Induction Of Specific Escherichia Coli Genes By Sublethal Treatments With Alkylating Agents

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Specific Saccharomyces GenesAre Expressed Response to DNA

six specific genes. Wehave previously identified one damageinducible (DIN) gene as a genefusion (din-lacZ fusion) whose expression increases in response to DNA-damagingtreatments.

Induction of Escherichia coli genesbysublethal treatments

sponse is thought to bedueto the induction ofspecific gene products that act to repair alkylation-induced lesions in DNA(1). Subsequent biochemical studies have confirmed that at least twogene products are inducedbysuch adaptive treat-ments (3-6). Both of these products act to repair specific lesions produced in DNAby alkylating agents. One of the

Induction of Specific Escherichia coli Genes by Sublethal

Induction of specific Escherichia coli genes by sublethal treatments with alkylating agents (adaptive response/aid mutation/operon fusion/alkylation damage/DNA repair) MICHAEL R. VOLKERT AND DINH C. NGUYEN Laboratory of Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709