HAEMOLYTIC 7

Cancer Prone Disease Section

WAS. Patients with XLT by definition have minimal immunological disturbances. Autoimmune diseases are frequent, the most common being haemolytic anaemia, thrombocytopaenia, neutropaenia followed by vasculitis, renal disease, Henoch-Schonlein-like purpura, and inflammatory bowel disease. Incidence of autoimmune disease is less

Jenny Lee Medical Oncologist - ANZSN ASM

haemolytic anaemia with splenectomy Arterial hypertension, T2DM Hypertension, CCF, T2DM, CKD, nephrectomy Glomerulonephritis Hypertension, T2DM Cause of renal insufficiency Light chain cast nephropathy Hypertensive nephropathy All of the above haemodialysis Glomerulonephritis haemodialysis Diabetic nephropathy haemodialysis

HEROLD's Internal Medicine (Second Edition)

AIHA Autoimmune haemolytic anaemia AN Autonomic neuropathy ANA Anti nuclear antibodies ANCA Anti neutrophile cytoplasmatic antibodies ANP Atrial natriuretic peptide A.O. And others APC Activated Protein C APS Antiphospholipid syndrome APPROX Approximately ARDS Adult respiratory distress syndrome ARF Acute renal failure

Diagnostic approach to microangiopathic hemolytic disorders

ment dysregulation,seen in shigatoxin-related hemolytic-uremic syndrome(Stx-HUS) and complement-mediated TMA (also called atypical hemolytic-uremic syndrome), respec-tively.Distinguishingthese disordersis important,as many TMAs are life-threatening,the treatmentsare distinct and selectingappropriatetherapy can improve patient prognosis.

Hematopoiesis Anemia

anaemia of folate deficiency drug-induced immune haemolytic anaemia haemolytic anaemia haemolytic anaemia due to g6pd deficiency idiopathic aplastic anaemia idiopathic autoimmune haemolytic anaemia immune haemolytic anaemia iron deficiency anaemia megaloblastic anaemia pernicious anaemia secondary aplastic anaemia sickle cell anaemia Mechanisms

Anemia: Pathophysiology & Diagnostic Classification

Sep 12, 2007 B. Hemolytic-uremic syndrome C. Sickle cell hemolytic crisis D. Immune hemolytic anemia. 1.) Increase in blood flow (or Q) 2.) Increase in red cell mass (or Hb


Autoimmune haemolytic anaemia This result from RBC destruction due to RBC autoantibodies, causing intravascular haemolysis, but if the complement is weak, the haemolysis will be extravascular. Antibody coated red cells will lose membrane to macrophages in the spleen and hence Spherocytes are present in the peripheral blood.

CHAPTER Pancytopenia: Clinical approach 95

megaloblastic anaemia seen in 72% cases, followed by aplastic anaemia (14%). The other causes included subleukaemic leukaemia (10 cases), myelodysplastic syndrome (4 cases), hypersplenism due to kala azar (4 cases), hypersplenism due to malaria (2 cases), Non-Hodgkin s lymphoma, myelofibrosis, multiple myeloma

Test questions - INTERNAL MEDICINE 3 - 4. class, summer

92. Haemolytic anaemia can be caused by following infections except: 93. Paroxysmal nocturnal haemoglobinuria (PNH) is diagnosed by: 94. Diagnostis test for the autoimmune haemolytic anaemia with the thermal antibodies is: 95. Diagnostic test for the hereditary spherocytosis (HS) is: 96. Anaemia with acantocyte red blood cells is caused by: 97.