Gastrointestinal Infections After Transplantation
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Spectrum of Imaging Findings After Intestinal, Liver
Fig. 4. 39-year-old woman after intestinal transplantation necessitated by Gard-ner s syndrome with intraabdominal desmoid tumor (A) and graft failure and subse-quent retransplantation utilizing multivisceral graft (B and C). A, Contrast-enhanced MDCT scan obtained 2 months after initial intestinal trans-
INFECTIONS FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION
infections after blood and marrow transplantation. Transpl Infectious Disease 13-20, 1999; with permission.) The number of + signs indicates the relative frequency of infection. bFor CMV, risk is greatest in seropositive patients, irrespective of donor serostatus.
Late Infectious Complications after Liver Transplantation in
strategies after liver transplantation. Transpl Int 22(11): 1031-1040. 8. Paya CV, Wiesner RH, Hermans PE, Larson-Keller JJ, Ilstrup DM, et al. (1993) Risk factors for cytomegalovirus and severe bacterial infections following liver transplantation: a prospective multivariate time-dependent analysis. J Hepatol 18(2): 185-195.
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Gastrointestinal Complications Following Hematopoietic Stem
testinal infections. Acute GVHD usually develops 3-5 weeks after transplantation and it is most commonly diagnosed in conjunction with or it is usually heralded by such skin manifestations as maculopapular rash and pruritis. Chronic GVHD can develop following acute GVHD and it can arise several months after allogenic transplantation (6, 7). It is
Seminar Graft-versus-host disease
gastrointestinal tract, liver, skin, and lungs. The number of patients with this complication continues to grow, and many return home from transplant centres after HCT requiring continued treatment with immunosuppressive drugs that increases their risks for serious infections and other complications. In this Seminar, we review our understanding
Survey of HCMV in allogenic and autologous stem cell
ported in a period of about 28 to 72days after transplantation. It involves several organs including the lungs and intestines . HCMV is associated with vari-ous complications such as pneumonia, gastrointestinal infections, central nervous system infections, and retin-itis as well as many other miscellaneous disorders such
Clinical Outcomes and Healthcare Resource Utilization for
neic hematopoietic cell transplantation (allo-HCT). In its acute form (aGVHD), GVHD involves the skin, liver, and gastrointestinal (GI) tract, with GI involvement most strongly associated with poor prognosis. This retrospective cohort study used US healthcare claims data for 2008 to 2015 to identify patients who developed GI aGVHD after
Donor-derived vancomycin-resistant enterococci transmission
VRE infections following solid organ transplantation display a mortality of 9 48%, reaching 56 80% in the rst year after surgery . A history of previous colonization has been shown to be strongly associated with the sub-sequent development of VRE infection. Colonization is common in solid transplantation patients, with up to 12%
Fecal microbiota transplantation for norovirus infection: a
After FMT, complete symptom resolution was observed. Stool tests for NoV infection were repeated after 5days and at four different time - points over 5months and they all tested negative. No adverse events of clinical interest were observed. Fecal samples collected before FMT and 8 and 30days after the procedure were examined. The
Gastrointestinal tuberculosis following renal transplantation
after transplantation, manifesting as pulmonary or disseminated TB. Gastrointestinal TB (GITB) is a rare and potentially lethal manifestation of PTTB and may show delayed onset in renal transplant recipients due to the use of lower doses of immunosuppressants. Further, non-specificity of symptoms and the common occurrence of GI disorders in
Surgical Site Infections After Liver Retransplantation
Surgical site infections (SSIs) after liver transplantation (LT) are associated with an increased risk of graft loss and death. The incidence of SSIs after LT and their risk factors have been determined for ﬁrst LT but not for second LT. The impor-tance of reporting the incidence of SSIs risk-stratiﬁed by ﬁrst LT versus second LT is not
45 Case Report Pneumatosis intestinalis after lung
cell transplantation (HSCT), and the development of PI in these settings is thought to be associated with infection and immunosuppression, especially with the use of corticosteroids. In general, PI is rare after lung transplantation (LT), and to date, several cases of PI developing after LT for various lung diseases have
Transplant associated infections, - the role of the
kidney transplantation may play a key role in the pathogenesis of transplant-associated infections. This review will discuss the structure and function of the gas-trointestinal microbiota, the changes that occur in the gastrointestinal microbiota fol-lowing kidney transplantation and the factors underpinning these changes, how
Fecal microbiota transplantation prevents Candida albicans
transplantation Introduction. Many microbes, including bacteria, fungi, viruses, and parasites, symbiotically colonize the gastrointestinal (GI) tract (1). These microbes dynamically interact with each other and their host to maintain homeostasis. Dysbiosis, a disruption in the homeostasis of the gut microbiota, is
Potential of Mesenchymal Stem Cell-Derived Secretome
and gastrointestinal infections were observed in patients with inﬂammatory bowel diseases (IBDs) who received immunosuppressive drugs just before MSC injection . Autologous transplantation of MSCs is di cult to attempt on patients with fulminant diseases because of a long cell preparatory period and cell transplantation timing.
