Mutational And Selective Processes Involved In Evolution During Bacterial Range Expansions

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Can the experimental evolution programme help us elucidate

by SF Bailey 2016 Cited by 52 formalized and detailed hypotheses regarding evolutionary processes and the genetic basis of adaptation for a wide range of Experimental evolution can be used to characterize mutations through time and independent selection of 2014) and now recent work in yeast and bacteria recent postglacial expansion.

Optimal bacteriophage mutation rates for phage therapy - Paul

Department of Ecology and Evolutionary Biology, Yale University, P.O. Box 208106, Increases to the mutation rate beyond the optimal value at mutation selection phage to control bacterial infections has recently sparked tially time-consuming process. resistance and subsequent phage host range expansion to.

Adaptive Evolution: How Bacteria and Cancer Cells Survive

5 May 2021 By dysregulating cellular processes associated with the transition from diversity​; selection and expansion of phenotypes capable of replicating under mutations during the stationary phase indicates that cells exposed to stress of transformation in a diverse range of solid tumors. Proc Natl Acad.

Stochastic processes drive rapid genomic divergence during

by C Weiss-Lehman 2019 Cited by 7 Evolution during range expansions occurs via several distinct, yet poten- data in bacteria [33,34]. In all of spatial selection was the key selective process acting on the contribution of both standing variation and de novo mutations We used fluorometric quantification (Qubit) and a NanoDrop spec-.

The Role of Clonal Interference in the Evolutionary Dynamics

by JM Hughes Cited by 32 While BHR plasmids replicate in a wide range of bacteria, they are not always the dynamics of bacterial evolution at the genotype level (16 19). In these ture suggests that a process called clonal interference may ex- plain at strong antibiotic selection on a large variety of mutations within the same 

Dissection of the mutation accumulation process during

by L Bosshard 2020 Cited by 4 process during bacterial range expansions deleterious mutations can accumulate due to inefficient selection on the expansion front, potentially interfering Results: We used whole genome sequencing to follow the genomic evolution of 10  11 pages

Range expansion with mutation and selection - IOPscience

by JT Kuhr 2011 Cited by 41 While the evolutionary dynamics leads to coalescence of both wild-type and selection process induces an increased surface roughness with exponents distinct from that study bacterial range expansion using a two-species Eden model, which selection on range expansion at rough, fluctuating fronts.

4 Natural Selection and Variation

and mutation, and we finish by looking at the argument to show that A life table can be used to describe the mortality of a population (Table 4.1). A life limit its further expansion. The evolution of drug resistance in HIV illustrates the process (we looked at this A sample of humans will show a range of sizes, distributed.

Genome expansion in early eukaryotes drove the - eLife

by M Colnaghi 2020 Cited by 2 reciprocal recombination during early eukaryotic evolution the origin of meiotic sex. these processes suggest that meiosis evolved from bacterial transformation Under this selection regime, mutations preferentially accumulate in the work, we included genome size as a variable as opposed to a 

Population size and the rate of evolution - kokkonuts

by R Lanfear 2014 Cited by 286 As Ne increases, natural selection becomes more effective at fixing advantageous mutations and removing deleterious mutations, but larger populations also 

Cancer in Light of Experimental Evolution - Cell Press

by K Sprouffske 2012 Cited by 91 how the understanding of mutation, selection, and spatial structure in seen a rapid expansion of experimental studies of evolution processes at a lower level of organisation: namely, the evolu- ulations of an experimental organism (e.g., bacteria or yeast) number of mutations involved in cancers and their epistatic.10 pages

Evolutionary mechanisms shaping the maintenance - CORE

by P Durão Cited by 99 Antibiotics target essential cellular functions but bacteria can become resistant by and epistasis and the effect of the environment on these processes. 21 resistance mutations can be selected at different antibiotic doses [17]), and the current and (2008) Adaptive plasmid evolution results in host-range expansion of a.

Rearrangements of the Bacterial Chromosome - Roth Lab

by JR ROTH Cited by 181 Rearrangements differ greatly from the point mutations that are more the selective forces that act to conserve the genetic map have secondarily shaped of bacteria, leading to evolution of a system that acts preferentially on information as long as the duplication is not entirely included within a single range of habitats.

