Scleromyxedema With Systemic Involvement Mimics Rheumatic Diseases

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Scleromyxedema: Treatment with interferon alfa

ons will prove helpful in the systemic manifesta-tions of this rare disorder. REFERENCES 1. Harris AO, Altman AR, Tschen JA, Wolf JE. Sclero-myxedema. Int J Dermatol 1989;28:661-7. 2. Fudman EJ, Golbus J, Ike RW. Scleromyxedema with systemic involvement mimics rheumatic diseases. Arthri-tis Rheum 1986;29:913-7.

Systemic Sclerosis/Scleroderma: A Treatable Multisystem Disease

Oct 15, 2008 Systemic sclerosis (systemic scleroderma) is a chronic connective tissue disease of unknown etiology that causes wide- spread microvascular damage and excessive deposition of collagen in the skin

CREST Syndrome - a Limited Form of Systemic Scleroderma: a

Systemic scleroderma (SSc) is a multisystem disease with microvascular abnormalities, autoimmune disorders, excessive collagen production and deposition, and fi brosis of the skin and internal

Multiple Myeloma Masquerades as Rheumatic Diseases

Diagnosing rheumatic disease can be challenging because of protean manifestations and unexplained clinical features. We present two cases of multiple myeloma masquerading as rheumatic diseases, and describe how potential misdiagnoses were avoided. The first patient presented with thickened skin, mimicking systemic sclerosis.


SCLEROMYXEDEMA WITH SYSTEMIC INVOLVEMENT MIMICS RHEUMATIC DISEASES EDWARD J. FUDMAN, JOSEPH GOLBUS, and KOBERT W. IKE Scleromyxedema is an infiltrative skin disease produced by hyaluronic acid deposition in the dermis. A benign monoclonal gammopathy is usually present. We report 2 patients with scleromyxedema and systemic illnesses.

Erythema nodosum masking nephrogenic systemic fibrosis as

underlying systemic diseases or drug therapies. Our pa-tient has post-streptococcal like infection with EN changes demonstrated in the skin histology soon after she was be-ing exposed to gadolinium. In our part of the world, EN is commonly associated with streptococcal infection. How-ever, the findings of EN in the initial skin biopsy could also

Nοσήαα ης Εσωεριής Παθο ογίας πο ιού αι ρεαιά οσήαα

Joint involvement in 40 80% Pts frequently develop: Chronic multisystem dis RF and anti-CCP Abs (-)ve Non-erosive arthritis (large joints) Migratory polyarthritis The clinical presentation as inflammatory arthritis often leads to a misdiagnosis of: Arthralgia Spondyloarthritis Rheumatoid arthritis, or

Management of Systemic Sclerosis-Related Skin Disease

of several other inflammatory and immune-mediated diseases. The pattern of skin involvement, combined with salient features of the patient s past medical history and exposures, can help to discern the underlying cause of skin thickening Fig. 3. Raynaud s phenomenon (RP) in a patient with systemic sclerosis (SSc). Note the simul-