No Association Between A Promoter Dopamine D4 Receptor Gene Variant And Schizophrenia

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a meta-analysis of data associating DRD4 gene

Dopamine is an endogenous neurotransmitter that primarily functions by binding to dopamine receptors, which have five types. The D4 receptor has attracted attention in the field of schizophrenia research. In postmortem brain striatum of patients with schizophrenia, the density of D4 receptor was significantly higher than in brain tissues

Unravelling the interaction between the DRD2 and DRD4

including D2 and D4 receptor subtypes, are involved in dopamine neurotransmission and may modulate memory, behaviour and execu-tive functions.8 9 The DRD2 gene encodes for the dopamine D2 receptor, and several func-tional genetic variants within the DRD2 gene were previously associated with personality traits.7 10 11 The DRD2 promoter rs12364283 (−844 A>G) variant was associated with D2

Behavioral and Brain Functions BioMed Central

related genes. Particularly, the association between a 48 bp variable number tandem repeat (VNTR) polymor-phism in exon 3 of the dopamine D4 receptor (DRD4) gene and novelty seeking (NS) has been studied inten-sively ever since the first study conducted by Ebstein et al. [3]. However, a limited number of studies have investi-

Multivariate Analysis of Dopaminergic Gene Variants as

Objective:To study the potential association between allelic variants of dopamine D2 receptor (DRD2), ANKK1 (ankyrin repeat and kinase domain containing 1), dopamine D4 receptor (DRD4), catechol-O-methyl transferase (COMT) and dopamine transporter (SLC6A3) genes and heroin dependence in Hungarian patients.

The dopamine receptor DRD4 gene:are duplications distracting?

association between the primarily inattentive subtype of ADHD and a 5′120-bp tandem duplication polymorphism in the gene encoding the dopamine D4 receptor (DRD4). Originally reported by Seaman etal.7, this 120-bp region contains putative transcription factor binding sequences. DRD4is a member of the dopamine D2 receptor gene family.

Clinical Features of Obsessive-Compulsive Disorder

polymorphisms in the gene coding for D4 dopamine receptor and OCD but no significant role of D2 and D3 receptors has been found (Cruz et al., 1997; Millet et al., 2003). Catechol-O-methyltransferase (COMT) is known to be an enzymatic mode of terminating the actions of circulating catecholamines, including dopamine. It has been shown that a common functional allele of the gene

The role of gene x social environment interactions in

Bipolar disorder, schizophrenia and autism have an estimated heritability, or genetic contribution to the phenotypic variation, of 80->90 percent (Burmeister et al., 2008). Genes regulate the cells of the human body by being the blueprint for proteins. However, when a mutation occurs in a gene the corresponding

BMC Molecular Biology BioMed Central

dopamine D4 receptor (DRD4) gene was originally cloned by Van Tol et al. [2]. The 5' flanking region of the gene was characterized by Kamakura et al. [3] as a house-keeping gene-like promoter. The promoter lacks a TATA or CAAT box but several putative transcription factor bind-ing sites and CpG islands have been identified. 5'-RACE


populations: schizophrenia, ADHD and Autism Spectrum Disorders. While the findings in the populations studied do not always converge, they all point to the usefulness of neuroimaging techniques such as fMRI as potential endophenotypes for parsing the genetic aetiology of executive function. 2

Der Einfluss von DRD4-Polymorphismen auf die Ausprägung

28. Kaiser R, Konneker M et al.: Dopamine D4 receptor 48-bp repeat polymorphism: no association with response to antipsychotic treatment, but association with catatonic schizophrenia, Mol Psychiatry 2000: 5(4): 418-24. 29. Goff DC, Coyle JT: The emerging role of glutamate in the pathophysiology

A genome-wide association study of Cloninger's temperament

Several studies have found association between a variant of the dopamine D4 receptor gene and Novelty Seeking (Benjamin et al., 1996; Ebstein et al., 1997b; Ebstein et al., 1996), and between a polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene

Ladislav HOSÁK a, Jiř OSÁKOVÁ b

Rogers et al. (2004) investigated whether there is an association between a polymorphic 120 base pairs repeat in the 5 -untranslated region of the dopamine D4 receptor gene and NS. The authors genotyped four separate groups from psychiatric clinical studies. There were significant associations with NS in the groups of bipolar (p<0.01) and

STUDI - Giù le Mani dai Bambini

22. Di Bella D., Catalano M., Cichon S., Nöthen M.M.: Association Study of a Null Mutation in the Dopamine D4 Receptor Gene in Italian Patients with Obsessive-Compulsive Disorder, Bipolar Mood Disorder and Schizophrenia Psychiatric Genetics 6: 119-122, 1996.

University Faculty Details Page on DU Web-site

MiRSNPs with schizophrenia and related traits Schizophrenia research 174(1-3):29-34(2016) 2. Punchaichira TJ, Prasad S, Deshpande SN, Thelma BK Deep sequencing identifies novel regulatory variants in the distal promoter region of the dopamine-β-hydroxylase gene. Pharmacogenet Genomics 26(7):311-23 (2016) 3.

Publikationsliste Alexander Strobel - TU Dresden

wanted variance in Implicit Association Tests of personality: Possible evidence for an affective valence confound. Frontiers in Psychology, 4, 672. 21. Anacker, K., Enge, S., Reif, A., Lesch, K.-P. & Strobel, A. (2013). Dopamine D4 receptor gene var-iation impacts self

Pharmacogenetics of methylphenidate response and

meta-analysis based on 16 studies reported no significant summary effect sizes.16 The involvement of the dopamine receptor D4 (DRD4) in treatment outcome has also been extensively examined, as it regulates dopamine synthesis, release and neuron-firing rate.17 One of the most frequently studied polymorphisms is the 48-bp VNTR in exon 3 of DRD4.


(STAR*D) study detected a significant association with a variant located in the serotonin 2A receptor gene (HTR2A).1 Pipamperone (PIP) is a weak antipsychotic used in the treatment of schizophrenia in a number of EU countries. At recommended doses (120 360 mg/d), PIP is only a moderate dopamine D2 receptor antagonist; at low

BMC Genetics BioMed Central

Background: The human dopamine D4 receptor (DRD4) is a candidate gene of great interest in molecular studies of human personality and psychiatric disorders. This gene is unique in having an exceptionally high amount of polymorphic sites both in the coding and in the promoter region.

Meta-Analysis of Case-Control and Family- © 2015 SAGE

transporter (5-HTT) gene, SLC6A4, has been reported to be involved in the pathogenesis of major psychiatric disorders, including anxiety, depression, schizophrenia, and autism (Graeff, 1997). A 44-bp insertion or deletion in the 5′-flank-ing promoter region of the 5-HTT gene (the 5-HTT-linked polymorphic region, 5-HTTLPR) creates a long (L) and a

BMC Psychiatry BioMed Central

effects, the dopamine D 4 receptor seems to modulate dopamine synthesis and turnover [17,18]. The dopamine D 4 receptor gene (DRD4) is located to chromosome 11p15.5 [19]. Recently, a putative functional DRD4 upstream region variant (-521C/T) was discovered, where the -521C allele was reported to be 40% less active than -