Evolution and genomic signatures of - Genome Res

by N Riddiford 2021 Cited by 5 processes in the early stages of cancer evolution, we exploited Finally, we identified genomic features associated mutations acquired throughout life are harmless, some alter cellular normal cells and early-stage cancers represent the result of many years of selective bacterial and viral species.

Population Bottlenecks Strongly Influence the Evolutionary

by L Garoff 2020 Cited by 14 accumulation of deleterious versus high-fitness mutations when resistance requires multiple process involving the successive occurrence and selection of individ- In this process, a population of bacteria range of mutations that reduced susceptibility to CIP, even expansion later in the evolution (fig.

The Pleiotropic Effects of Beneficial Mutations of Adapted

by BS Van Dam 2014 When a single mutation effects fitness in multiple specialization, niche expansion, speciation, and even extinction in the face of consequences in a range of selective environments are numerous. Bacterial populations are ideal candidates for experimental evolution Excel's spreadsheet and charting processes.

Evolution at the Edge of Expanding Populations

by M Deforet 2019 Cited by 21 When does selection favor this survival of the fastest ? Keywords: range expansion, trade-off, dispersal, evolution, reaction- nies of the bacterium Pseudomonas aeruginosa leads to the We used DNA sequencing and genetic engineer- mutation in a gene called fleN, which gives them multiple fla-.

Genome-Wide Motif Statistics are Shaped by DNA Binding

by L Qian 2016 Cited by 8 binding proteins acting through tiny evolutionary steps over time protein, with typical values in the range of 4 10 base are largely devoid of local selective pressures that would exons of representative bacterial and eukaryotic genomes. mutational biases nor neutral processes involving repetitive.

Radial Domany-Kinzel Models with Mutation and Selection

by MO Lavrentovich 2013 Cited by 43 evolutionary dynamics in a simplified model of asexual organisms colonizing a new territory. Under occur in bacterial growth on a Petri dish, tumor growth, viral infections, human Two commonly used stochastic processes are the. Moran and tion size L in a linear range expansion at criticality, but.

Evolution by Small Steps and Rugged Landscapes in the RNA

by CL Burch 1999 Cited by 355 the mutated virus at a range of larger population sizes and allowed fitness to of deleterious mutations during one-plaque transfers (Chao by population expansion, which intensifies selection and re- ever, a single clone was used to avoid misidentifying steps generate epistasis with DNA bacteriophages, bacterial.

Evolutionary Limits and Constraints - Princeton University

by A Hoffmann Cited by 17 range expansion. 5. Limits and constraints: biodiversity and conservation. Although evolution is a powerful process that leads to Signatures of genetic constraints at sequence of mutations and a lack of selection to re- Constraints are also associated with de- bacteria can be maintained, and monitored adaptation.

Eco‐evolutionary dynamics of range expansion - ERA

by TOMEX MILLER 2020 Cited by 9 Like any evolutionary process, evolution during range genetic drift/ gene surfing (surfing of the neutral mutation is shown). expansion waves (Appendix S1), then spatial selection structure involved either replacement from a source pool of bacteria or yeast will eventually be dominated by one.

Mutability of demographic noise in microbial range expansions

by QQ Yu 2021 driving force in evolution because it reduces the efficacy of natural selection. but recent experiments with microbial range expansions have revealed deletions can increase the establishment probability of beneficial mutations by Fishers, IN, USA) were used at a similar surface density. consists of two steps (​Fig.

Allele Surfing Promotes Microbial Adaptation from - OSTI.GOV

by M Gralka 2016 Cited by 71 Eco-evolutionary feedback; Gene surfing; Range expansions; Biological can rapidly drive mutations to high frequency by chance alone (Edmonds et al. experimentally in various micro-organisms, including bacteria, single-celled fungi and experiments to measure the efficiency of selection during growth processes.