Morbidity and mortality of serious gastrointestinal
Background: Gastrointestinal complications after lung transplatation are associated with an increased risk of morbidity and mortality. This study aims to describe severe gastrointestinal complications (SGC) after lung transplantation. Methods: We performed a prospective, observational study that included 136 lung transplant patients during a
VIRAL GASTROINTESTINAL INFECTIONS IN ALLOGENEIC HEMATOPOIETIC
Gastrointestinal symptoms, and elevated liver enzymes, are common after HSCT, often due to drug toxicity, graft-versus-host disease (GVHD) or infections. It is essential to distinguish between GVHD and infection, since both conditions may progress to lethal disease, but require opposite strategies for the immunosuppressive treatment. Several of the
Functional Restoration of Bacteriomes and Viromes by Fecal
microbiota transplantation (FMT) is considered an effective therapy.1 However, 2 deaths caused by antibiotic-resistant bacterial infections after FMT have been reported,2,3 sug-gesting that a modiﬁcation of FMT or alternative treatments are required to resolve safety concerns about FMT. Previous
Gastrointestinal Cytomegalovirus Infection after Renal
2. Helderman JH, Goral S. Gastrointestinal complications of transplant immunosuppression. J Am Soc Nephrol 2002;13:277-87. 3. Franzin G, Muolo A, Griminelli T. Cytomegalovirus inclusions in the gastroduodenal mucosa of patients after renal transplantation. Gut 1981;22:698-701. 4. Mayoral JL, Loeffler CM, Fasola CG, Kramer MA, Orrom WJ, Matas AJ
FECAL MICROBIOTA TRANSPLANTATION IN GASTROINTESTINAL AND
FECAL MICROBIOTA TRANSPLANTATION FOR THE TREATMENT OF DIGESTIVE AND EXTRADIGESTIVE DISEASES C. Difficile Infection Usually, CDI develops after massive antibiotic treatment regimens, often among fragile patients. In hospital settings it happens commonly after antibiotic treatment and subsequent impairment of physiologic gut microbiota
Human herpesvirus 6 infections after liver transplantation
HHV-6 infections as early as 10 d and as late as 5 years after liver transplantation have been reported. Since the vast majority of patients have developed HHV-6 infections during early life and harbor the latent virus, the vast majority of HHV-6 infections after transplantation are believed to be due to endogenous reactivation.
Bacterial Foodborne Infections after Hematopoietic Cell
30 days of transplantation) were excluded from analyses. A total of 12 of 4069 (.3%) patients developed a bacterial foodborne infection within 1 year after transplantation. Patients with infections had a median age at transplantation of 50.5 years (interquartile range [IQR], 35 to 57), and the majority were adults 18 years of age (9 of 12 [75%
Medical Complications After Renal Transplantation
transplantation. However, some are more likely to occur earlier after transplantation and these include PTLD and Kaposi sarcoma. The incidence of malignancy continues to increase throughout the late post-transplantation period and the cumulative incidence of non-skin malignancy may reach 33% 30 years after transplantation.
Evaluation of Candida Infection after Six Months of
Background: Liver transplantation (LT) is the standard treatment of end-stage liver diseases (ESLD). Inva-sive fungal infection is one of the important causes of morbidity and mortality after transplantation. Objective: To determine the incidence of late-onset (after 6 months of LT) Candida infection in recipients.
Experience with sandoglobulin in bone marrow transplantation
marrow transplantation. The preparative regimen is associated with considerable non-hematologic toxicity. The preparative regimen furthermore has extensive hematological toxicity resulting in a prolonged complete aplasia. Graft-versus- host disease (GVHD) in its acute and chronic form is a major threat, as are op- portunistic viral infections.
