Recent Advances In Blood Coagulation 5

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Tolerating Factor VIII: Recent Progress

a more recent study, non-neutralizing anti-FVIII antibodies were detected in ∼20% of plasma samples from >600 healthy non-HA blood donors (21, 30), although their predominant

Tissue factor: newer concepts in thrombosis and its role

Thus, recent advances in the biology of TF have clearly indicated that beyond its known effects on blood coagulation, it is a true surface receptor involved in many intracellular signaling, cell-survival, gene and protein expression,

Effects of low dose aspirin on platelet function in patients

1-1.5 g/day. Recent advances in understanding that aspirin inhib-its prostaglandin production in tissues other than plate-lets and further elucidation of its actions on platelet function have, however, raised doubts as to the speci-ficity for platelets of the drug as used in these clinical trials. For example, very low doses of aspirin suffice to

FORUM The effect of ionised magnesium on coagulation using

magnesium on coagulation has been assumed to be via prostacyclin, a potent inhibitor of platelet aggregation [4]. A recent in vivo study [5] into the effect of magnesium on haemostaticfactorsactually showed no change in thelevels of prostacyclin. In this study, although there was an increase in antithrombin III levels, the authors concluded

Unanswered questions in the use of blood component therapy in

ing of coagulation function with tailoring of treatment to the individual patient may improve our ability to administer blood component therapy in the acutely injured patient. Monitoring of coagulation function: Goal directed therapy A major limiting factor of current MT protocols is the lack of a real-time assessment of coagulation function.

Immune Factors in Deep Vein Thrombosis Initiation

In this review, we discuss recent advances in understanding the mechanisms of DVT, demonstrating a pivotal role of the immune system in its pathogenesis, is based on elevated blood coagulation

Current concepts of the coagulation system

Principles of Blood Coagulation Amplification Modified from Dahlbäck, Blood 2008 1, multiple linked enzymatic reactions 2, enzyme-cofactor complexes 3, surface localization 4, feed-back activation 5, coagulation factor concentrations increasing in pathway

DOI: 10.7860/JCDR/2017/22659.9463 Review Article Recent

Recent Advances in the Management of Major Postpartum Haemorrhage - A Review P Reddi Rani1, JaSMina BeGUM2 on the results of coagulation. Compatible blood is the best fluid

Coagulation and fibrinolysis in gastric cancer

Coagulation is a highly conserved process occurring after an injury to a blood vessel and resulting in hemostasis. Recent advances in deciphering the complex molecular link between GC and

Recent advances in clinical practice INFECTION, COAGULATION

Recent advances in clinical practice INFECTION, COAGULATION, AND VARICEAL BLEEDING IN CIRRHOSIS UThalheimer,CKTriantos,DNSamonakis,DPatch, A K Burroughs Gut 2005;54:556 563. doi: 10.1136/gut.2004.048181 See end of article for authors affiliations Correspondence to: Professor A K Burroughs, Liver Transplantation and

A clinical survey of bleeding, thrombosis, and blood product

of recent laboratory advances. The fields of hematology and hepatology inter-face extensively because of the central role of the liver in the synthesis of pro- and anti-coagulation factors and hepatic clearance of by-products of he-mostasis and coagulation. As a result, indices of coagulation are an essential part of prognostic

Advances in Clinical and Basic Science of Coagulation

Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis. Wolfgang Bergmeier, University of North Carolina Silvio Antoniak, University of North Carolina Edward M. Conway, UBC Centre for Blood Research Cécile V. Denis, INSERM U1176 Lindsey A. George, University of Pennsylvania

A cell-based model of coagulation and its implications

(3-5) Although the concept of coagulation cascade was a successful model and a significant advance in the understanding of coagulation, more recent clinical and experimental observations show that the cascade hypothesis does not fully reflect in vivo hemostasis.(6) In recent years, the deficiencies of this classic model have become evident.

Advances in Critical Care Medicine - Scientific OA Journals

Advances in Critical Care Medicine Research Article pen Access Modified Clinical Monitoring Assessment Criteria for Multi-Organ Failure during Bacteremia and Sepsis Progression in a Pig Model Anna Waterhouse1,2,3#‡, Daniel C. Leslie1,2,4,5#, Dana E. Bolgen1,6, Shanda Lightbown 1,2,5, Nikolaos Dimitrakakis , Mark J.