Evolutionary Pathways and Trajectories in Antibiotic Resistance

by RC San Millánb Cited by 2 Mutational Paths in Genes Involved in Antibiotic Resistance 110 Clonal mixtures, range expansion, spatial sorting, and evolution 179. 163 and drift) and directional (natural selection) processes; however, sequential pathways of. 231 Bacterial organisms have a high degree of variability, and the​. 272 

Peischl et al. - UBC Zoology

by S PEISCHL 2013 Cited by 233 We investigate the effect of spatial range expansions on the evolution of fitness when beneficial and Keywords: expansion load, fitness, gene surfing, mutation load, selective sweep. Received 31 single offspring, and the process is repeated N' times, leading to an associated with the ith mutation at any locus of the.

Mutator genomes decay, despite sustained fitness - PNAS

10 Oct 2017 fixation can drag along nonadaptive variation, a process dubbed. genetic draft reexamine current ideas about the evolution of bacterial ge- nomes, and they genes that encode the proteins involved in DNA replication, maintenance tions of selection and mutation in shaping mutator genomes over.

Nonadaptive processes in primate and human evolution

by EE Harris 2010 Cited by 25 selective constraint at the genetic level is expected to have effects at forces of evolutionary change, others being mutation, random filters used to identify orthologous genes across species. (e.g., in the bacteria species are usually greater than 40% and in Range expansions have occurred, sometimes recur- rently, in 

Life at the Front of an Expanding Population - JSTOR

by O Hallatschek 2010 Cited by 197 changes affect the dynamics of biological evolution in multiple ways. Recent sectors with an opening angle that depends sensitively on the selective advantage of the key words: Genetic drift, genetic load, neutral mutation, range expansion, stepping stone. microbial species, the bacterium E. coli (a mutant strain which.

Evidence of Selection upon Genomic GC-Content in Bacteria

by F Hildebrand 2010 Cited by 351 1 Centre for the Study of Evolution and School of Life Sciences, University of Sussex, Brighton, United Kingdom, mutations over ATRGC mutations segregating in all but the most AT-rich bacteria, across a broad range of phylogenetically strains for each gene and used parsimony to infer the ancestral.

Accumulation of deleterious mutations during bacterial range

by L Bosshard 2016 Cited by 53 Keywords: Range expansions, mutation load, experimental evolution the expansion process, leading to a drastic impairment of their We used E. coli K12 MG 1655 strains where the expression of the mutS gene is directly Selection, if any, should thus not be relaxed during this transfer, except for  40 pages

Mutational and Selective Processes Involved in Evolution

by L Bosshard 2019 Cited by 5 Bacterial populations have been shown to accumulate deleterious mutations during spatial expansions that overall decrease their fitness and ability to grow.15 pages

Allele surfing promotes microbial adaptation from standing

tions and can rapidly drive mutations to high frequency by ubiquitous process in populations that constantly turn over, including bacteria, single-celled fungi and social slime moulds, adaptation during range expansions and rationalise our quan- The selectable marker was used to tune the selective difference.

Viral host-adaptation : insights from evolution experiments

by JP Hall 2013 Cited by 20 To date a wide range of phages and their associated bacterial hosts. 37 process of phage evolution depending upon whether adaptation is against a accretion of mutations appears to be crucial to effective host-range expansion [12​,17]. bacterial host tends to accelerate phage evolution through continual selection for.

Cancer as an evolutionary and ecological process - Sites at

by LMF Merlo 2006 Cited by 1724 Cancer is a disease of clonal evolution within the body1 3. This has by natural selection and genetic drift, regardless of any nega- tive effects on ecological process. Lauren M.F. shown to inactivate genes associated with DNA-damage Estimations range from 3 12 mutations for different forms of 

Accumulation of Deleterious Mutations During Bacterial

by L Bosshard 2017 Cited by 53 rates of genetic drift on wave fronts making selection less efficient at purging deleterious variants. To test KEYWORDS range expansions; mutation load; experimental evolution. Beneficial effect of past demographic processes on the efficacy of selec- tion and on Bacterial strains: We used E. coli K12 MG 1655 strains.16 pages

Understanding bacterial adaptation to aerobic and anaerobic

by T Finn 2014 Cited by 2 Mutations that arose during evolution were identified by genome sequencing process whereby organisms that possess traits that allow them to better grow and pathways involved in adaptation to the aerobic and anaerobic environments. homology with bacterial viruses known as prophages, and may range in size 

Selective and non‐selective bottlenecks as drivers of the

by MDS Croix 2020 Cited by 2 derstanding of the nature of bottlenecks during bacterial infections A diverse range of hypermutable mechanisms High mutation rates allow for recovery of some additional genetic hint at a multifaceted evolutionary process with arguments for diverse representation in host-associated bacteria.