Gastrointestinal Complications After Kidney Transplantation
and€ infections,€ can€ predispose€ kidney€ transplantation€ patients€ to€ the€ development€ of gastrointestinal€(GI)€problems.€The€diagnosis€of€severe€GI€complications€can€be€delayed
Organ or Stem Cell Transplant and Your Mouth
before and after transplantation. The patient may experience fewer oral and dental problems after transplantation by reducing the number of oral bacteria and inhibiting their proliferation. Instruct patients to bring a current list of their medications, including over-the-counter drugs, to every appointment and note those
INTRODUCTION TO THE DUMONT-UCLA INTESTINAL TRANSPLANT PROGRAM
infections after transplantation. Successful transplantation leads to independence from TPN and reliance solely on enteral/oral nutrition to meet caloric needs. Consults are available for intestinal transplant evaluation as well as to assist with the medical and
Use of recombinant factor VIIa in uncontrolled
hematopoietic stem cell transplantation (HSCT). Gastrointestinal (GI) bleeding, which is observed in 5% - 15% of patients after HSCT,1 is one of the most severe bleeding and associated with a graft-versus-host disease (GVHD), infections, the anticoagulation therapy, and conditioning regimen contribute to the development of GI bleeding.2,3 In
Severe gastrointestinal complications after 1,515 adult
Nov 14, 2019 Severe gastrointestinal complications after 1,515 adult kidney transplantations Abstract We studied, retrospec- tively, the occurrence of severe gas- trointestinal (GI) complications after kidney transplantation. After 1,5 15 consecutive adult kidney transplantations performed on 1,445 patients during 1990-1999 at our
Nutrition Interventions Before and After Adult Intestinal
other abdominal organ transplantation procedures and include significant cardiopulmonary insufficiency, advanced malignancy, severe immune deficiency syn-dromes, and life threatening intraabdominal or sys-temic infections (3). TYPE OF TRANSPLANTATION Intestinal transplantation includes three different types of surgical procedures.
Fecal Microbiota Transplantation (FMT)
Fecal Microbiota Transplantation (FMT) Background Fecal microbiota transplantation (FMT) is a procedure whereby donor fecal matter is placed into a patient s gastrointestinal system in order to recolonize it with normal gut bacteria that have been killed or suppressed. The most common use for FMT is treatment of Clostridium difficile infections.
Adenovirus Infections in Hematopoietic Stem Cell Transplant
time to engraftment, infections after transplantation, administra-tion of iv immune globulin and/or acyclovir, day from stem cell infusion to first culture positive for adenovirus, number and specific sites of infection with adenovirus, presence of symptoms suggestive of a clinical syndrome associated with adenovirus, biopsy or au-
CASE REPORT Open Access Volcano-like intermittent bleeding
retransplantation after simultaneous pancreas-kidney transplantation compared with pancreas after kidney transplantation. Transplant Proc 2007, 39:563-564. 4. Lopez NM, Jeon H, Ranjan D, Johnston TD: Atypical etiology of massive gastrointestinal bleeding: arterio-enteric fistula following enteric drained pancreas transplant. Am Surg 2004, 70
CT Features with Pathologic Correlation of Acute
gastrointestinal tract, and liver are the princi-pal targeted organs in patients with acute graft-versus-host disease. Symptoms of this disease are often nonspeciﬁc and include ab-dominal cramping, diarrhea, fever, nausea, and vomiting. The differential diagnosis in-cludes gastrointestinal infections, neutro-penic enterocolitis, and, during
Abdominal Complications Following Hematopoietic Stem Cell
combined with stem cell transplantation (3). Engraftment can be detected in the blood 2 4 weeks after infusion of hematopoietic stem cells. Although advances in immunosuppressive ther-apy and management of infections have improved long-term survival, transplant recipients remain at risk for a multitude of complications. These
4562 Original Article Clinical features of multidrug
Clinical features of MDRO infections in patients after organ transplantation procedures The clinical features including pathogens, infection sites, complications, and outcomes of MDRO infections in the early stage after different organ transplantation are shown in Table 2. Discussion Infections occurring early after SOT are usually surgery
Journal of Stem Cell Research & Therapy
Apr 30, 2013 The incidence of fungal infections is around 10%-20% after the transplantation . Fungal infections can cause a high mortality following HSCT, particularly allogenic grafts, because of receiving post transplantation immunosuppressive medications [22-24]. However, it varies in different transplantation centers depending on various factors
Cord Colitis Syndrome in Cord-Blood Stem-Cell Transplantation
after transplantation was 131 days (range, 88 to 314). All patients had a response to a 10-to-14-day course of empirical therapy with metronidazole, alone or in combination