Sepsis: Epidemiology, Pathophysiology, Classification

coagulation by activating factor XII of the coagulation cascade or indirectly through changing the endothelium function. The continual pro-inflammatory state also activates immunosuppressive mechanisms, leading to oscillations between hyper-inflammatory and immunosuppressive states during the clinical course of the disease.

Journal of Chemical and Pharmaceutical Research

are taken, the needle is removed between the samples to avoid blood coagulation. After the procedure is complete, the patient is typically asked to lie flat for 5-10 minutes to provide pressure over the procedure site. After that, assuming no bleeding is observed, the patient can get up and go about their normal activities.

Recent Advances in the Structure and Function of the

thology, June 3-5, 1988 in Boston, Massachusetts. ologic processes including muscle contraction, blood coagulation, enzyme activity, neural excitability, hormone release, and membrane permeability, in addition to being an essential structural component of the skeleton. The precise control of calcium ion

Survival from DIC following amniotic fluid embolism

Disseminated intravascular coagulation. In: Poller L, ed. Recent advances in blood coagula- tion Number two. Edinburgh, London. Churchill Livingstone, 1977: 293-31 1. 4. COLMAN RW, ROBBOY SJ, MINNA JD. Disse- minated intravascular coagulation (DIC): an approach. American Journal of Medicine 1972; 52 5. DAMUS PS, SALZMAN EW. Disseminated intravas-

Targeting factor Xa and thrombin: impact on coagulation andÂ

Cross-talk between coagulation and inflammation is now well recognised, including in atherosclerosis (4). In addition to their role in coagulation, factor Xa and thrombin are known to partici-pate in other physiological and pathophysiological cellular activ-ities, predominantly via activation of proteinase-activated recep-tors (PARs) (5, 6).

Biopolymers for Biomedical and Pharmaceutical Applications

Applications: Recent Advances and Overview of plasticizer are used in dialysis for blood supply or extracorporeal the coagulation, which causes intense contact with PVC and increases

Recent advances in the management of hemorrhoids

review article, which discusses advances in the man-agement of hemorrhoids. This includes conservative treatment (life style modification, oral medications, and topical treatment), office procedures (rubber band liga-tion, injection sclerotherapy, infrared and radiofrequen-cy coagulation, bipolar diathermy and direct-current

Thrombosis and Circulation Open Access Cimmino et al., J

primary function being to prevent blood losses [1]. Platelets, on one side, and the coagulation cascade, on the other, are the main components of hemostasis. During the last decade, our knowledge on the pathophysiology of coagulation cascade and platelet activation has progressively increased [1], with one of the most important advances

Recent advances in biotechnology for heparin and heparan

factors,chemokines,adhesionproteins,etc.)[4,5],allowingthesetoact as signaling molecules, playing an important role in cell adhesion, migration, differentiation, signaling and angiogenesis [6,7]. Most im-portantly, HS has physiological and pharmacological impact in blood coagulation, embryonic development, inflammatory response, and

The haematology of hyperthyroidism: abnormalities

Recent advances in our understanding ofthyroid hormone action at the cellular level have been recently reviewed.1 In hormone-responsive tissues, nuclear receptors for tri-iodothyronine (T3) are present and are involved in the initiation of hormone action. The receptors have been identified as non-histone proteins of molecular weight about

Endothelial control of the cardiovascular system: recent advances

tioned at the interface between the blood and the vessel wall. As such, it performs multiple functions: It is involved in the regulation of coagulation, leuko-cyte adhesion in inflanunation, vessel tone, and vas-cular smooth muscle cell growth, and also acts as a barrier to transvascular flux of liquids and solutes.

Recent advances in understanding serotonin regulation of

intestinal peristalsis, blood coagulation and the mainten-ance of blood pressure [3 5]. The altered regulation of serotonin in humans has been implicated in a wide range of psychiatric conditions, including obsessive compulsive disorder, depression, anxiety, eating disorders, substance abuse and dependence [6,7]. It has also been implicated in

Apixaban, an oral, direct and highly selective factor Xa

Keywords: apixaban, blood coagulation, direct factor Xa inhibitor, hemostasis, oral anticoagulant, thrombosis. Introduction Thrombosis is a major cause of morbidity and mortality in the Western world and contributes to cardiovascular disorders. Despite recent advances in interventional and medical therapy