Evolutionary Trajectories to Antibiotic Resistance - Annual

by D Hughes 2017 Cited by 110 A graphic illustration of resistance evolution is mutational space, i.e., all types of mutations or to 10−5 per cell per generation when selection occurs at drug ments, bacterial pathogens are exposed to a wide range of various Epistasis describes situations where a phenotype associated with a gene 

Selection Threshold Severely Constrains Capture of

by JC Sanford 2013 Cited by 18 In a companion paper, careful numerical simulation was used to tions which are essentially un-selectable create a profound evolutionary paradox biological complexity of the mutation-selection process as it actually occurs in selection over the entire range of mutational effects considered in this 

Population and evolutionary dynamics during microbial range

by SR Gandhi 2019 replicating historical processes. system to gain a deeper understanding of spatial range expansions in a 3-1 Yeast expanding in a 1D metapopulation landscape is used to study eration of even deleterious mutations in the population [12]. the mechanisms behind non-darwinian selection in bacterial expansions.

A case study in evolutionary contingency - ScienceDirect.com

by ZD Blount 2016 Cited by 19 evolutionary outcomes path dependent to at least some degree (Wright 1988; Cooper and selection and biological and physical constraints greatly restrict the range of viable nutrients necessary for bacterial growth (Davis and Mingioli 1950). have involved multiple mutational steps taken prior to generation number 

Mutation load dynamics during environmentally-driven range

28 Sep 2018 range. The complexity of range expansions and range shifts scape. This is due to the increased efficacy of selection against deleterious variants at slow included in our analytic model. how evolutionary processes unfold within populations. deleterious mutations during bacterial range expansions.

Genetic drift, selection and the evolution of the mutation rate

by M Lynch 2016 Cited by 384 large range of variation implies that the rates, even at the single-gene level, have mutation remains associated with the mutator mutation-rate evolution is that natural selection primarily operates to improve stochastic nature of evolutionary processes, neutral fashion, even in the case of bacterial.

A multihost bacterial pathogen overcomes continuous

by R Bacigalupe 2019 Cited by 8 have led to the expansion of global epidemic clones (3 5). According- ovine host-switch event, involving the multihost pathogen S. aureus, providing the first To examine the adaptive evolution of S. aureus in the initial stages of of those mutations, within-host evolution may reflect dominance of a.

On the accumulation of deleterious mutations during range

by S Peischl 2013 Cited by 228 Evolution during range expansions is often viewed as a process in which species evolve where is is the selection coefficient associated to the i-th mutation at any locus of the focus mitigates the effects of deleterious mutations in bacteria.

Population size changes and selection drive - MPG.PuRe

by J Frickel 2018 Cited by 16 Here, we examine the degree of parallel evolution shaped through eco- tral mutations18 20, as well as genetic hitchhiking of non-adaptive expansions (​bue-shaded) in each replicate. b Algal population increased to populations were involved in cellular and signaling processes. host resistance range (Fig. 2​a) was 

Measurably evolving pathogens in the genomic era - Oliver

by R Biek 2015 Cited by 192 mutation rates, such as DNA viruses and bacteria, evolution is assessed at a genome-wide scale, and we highlight important sequence whole genomes for a diverse range of microbes. processes including immune selection, population expansion, spatial move- be used to infer transmission links, such as insertions.

5. EVOLUTION AS A POPULATION-GENETIC PROCESS

5 Apr 2020 example on a mutation with selective advantage or disadvantage s, with effects is substantially different among lineages, e.g., in bacteria vs. ln(2N) falls in the narrow range of 10 to 58 over a range of N = 104 to 1020, as below, for evolutionary changes involving interactions among loci, the scaling of.

In Vitro Selection of High-Level Beta-Lactam - MDPI

by V Gostev 2021 heterogeneity of the population; however, during the later stages, either bacteria in the European Union and European Economic Area [4] and is and included minor mutations with allele frequency in range 10 95% are Such an approach is used to study population fluctuations in long-term evolution.