Recent advances in modulators of circadian rhythms: an update

blood pressure6, blood lipids, coagulation-fibrinolysis balance, heart rate7,8, body temperature9, locomotor activity10,11, Recent advances in modulators of circadian rhythms: an update and

Crossroads of coagulation and innate immunity: the case of

Keywords: blood coagulation, immunity, innate, mono-cytes, neutrophils, platelet activation, venous thrombosis. DVT is a prevalent condition Deep vein thrombosis (DVT) is a major cause of morbid-ity and mortality worldwide. The reported mean incidence in the general population is between 0.5 and 1.4 per 1000

Recent advances in disseminated intravascular coagulation

function, and blood coagulation systems, including prosta-cyclin, nitric oxide, tissue factor pathway inhibitor, heparin sulfate, thrombomodulin, and endothelial protein C recep-tor (EPCR) (Figure 1) [5]. In particular, thrombomodulin-mediated binding to thrombin efficiently converts protein C to activated protein C, which results in limited

REVIEW ARTICLE Recent Advances in the Management of

Recent Advances in the Management of Postpartum Hemorrhage Usha Bhau, Indu Koul Prediction of PPH (1): Risk Factors for PPH includes a prolonged third stage of labor, multiple pregnancy, and history of postpartum hemorrhage. However, PPH also occurs in women with no risk factors. At every delivery strategies for minimising the effect of postpartum


5. Drug dose manipulation in case of child and elder patients is not possible. 6. Immediate withdrawal Recent advances in the Pulsatile Drug Delivery System: Nowadays pulsatile drug delivery systems are gaining importance in various disease conditions specifically in diabetes where dose is required at different time intervals.

Brief Reviews: Some Recent Advances in the Study of Hemostasis

blood clots. This revie ow focusen some of thse newer information concerning the clotting process and its inhibition, the relationship between clot-ting and such defense mechanisms as generation of kinins and fibrinolysis, and the role of complement in blood coagulation It attempt ts.o presen at sample of present trends rathe ar compen than -

Advances in Topical Hemostatic Agent Therapies: A

patients with intact coagulation system. Appropriate method is determined by the type of bleeding, the specific etiology, the individual coagulation status, and the clinician s experience and preference. Future hemostatic agents can be engineered towards both primary and secondary hemostasis mechanisms for an enhanced hemostatic response

Recent advances in prophylaxis against deep vein thrombosis.

Recent advances in prophylaxis against deep vein thrombosis Deep vein thrombosis (DVT) is a condition which presents a diagnostic and therapeutic challenge to all clinicians directly involved in patient care. The spec- trum of acute disease ranges from asymptomatic thrombosis (typically affecting distal, calf veins) dis-

Recen adance in he reeach and managemen of epi‑aociated DIC

Recent advances in the research and management of sepsis-associated DIC 29 1 3 Comparison to malignancy‑associated coagulopathy CancerisalsocomplicatedbyDIC.Similartosepsis,

Wetting and spreading of human blood: Recent advances and

elapsed since blood deposition, volume and blood s clot-ting response. Indeed, when blood is outside the body, its properties change rapidly due to platelet activation 30 leading to the coagulation cascade response. The impor-tance of understanding this problem for forensic science and biomedical applications, appears to be crucial since it

2010, 325-332 325 Tissue Factor/Factor FVII Complex

ing the most recent advances in the field of inhibitors of the complex TF/VIIa potentially useful in cardiovascular disease. Keywords: Blood coagulation, cardiovascular disease, factor VIIa, tissue factor. INTRODUCTION Blood coagulation is a complex biological mechanism aimed to avoid bleeding in which a highly regulated and

Recent advances in basic science Coagulation and fibrosis in

coagulation cascade. Classically, thrombin genera-tion is triggered when disruption of vascular integrity allows activation of plasma coagulation factors through the exposure of extravascular tissue factor. Thrombin converts circulating fibri-nogen to fibrin monomer, which polymerises to form fibrin, the fibrous matrix of blood clots.4

Mutations with epigenetic effects in myeloproliferative

this meeting, the most recent advances in laboratory research and clinical practice, including those that were presented at the 2010 ASH meeting, were discussed among recognized autho-rities in the field. The current paper summarizes the proceed-ings of this meeting in BCR-ABL1-negative MPN. We provide a